SP4 - Sp4 transcription factor Gene

Also Known as HF1B; SPR-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6671

About SP4

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:21,428,083-21,514,822 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 3.6), thyroid (RPKM 3.0) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]

SP4 Products (3)

mRNA	Protein	Name
NM_001326542.2	NP_001313471.1	transcription factor Sp4 isoform 2
NM_001326543.2	NP_001313472.1	transcription factor Sp4 isoform 3
NM_003112.5	NP_003103.2	transcription factor Sp4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive effect regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7559627	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12560508	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP4 Protein Structure

zf-H2C2_2

0
200
400
600
784 a.a.

Protein Preferred Names	Protein Names
transcription factor Sp4

SP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SP4	Q02446	PRR20C	Homo sapiens	P86479	Y2H Prey Pooling	25416956
Intra	SP4	Q02446	PRR20C	Homo sapiens	P86479	Y2H Array	25416956
Intra	SP4	Q02446	a0a024r5s0_human	Homo sapiens	EBI-10188461	Validated Y2H	25416956
Intra	SP4	Q02446	CIB3	Homo sapiens	Q96Q77	Y2H Prey Pooling	25416956
Intra	SP4	Q02446	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
Intra	SP4	Q02446	a0a024r5s0_human	Homo sapiens	EBI-10188461	Y2H Prey Pooling	25416956
Intra	SP4	Q02446	CIB3	Homo sapiens	Q96Q77	Validated Y2H	25416956
Intra	SP4	Q02446	CIB3	Homo sapiens	Q96Q77	Y2H Array	25416956
Intra	SP4	Q02446	FOXP2	Homo sapiens	Q75MZ5	Validated Y2H	25416956
Intra	SP4	Q02446	FOXP2	Homo sapiens	Q75MZ5	Y2H Prey Pooling	25416956
Intra	SP4	Q02446	LOC730441	Homo sapiens	Q4G0S1	Validated Y2H	25416956
Intra	SP4	Q02446	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	SP4	Q02446	POU2F1	Homo sapiens	P14859-6	Y2H Array	32296183
Intra	SP4	Q02446	POU2F1	Homo sapiens	P14859-6	Y2H Prey Pooling	32296183
Intra	SP4	Q02446	NRF1	Homo sapiens	Q16656-4	Validated Y2H	32296183
Intra	SP4	Q02446	NFYC	Homo sapiens	Q13952-2	Y2H Array	32296183
Intra	SP4	Q02446	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
Intra	SP4	Q02446	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	SP4	Q02446	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	SP4	Q02446	SPANXN3	Homo sapiens	Q5MJ09	Validated Y2H	32296183
Intra	SP4	Q02446	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	SP4	Q02446	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	SP4	Q02446	NRF1	Homo sapiens	Q16656	Validated Y2H	25416956
Intra	SP4	Q02446	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	SP4	Q02446	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
Intra	SP4	Q02446	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	SP4	Q02446	POU2F1	Homo sapiens	P14859	Y2H Array	25416956
Intra	SP4	Q02446	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	SP4	Q02446	LMO3	Homo sapiens	Q8TAP4	Y2H Prey Pooling	25416956
Intra	SP4	Q02446	LMO3	Homo sapiens	Q8TAP4	Y2H Array	25416956
Intra	SP4	Q02446	COL8A1	Homo sapiens	P27658	Y2H Prey Pooling	25416956
Intra	SP4	Q02446	COL8A1	Homo sapiens	P27658	Y2H Array	25416956
Intra	SP4	Q02446	ADAM15	Homo sapiens	Q13444	Validated Y2H	25416956
