CIB3 - calcium and integrin binding family member 3 Gene

Also Known as KIP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117286

About CIB3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,161,368-16,173,525 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CIB3 Products (2)

mRNA	Protein	Name
NM_001300922.2	NP_001287851.1	calcium and integrin-binding family member 3 isoform 2
NM_054113.4	NP_473454.1	calcium and integrin-binding family member 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	22779914	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	22779914	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22779914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIB3 Protein Structure

EF-hand_7

0
100
187 a.a.

Protein Preferred Names	Protein Names
calcium and integrin-binding family member 3	DNA-dependent protein kinase catalytic subunit-interacting protein 3

CIB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CIB3	Q96Q77	ENOX2	Homo sapiens	Q16206-2	Validated Y2H	25416956
Intra	CIB3	Q96Q77	ENOX2	Homo sapiens	Q16206-2	Y2H Array	25416956
Intra	CIB3	Q96Q77	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	25416956
Intra	CIB3	Q96Q77	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	25416956
Intra	CIB3	Q96Q77	SP4	Homo sapiens	Q02446	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	SP4	Homo sapiens	Q02446	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	CIB3	Q96Q77	KLF17	Homo sapiens	Q5JT82	Validated Y2H	25416956
Intra	CIB3	Q96Q77	KLF17	Homo sapiens	Q5JT82	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	KLF17	Homo sapiens	Q5JT82	Y2H Array	32296183
Intra	CIB3	Q96Q77	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	CIB3	Q96Q77	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF146	Homo sapiens	Q15072	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF146	Homo sapiens	Q15072	Y2H Array	32296183
Intra	CIB3	Q96Q77	ARMC8	Homo sapiens	Q8IUR7-6	Y2H Array	32296183
Intra	CIB3	Q96Q77	ARMC8	Homo sapiens	Q8IUR7-6	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF578	Homo sapiens	Q96N58	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF578	Homo sapiens	Q96N58	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF180	Homo sapiens	Q9UJW8-4	Validated Y2H	32296183
Intra	CIB3	Q96Q77	ZNF180	Homo sapiens	Q9UJW8-4	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF180	Homo sapiens	Q9UJW8-4	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	RBAK	Homo sapiens	Q9NYW8	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	RBAK	Homo sapiens	Q9NYW8	Validated Y2H	32296183
Intra	CIB3	Q96Q77	RBAK	Homo sapiens	Q9NYW8	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF317	Homo sapiens	Q96PQ6	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF317	Homo sapiens	Q96PQ6	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF177	Homo sapiens	Q13360-2	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF177	Homo sapiens	Q13360-2	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	C17orf50	Homo sapiens	Q8WW18	Y2H Array	32296183
Intra	CIB3	Q96Q77	C17orf50	Homo sapiens	Q8WW18	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZFP57	Homo sapiens	Q9NU63-3	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZFP57	Homo sapiens	Q9NU63-3	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZFP57	Homo sapiens	Q9NU63-3	Validated Y2H	32296183
Intra	CIB3	Q96Q77	ZNF19	Homo sapiens	P17023	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF19	Homo sapiens	P17023	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	CIB3	Q96Q77	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CIB3	Q96Q77	NANOS3	Homo sapiens	P60323-2	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	NANOS3	Homo sapiens	P60323-2	Y2H Array	32296183
Intra	CIB3	Q96Q77	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	CIB3	Q96Q77	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	TACC3	Homo sapiens	Q9Y6A5	Y2H Prey Pooling	25416956
Intra	CIB3	Q96Q77	TACC3	Homo sapiens	Q9Y6A5	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	TACC3	Homo sapiens	Q9Y6A5	Y2H Array	32296183
Intra	CIB3	Q96Q77	TACC3	Homo sapiens	Q9Y6A5	Validated Y2H	25416956
Intra	CIB3	Q96Q77	TACC3	Homo sapiens	Q9Y6A5	Validated Y2H	32296183
Intra	CIB3	Q96Q77	ZNF552	Homo sapiens	Q9H707	Validated Y2H	32296183
Intra	CIB3	Q96Q77	ZNF552	Homo sapiens	Q9H707	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF552	Homo sapiens	Q9H707	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZFP1	Homo sapiens	Q6P2D0	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZFP1	Homo sapiens	Q6P2D0	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF664	Homo sapiens	Q8N3J9	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF664	Homo sapiens	Q8N3J9	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	SYPL1	Homo sapiens	Q16563	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	SYPL1	Homo sapiens	Q16563	Y2H Array	32296183
