LIN54 - lin-54 DREAM MuvB core complex component Gene

Also Known as TCX1; JC8.6; CXCDC1; MIP120

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 132660

About LIN54

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,924,603-83,012,941 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.1), esophagus (RPKM 4.0) and 25 other tissues.

Summary

LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]

LIN54 Products (5)

mRNA Protein Name
NM_001115007.3 NP_001108479.1 protein lin-54 homolog isoform b
NM_001115008.3 NP_001108480.1 protein lin-54 homolog isoform b
NM_001288996.2 NP_001275925.1 protein lin-54 homolog isoform c
NM_001288997.1 NP_001275926.1 protein lin-54 homolog isoform b
NM_194282.4 NP_919258.2 protein lin-54 homolog isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables minor groove of adenine-thymine-rich DNA binding IDA
IDA: Inferred from direct assay
27465258 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17531812 GOA
enables transcription regulatory region nucleic acid binding IDA
IDA: Inferred from direct assay
27465258 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within nucleosome organization IDA
IDA: Inferred from direct assay
27465258 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription repressor complex IDA
IDA: Inferred from direct assay
27465258 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN54 Protein Structure

TCR

TCR: Tesmin/TSO1-like CXC domain, cysteine-rich domain (522 - 560)

TCR

TCR: Tesmin/TSO1-like CXC domain, cysteine-rich domain (594 - 634)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

protein lin-54 homolog

  • CXC domain-containing protein 1

LIN54 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIN54 Q6MZP7 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
LIN54 Q6MZP7 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
LIN54 Q6MZP7 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
LIN54 Q6MZP7 MYBL2 Homo sapiens P10244
Anti Tag CoIP
19725879
Intra
LIN54 Q6MZP7 MYBL2 Homo sapiens P10244
Anti Bait CoIP
17531812
Intra
LIN54 Q6MZP7 SF3A2 Homo sapiens Q15428
Y2H Array
32296183
Intra
LIN54 Q6MZP7 SF3A2 Homo sapiens Q15428
Y2H Prey Pooling
32296183
Intra
LIN54 Q6MZP7 ZNF143 Homo sapiens P52747
Y2H Prey Pooling
32296183
Intra
LIN54 Q6MZP7 ZNF143 Homo sapiens P52747
Y2H Array
32296183
Intra
LIN54 Q6MZP7 SP3 Homo sapiens Q02447
Y2H Prey Pooling
32296183
Intra
LIN54 Q6MZP7 SP3 Homo sapiens Q02447
Y2H Array
32296183
Intra
LIN54 Q6MZP7 ZNF76 Homo sapiens P36508
Y2H Prey Pooling
32296183
Intra
LIN54 Q6MZP7 ZNF76 Homo sapiens P36508
Y2H Array
32296183
Intra
LIN54 Q6MZP7 RBL2 Homo sapiens Q08999
Anti Tag CoIP
19725879
Intra
LIN54 Q6MZP7 RBL2 Homo sapiens Q08999
Anti Bait CoIP
17531812
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondyloarthropathy 1

  • Ankylosing Spondylitis

  • Spondyloarthropathy, Susceptibility To, 1

  • SPDA1

  • Marie-Strumpell Spondylitis

  • Bechterew Syndrome

  • Spa

  • Spondylarthritis Ankylopoietica

  • Reiter Syndrome

  • Ankylosing Spondylitis, Susceptibility To

  • Bekhterev Syndrome

  • Bekhterev'S Disease

  • Marie-Strumpell Disease

  • Axial Spondylarthritis

  • Bechterew Disease

  • Marie-Struempell Disease

  • Spondylitis Ankylopoietica

  • Spondyloarthritis

  • Spondyloarthritis Ankylopoietica

  • Spas

  • Ankylosing Spondylarthritis

  • Psoriatic Arthritis

  • Reactive Arthritis

  • Rheumatoid Spondylitis

  • Spondylitis Ankylosans

  • Spondylitis Ankylosing

  • Spondylitis, Ankylosing

  • Spondylarthropathies

  • Arthritis, Psoriatic

  • Arthritis, Reactive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07675 LIN54 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LIN54 MGD MGI:2140902
Canis familiaris LIN54 VGNC VGNC:42685
Bos taurus LIN54 VGNC VGNC:30894
Rattus norvegicus LIN54 RGD RGD:1311361
Felis catus LIN54 VGNC VGNC:63232
Macaca mulatta LIN54 VGNC VGNC:74123
Others LIN54 NCBI