Intra	SP4	Q02446	ADAM15	Homo sapiens	Q13444	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Spastic Paraplegia 5a, Autosomal Recessive	SPG5A Hereditary Spastic Paraplegia 5a Autosomal Recessive Spastic Paraplegia 5a Autosomal Recessive Spastic Paraplegia Type 5a Spastic Paraplegia 5a Spastic Paraplegia Type 5a Spastic Paraplegia Type 5a, Recessive Autosomal Recessive Spastic Paraplegia Spastic Paraplegia-5a Paraplegia, Spastic, Autosomal Recessive, Type 5a
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-179528	DIM-3,5-Cl2		99.18%	Unkown
HY-156277	SP4f	Activator	99.77%	Unkown
HY-156276	SP4e	Activator	99.72%	Unkown
HY-482945	(SP-4-1)-[[4,4′,4′′,4′′′-(21H,23H-Porphine-5,10,15,20-tetrayl-κN21,κN22,κN23,κN24)tetrakis[benzenesulfonato]](6-)]cobaltate(3-)		/	Unkown
HY-RS13607	SP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W075610	Nickelate(4-), [[4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[benzoato]](6-)-N21,N22,N23,N24]-, tetrahydrogen, (SP-4-1)-		/	Unkown
HY-W456409	(SP-4-1)-[5,10,15,20-Tetra-4-pyridinyl-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]nickel		/	Unkown
HY-W456534	Cuprate(4-), [[4,4′,4′′,4′′′-(21H,23H-porphine-5,10,15,20-tetrayl-κN21,κN22,κN23,κN24)tetrakis[benzoato]](6-)]-, (SP-4-1)-		/	Unkown
HY-W456551	Copper, [2,7,12,17-tetrakis(1,1-dimethylethyl)-21H,23H-porphyrazinato(2-)-κN21,κN22,κN23,κN24]-, (SP-4-1)-		/	Unkown
HY-W456552	(SP-4-1)-[5,10,15,20-Tetrakis(4-ethynylphenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]zinc		/	Unkown
HY-W456554	Zincate(4-), [[4,4′,4′′,4′′′-(21H,23H-porphine-5,10,15,20-tetrayl-κN21,κN22,κN23,κN24)tetrakis[benzenesulfonato]](6-)]-, hydrogen (1:4), (SP-4-1)-		/	Unkown
HY-W456556	(SP-4-1)-[5,10,15,20-Tetraphenyl-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]tin		/	Unkown
HY-W456557	(SP-4-1)-[[4,4′,4′′,4′′′-(21H,23H-Porphine-5,10,15,20-tetrayl-κN21,κN22,κN23,κN24)tetrakis[benzoato]](6-)]manganate(3-)		/	Unkown
HY-W456558	(SP-4-1)-[5,10,15,20-Tetrakis(4-methylphenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]manganese		/	Unkown
HY-W456560	(SP-4-1)-[5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]manganese		/	Unkown
HY-W543252	(SP-4-1)-[[4,4',4'',4'''-(21H,23H-Porphine-5,10,15,20-tetrayl-κN21,κN22,κN23,κN24)tetrakis[benzoato]](6-)]cobaltate(4-)		/	Unkown
HY-W543724	(SP-4-1)-[5,10,15,20-Tetrakis(4-bromophenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]cobalt		/	Unkown
HY-W855971	(SP-4-1)-[29H,31H-phthalocyanine-2,9,16,23-tetracarboxylato(6-)-N29,N30,N31,N32]Nickelate(4-)		/	Unkown
HY-W855972	(SP-4-1)-[29H,31H-Phthalocyanine-2,9,16,23-tetracarboxylato(6-)-κN29,κN30,κN31,κN32]cobaltate(4-)		/	Unkown
HY-W855973	(SP-4-1)-[5,10,15,20-Tetrakis(4-bromophenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]copper		/	Unkown
HY-W855974	(SP-4-1)-[5,10,15,20-Tetrakis(4-bromophenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]nickel		/	Unkown
HY-RS18331	Sp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24810	Sp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SP4	VGNC	VGNC:80723
Macaca mulatta	SP4	VGNC	VGNC:77847
Bos taurus	SP4	VGNC	VGNC:35155
Rattus norvegicus	SP4	RGD	RGD:3741
Mus musculus	SP4	MGD	MGI:107595
Canis familiaris	SP4	VGNC	VGNC:46687
Others	SP4	NCBI