ZNF143 - zinc finger protein 143 Gene

Also Known as SBF; STAF; pHZ-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7702

About ZNF143

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,461,012-9,528,524 (from NCBI)

This gene has 18 transcripts (splice variants), 220 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF143 Products (3)

mRNA Protein Name
NM_001282656.2 NP_001269585.1 zinc finger protein 143 isoform 2
NM_001282657.2 NP_001269586.1 zinc finger protein 143 isoform 3
NM_003442.6 NP_003433.3 zinc finger protein 143 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10893243 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10893243 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17938208 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of snRNA transcription by RNA polymerase II EXP
EXP: Inferred from Experiment
9009278 GOA
involved in positive regulation of transcription by RNA polymerase II EXP
EXP: Inferred from Experiment
9009278 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10893243 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF143 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (253 - 280)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (284 - 310)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (313 - 340)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (346 - 369)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (373 - 399)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (417 - 440)

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  • 400
  • 500
  • 600
  • 638 a.a.
Protein Preferred Names Protein Names

zinc finger protein 143

  • SPH-binding factor

ZNF143 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF143 P52747 IQUB Homo sapiens Q8NA54
Validated Y2H
32296183
Intra
ZNF143 P52747 NUDT22 Homo sapiens Q9BRQ3
Validated Y2H
32296183
Intra
ZNF143 P52747 YJU2 Homo sapiens Q9BW85
Validated Y2H
32296183
Intra
ZNF143 P52747 ZNF512B Homo sapiens Q96KM6
Validated Y2H
32296183
Intra
ZNF143 P52747 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
ZNF143 P52747 ZNF438 Homo sapiens Q7Z4V0
Validated Y2H
32296183
Intra
ZNF143 P52747 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
Intra
ZNF143 P52747 TCAF1 Homo sapiens Q9Y4C2-2
Validated Y2H
32296183
Intra
ZNF143 P52747 SPANXN3 Homo sapiens Q5MJ09
Validated Y2H
32296183
Intra
ZNF143 P52747 LIN54 Homo sapiens Q6MZP7
Validated Y2H
32296183
Intra
ZNF143 P52747 IL16 Homo sapiens Q14005-2
Validated Y2H
32296183
Intra
ZNF143 P52747 TAB2 Homo sapiens Q9NYJ8
Validated Y2H
32296183
Intra
ZNF143 P52747 EXOSC1 Homo sapiens Q9Y3B2
Validated Y2H
32296183
Intra
ZNF143 P52747 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
ZNF143 P52747 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Intra
ZNF143 P52747 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
ZNF143 P52747 EAF1 Homo sapiens Q96JC9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Disorders Of Intracellular Cobalamin Metabolism
Spherocytosis, Type 5

  • Hereditary Spherocytosis Type 5

  • SPH5

  • Hs5

  • Spherocytosis, Hereditary, 5

  • Hereditary Spherocytosis 5

  • Spherocytosis 5

  • Spherocytosis, Hereditary, Type 5
Basilar Artery Insufficiency

  • Basilar Artery Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120264 YPC-22026 Inhibitor / Unkown
HY-RS16103 ZNF143 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZNF143 VGNC VGNC:81612
Rattus norvegicus ZNF143 RGD RGD:1305662
Mus musculus ZNF143 MGD MGI:1277969
Canis familiaris ZNF143 VGNC VGNC:48661
Felis catus ZNF143 VGNC VGNC:67268
Bos taurus ZNF143 VGNC VGNC:58348
Others ZNF143 NCBI