TAB2 - TGF-beta activated kinase 1 (MAP3K7) binding protein 2 Gene

Also Known as CHTD2; TAB-2; MAP3K7IP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23118

About TAB2

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,217,926-149,411,607 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues.

Summary

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

TAB2 Products (4)

mRNA	Protein	Name
NM_001292034.3	NP_001278963.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a
NM_001292035.3	NP_001278964.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform b
NM_001369506.1	NP_001356435.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a
NM_015093.6	NP_055908.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	15327770	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	10882101	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11460167	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	22158122	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	18079694	GOA
involved in heart development	IMP IMP: Inferred from mutant phenotype	20493459	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	36681779	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	33184450	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15327770	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11460167	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19193853	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	10882101	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAB2 Protein Structure

CUE

zf-RanBP

0
200
400
600
693 a.a.

Protein Preferred Names	Protein Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	TAK1-binding protein 2

TAB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAB2	Q9NYJ8	KRT85	Homo sapiens	P78386	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	KRT85	Homo sapiens	P78386	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	TAB2	Q9NYJ8	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	CAMK2A	Homo sapiens	Q9UQM7	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	CAMK2A	Homo sapiens	Q9UQM7	Validated Y2H	32296183
Intra	TAB2	Q9NYJ8	CAMK2A	Homo sapiens	Q9UQM7	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZFP64	Homo sapiens	Q9NTW7-5	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	ZFP64	Homo sapiens	Q9NTW7-5	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZNF143	Homo sapiens	P52747	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZNF143	Homo sapiens	P52747	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	TPM3	Homo sapiens	P06753	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	TAB1	Homo sapiens	Q15750	Y2H	21988832
Intra	TAB2	Q9NYJ8	TAB1	Homo sapiens	Q15750	Anti Tag CoIP	21903422
Intra	TAB2	Q9NYJ8	MAP3K7	Homo sapiens	O43318	Anti Bait CoIP	22081109
Intra	TAB2	Q9NYJ8	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	21903422
Intra	TAB2	Q9NYJ8	MAP3K7	Homo sapiens	O43318-2	TAP	14743216
Intra	TAB2	Q9NYJ8	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	19675569
Intra	TAB2	Q9NYJ8	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	ZBTB16	Homo sapiens	Q05516	Y2H	21988832
Intra	TAB2	Q9NYJ8	ZBTB16	Homo sapiens	Q05516	Confocal	21988832
Intra	TAB2	Q9NYJ8	ZBTB16	Homo sapiens	Q05516	Anti Tag CoIP	21988832
Intra	TAB2	Q9NYJ8	FOSL1	Homo sapiens	P15407	Y2H Array	21988832
Intra	TAB2	Q9NYJ8	FOSL1	Homo sapiens	P15407	Y2H Prey Pooling	32296183
Intra	TAB2	Q9NYJ8	FOSL1	Homo sapiens	P15407	Y2H Array	32296183
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	22081109
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Pull Down	22081109
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Y2H	22081109
Intra	TAB2	Q9NYJ8	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	22081109

Cross: Cross-species interaction Intra: Intraspecies interaction

TAB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85382	TAB2 Antibody (YA5074)	WB, ICC/IF, IP, ELISA, IF-Tissue	Human

Related Diseases

Diseases	Alias
Congenital Heart Defects, Multiple Types, 2	CHTD2 Congenital Heart Defects, Nonsyndromic, 2 Congenital Heart Defects Non-Syndromic 2
Polyvalvular Heart Disease Syndrome	Phd Syndrome
Type 1 Diabetes Mellitus 5	Diabetes Mellitus, Insulin-Dependent, 5 Latent Autoimmune Diabetes In Adults IDDM5 Insulin-Dependent Diabetes Mellitus 5 T1D5 Lada Type 1.5 Diabetes Diabetes Mellitus, Insulin-Dependent, Type 5
Encephalopathy	Brain Diseases Encephalopathies Toxic Encephalopathy Toxic Brain Fever Toxic Brain Inflammation Toxic Brain Stem Inflammation Toxic Cerebral Fever Toxic Cerebrospinal Fever Toxic Cerebrospinal Inflammation Encephalopathy Nec Encephalopathy Nos Encephalopathy Disease Encephalopathy Syndrome
Pelvic Organ Prolapse	Rectal Prolapse Pelvic Organ Prolapse, Susceptibility To, 1 Pelvic Organ Prolapse, Susceptibility To Prolapse Of Vagina And Rectum Vaginal Prolapse Pelvic Organ Prolapse 1 Procidentia, Rectum Prolapse Of Rectal Mucosa Procidentia Of Rectum Rectal Mucosa Prolapse Rectum Prolapse Procidentia Rectum Rp - [Rectal Prolapse] Male Proctocele Male Rectocele Proctoptosis Female Genital Prolapse Female Prolapse Incompetence Of Pelvic Fundus Relaxation Of Perineum Deficiency Of Perineum
Atrial Septal Defect 2	ASD2 Atrial Heart Septal Defect 2 Atrial Septal Defect-2 Asd Ii Septal Defect, Atrial, Type 2
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Frontometaphyseal Dysplasia	Fmd Dysplasia, Frontometaphyseal
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Otopalatodigital Syndrome Spectrum Disorder	Opd Spectrum Disorder Opsd Fronto-Otopalatodigital Osteodysplasia
Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant	ECTD10A Hed Ectodermal Dysplasia 10a Ectodermal Dysplasia Hypohidrotic Autosomal Dominant Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Autosomal Dominant Ad-Hed Autosomal Dominant Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia 3 Ed3 Eda3 Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant Dysplasia, Ectodermal, Type 3
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14134	TAB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19165	Tab2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25654	Tab2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAB2	VGNC	VGNC:53809
Mus musculus	TAB2	MGD	MGI:1915902
Macaca mulatta	TAB2	VGNC	VGNC:83476
Canis familiaris	TAB2	VGNC	VGNC:53995
Felis catus	TAB2	VGNC	VGNC:102528
Rattus norvegicus	TAB2	RGD	RGD:1309527
Others	TAB2	NCBI