SP3 - Sp3 transcription factor Gene

Also Known as SPR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6670

About SP3

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:173,900,775-173,965,702 (from NCBI)

This gene has 11 transcripts (splice variants), 276 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 21.0), thyroid (RPKM 19.7) and 25 other tissues.

Summary

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

SP3 Products (3)

mRNA	Protein	Name
NM_001017371.5	NP_001017371.3	transcription factor Sp3 isoform 2
NM_001172712.1	NP_001166183.1	transcription factor Sp3 isoform 3
NM_003111.5	NP_003102.1	transcription factor Sp3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14979875	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17130167	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10391891	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20091743	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12771217	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14979875	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14979875	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12560508	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP3 Protein Structure

zf-H2C2_2

0
200
400
600
781 a.a.

Protein Preferred Names	Protein Names
transcription factor Sp3	GC-binding transcription factor Sp3

SP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SP3	Q02447	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
Intra	SP3	Q02447	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	SP3	Q02447	LIN54	Homo sapiens	Q6MZP7	Validated Y2H	32296183
Intra	SP3	Q02447	PHF21A	Homo sapiens	Q96BD5	Validated Y2H	32296183
Intra	SP3	Q02447	ESR1	Homo sapiens	P03372	Anti Bait CoIP	10816575

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Basidiobolomycosis	Infection By Basidiobolus Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161794A	SP3N hydrochloride	Degrader	99.84%	Unkown
HY-161795	SP3CHO		87.50%	Unkown
HY-161794	SP3N	Degrader	/	Unkown
HY-RS13606	SP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123732	CRT0083914		/	Unkown
HY-173132	AKR1Cs-IN-1		/	Unkown
HY-180813	RORγ-IN-3	Inhibitor	/	Unkown
HY-RS18594	Sp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25079	Sp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SP3	VGNC	VGNC:77846
Rattus norvegicus	SP3	RGD	RGD:1583765
Bos taurus	SP3	VGNC	VGNC:35154
Felis catus	SP3	VGNC	VGNC:65587
Canis familiaris	SP3	VGNC	VGNC:53107
Mus musculus	SP3	MGD	MGI:1277166
Others	SP3	NCBI