1. Metabolic Enzyme/Protease
    Apoptosis
  2. Dipeptidyl Peptidase
    Ferroptosis
  3. Alogliptin

Alogliptin (Synonyms: SYR-322 free base)

Cat. No.: HY-A0023A
Handling Instructions

Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Alogliptin Chemical Structure

Alogliptin Chemical Structure

CAS No. : 850649-61-5

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Top Publications Citing Use of Products

    Alogliptin purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2019 Apr 2;511(2):387-393.

    Western blotting analyses for TGF-b-induced phosphorylated Smad2/3 for Smad pathway, and phosphorylated Akt for non-Smad pathways and the effect of Alogliptin treatment.
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    Description

    Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes[1][2][3].

    IC50 & Target

    IC50: <10 nM (DPP-4)[1]

    In Vitro

    Alogliptin (1 nM; 5-60 min) inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells[2].
    Alogliptin (0.5-5 nM; 24 h) inhibits LPS-stimulated MMP-1 secretion and mRNA expression that is mediated by ERK pathway in U937 cells[2].

    In Vivo

    Alogliptin (0.01-1 mg/kg; p.o.) produced dose-dependent improvements in glucose tolerance and increased plasma insulin levels in female Wistar fatty rats[1].
    Alogliptin (40 mg/kg/day for 2 weeks; p.o.) reduces infarction area and improves brain vascular integrity in middle cerebral artery occlusion (MCAO) mice[3].

    Clinical Trial
    Molecular Weight

    339.39

    Formula

    C₁₈H₂₁N₅O₂

    CAS No.

    850649-61-5

    SMILES

    O=C(C=C(N1C[[email protected]](N)CCC1)N(C2=O)CC3=C(C#N)C=CC=C3)N2C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    AlogliptinSYR-322SYR322SYR 322Dipeptidyl PeptidaseFerroptosisDPPDPP-4diabetesInhibitorinhibitorinhibit

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