Intra	CIB3	Q96Q77	TRIM14	Homo sapiens	Q14142	Y2H Array	32296183
Intra	CIB3	Q96Q77	TRIM14	Homo sapiens	Q14142	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	SERTAD1	Homo sapiens	Q53GC0	Y2H Prey Pooling	25416956
Intra	CIB3	Q96Q77	SERTAD1	Homo sapiens	Q53GC0	Validated Y2H	25416956
Intra	CIB3	Q96Q77	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	CIB3	Q96Q77	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	CIB3	Q96Q77	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	CIB3	Q96Q77	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	CIB3	Q96Q77	SP3	Homo sapiens	Q02447	Y2H Array	32296183
Intra	CIB3	Q96Q77	SP3	Homo sapiens	Q02447	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	SLPI	Homo sapiens	P03973	Y2H Array	32296183
Intra	CIB3	Q96Q77	SLPI	Homo sapiens	P03973	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF688	Homo sapiens	P0C7X2	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF688	Homo sapiens	P0C7X2	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	TRAF5	Homo sapiens	O00463	Y2H Array	32296183
Intra	CIB3	Q96Q77	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF835	Homo sapiens	Q9Y2P0	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	CIB3	Q96Q77	ZNF835	Homo sapiens	Q9Y2P0	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	CIB3	Q96Q77	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	CIB3	Q96Q77	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	CIB3	Q96Q77	ZNF329	Homo sapiens	Q86UD4	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF329	Homo sapiens	Q86UD4	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	CIB3	Q96Q77	ZBTB43	Homo sapiens	O43298	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	25416956
Intra	CIB3	Q96Q77	NME4	Homo sapiens	O00746	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	NME4	Homo sapiens	O00746	Y2H Array	32296183
Intra	CIB3	Q96Q77	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	CIB3	Q96Q77	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	32296183
Intra	CIB3	Q96Q77	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	CIB3	Q96Q77	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	CIB3	Q96Q77	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	CIB3	Q96Q77	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	CIB3	Q96Q77	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
Intra	CIB3	Q96Q77	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	CIB3	Q96Q77	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	CIB3	Q96Q77	TRIM2	Homo sapiens	Q9C040	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	TRIM2	Homo sapiens	Q9C040	Validated Y2H	32296183
Intra	CIB3	Q96Q77	TRIM2	Homo sapiens	Q9C040	Y2H Array	32296183
Intra	CIB3	Q96Q77	TRIM2	Homo sapiens	Q9C040	Y2H Array	25416956
Intra	CIB3	Q96Q77	ZNF276	Homo sapiens	Q8N554	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF276	Homo sapiens	Q8N554	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZNF398	Homo sapiens	Q8TD17	Y2H Array	25416956
Intra	CIB3	Q96Q77	ZNF398	Homo sapiens	Q8TD17	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF398	Homo sapiens	Q8TD17	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZSCAN5A	Homo sapiens	Q9BUG6	Y2H Prey Pooling	32296183
Intra	CIB3	Q96Q77	ZSCAN5A	Homo sapiens	Q9BUG6	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZSCAN5A	Homo sapiens	Q9BUG6	Validated Y2H	32296183
Intra	CIB3	Q96Q77	ZNF597	Homo sapiens	Q96LX8	Y2H Array	32296183
Intra	CIB3	Q96Q77	ZNF597	Homo sapiens	Q96LX8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Usher Syndrome, Type Ij	Usher Syndrome Type 1j USH1J Usher Syndrome Type Ij Usher Syndrome 1j Usher'S Syndrome Type 1j
Colon Small Cell Carcinoma	Colonic Small Cell Carcinoma Colon Small Cell Neuroendocrine Carcinoma
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Usher Syndrome, Type I	USH1 Usher Syndrome Type 1 Us1 Usher Syndrome, Type 1b Usher Syndrome Type 1e Retinitis Pigmentosa And Congenital Deafness Usher Syndrome, Type Ie USH1E Usher Syndrome, Type 1e Usher Syndrome, Type 1a Usher Syndrome, Type Ib Usher Syndrome Type 1b Usher Syndrome Type Ie Usher Syndrome Type I Usher 1 Usher Syndrome, Type 1 Ush1a Usher Syndrome, Type I, French Variety Usher Syndrome, Type Ia Usher Syndrome 1b USH1B Usher'S Syndrome Type 1b Usher Syndrome Type Ib Ushib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147918	Anticancer agent 73	Inhibitor	99.92%	Unkown
HY-RS02708	CIB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CIB3	VGNC	VGNC:39268
Bos taurus	CIB3	VGNC	VGNC:27361
Felis catus	CIB3	VGNC	VGNC:69375
Mus musculus	CIB3	MGD	MGI:2685953
Macaca mulatta	CIB3	VGNC	VGNC:71339
Rattus norvegicus	CIB3	RGD	RGD:1590245
Others	CIB3	NCBI