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55702

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By Targets:	Amyloid-β (1) Beta-secretase (1) Drug Derivative (1) Endogenous Metabolite (1) Enterovirus (1) iGluR (1) Interleukin Related (1) Leukotriene Receptor (1) MicroRNA (8) Molecular Glues (1) PROTACs (1) Sodium Channel (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (6) Neurological Disease (3)
Oligonucleotides:	miRNA mimics (2) miRNA antagomirs (2) miRNA agomirs (2) MicroRNAs (8) miRNA inhibitors (2)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9949

Reslizumab Sch 55700; CDP-835; JES1-39D10	Interleukin Related	Inflammation/Immunology
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with K_D values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .

HY-13769A

TPT-260 Dihydrochloride 2 Publications Verification NSC55712; TPU-260 Dihydrochloride	Drug Derivative Amyloid-β Beta-secretase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (K_d = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .

HY-107607

*FPL-55712* free base**	Leukotriene Receptor	Inflammation/Immunology
FPL-55712 free base is a leukotriene receptor antagonist. FPL-55712 free base is also an antagonist of slow reacting substance of anaphylaxis (*SRS-A). FPL-55712* free base inhibits leukotriene-induced bronchoconstriction .**

HY-174329

*MRT-5702D*	Molecular Glues	Neurological Disease Cancer
MRT-5702D is a G3BP2 molecular glue degrader. MRT-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. MRT-5702D can be used for research of G3BP2-related cancers and neurodegenerative diseases .

HY-107607A

FPL-55712	Endogenous Metabolite	Inflammation/Immunology
FPL-55712 is a cysteine leukotriene type 1 receptor antagonist with anti-inflammatory activity. FPL-55712 can effectively block the biological response caused by leukotrienes, reduce allergic reactions and airway inflammation. FPL-55712 shows potential in suppressing asthma and allergic rhinitis .

HY-123602

*CGP 55802A*	iGluR	Neurological Disease
CGP 55802A is a novel photoaffinity ligand for in situ labeling of NMDA receptors with high selectivity for the glutamate recognition site .

HY-123493

P552-02 mesylate 552-02	Sodium Channel	Inflammation/Immunology
P552-02 (552-02) mesylate is a sodium channel blocker that is potentially used for the treatment of cystic fibrosis, exhibiting biological activity that enhances mucociliary clearance in the lungs while minimizing the risk of hyperkalaemia.

HY-RI01784A

*hsa-miR-5702* antagomir**	MicroRNA	Cancer
hsa-miR-5702 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5702 antagomir hsa-miR-5702 antagomir

HY-R01784

*hsa-miR-5702* mimic**	MicroRNA	Cancer
hsa-miR-5702 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-5702 mimic hsa-miR-5702 mimic

HY-RI01723A

*hsa-miR-5572* antagomir**	MicroRNA	Cancer
hsa-miR-5572 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5572 antagomir hsa-miR-5572 antagomir

HY-R01723

*hsa-miR-5572* mimic**	MicroRNA	Cancer
hsa-miR-5572 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-5572 mimic hsa-miR-5572 mimic

HY-177500

RGH 5702	Others	Inflammation/Immunology
RGH 5702 is a new mucosal mast cell protector, antiulcer agent .

HY-182924

Jun15702	PROTACs Enterovirus	Infection
Jun15702 is a PROTAC degrader targeting the capsid protein VP1 of enterovirus D68. Jun15702 recruits the Cereblon (CRBN) E3 ligase and activates the ubiquitin-proteasome pathway. Jun15702 inhibits viral entry and exerts inhibitory effects during the early, middle and late stages of viral replication. Jun15702 exhibits antiviral activity against multiple wild-type enterovirus D68 strains, and also shows submicromolar antiviral activity against the Pleconaril (HY-19952)-resistant enterovirus D68 variant rMO-VP1 F159V. Jun15702 can be used in studies related to enterovirus D68 (EV-D68) infection .

HY-R01784A

*hsa-miR-5702* agomir**	MicroRNA	Cancer
hsa-miR-5702 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5702 agomir hsa-miR-5702 agomir

HY-R01723A

*hsa-miR-5572* agomir**	MicroRNA	Cancer
hsa-miR-5572 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5572 agomir hsa-miR-5572 agomir

HY-RI01784

*hsa-miR-5702* inhibitor**	MicroRNA	Cancer
hsa-miR-5702 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-5702 inhibitor hsa-miR-5702 inhibitor

HY-RI01723

*hsa-miR-5572* inhibitor**	MicroRNA	Cancer
hsa-miR-5572 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-5572 inhibitor hsa-miR-5572 inhibitor

Cat. No.	Product Name	Target	Research Area	Image

HY-P9949

Reslizumab Sch 55700; CDP-835; JES1-39D10	Interleukin Related	Inflammation/Immunology
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with K_D values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .

Host:	Mouse (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (1) ICC/IF (3) WB (3) ELISA (3)
Isotype:	IgG (1) IgG1,IgG/Kappa (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85810

	GSDMD (N-terminal) Antibody (YA5502) 2 Publications Verification	WB, ICC/IF, ELISA	Human, Mouse, Rat
	GSDMD (N-terminal) Antibody (YA5502) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GSDMD.

HY-P85878

	HDAC1 Antibody (YA5570) Histone deacetylase 1; HD1;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	HDAC1 Antibody (YA5570) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HDAC1.

HY-P85880

	Chromogranin A Antibody (YA5572) beta Granin antibody; betagranin; N-terminal fragment of chromogranin A; antibody; catestatin antibody; CgA antibody; CHG A antibody; Chga antibody; chromofungin antibody; Chromogranin A antibody; Chromogranin A parathyroid secretory protein 1 antibody; Chromogranin A precursor antibody; ChromograninA antibody; CMGA_HUMAN antibody; ER-37 antibody; Pancreastatin antibody; Parastatin antibody; Parathyroid secretory protein 1 antibody; Pituitary secretory protein I antibody; Secretory protein I antibody; SP I antibody; SP-I antibody; SP1 antibody; SPI antibody; vasostatin 2 antibody; Vasostatin antibody; Vasostatin I antibody; Vasostatin II antibody; vasostatin-2 antibody;	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Chromogranin A Antibody (YA5572) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Chromogranin A.

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Cat. No.	Product Name		Classification

HY-RI01784A

*hsa-miR-5702* antagomir**		MicroRNAs miRNA antagomirs
hsa-miR-5702 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01784

*hsa-miR-5702* mimic**		MicroRNAs miRNA mimics
hsa-miR-5702 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01723A

*hsa-miR-5572* antagomir**		MicroRNAs miRNA antagomirs
hsa-miR-5572 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01723

*hsa-miR-5572* mimic**		MicroRNAs miRNA mimics
hsa-miR-5572 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01784A

*hsa-miR-5702* agomir**		MicroRNAs miRNA agomirs
hsa-miR-5702 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01723A

*hsa-miR-5572* agomir**		MicroRNAs miRNA agomirs
hsa-miR-5572 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01784

*hsa-miR-5702* inhibitor**		MicroRNAs miRNA inhibitors
hsa-miR-5702 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01723

*hsa-miR-5572* inhibitor**		MicroRNAs miRNA inhibitors
hsa-miR-5572 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

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