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LMO3 - LIM domain only 3 Gene

Also Known as RBTN3; RHOM3; RBTNL2; Rhom-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55885

About LMO3

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:16,548,372-16,610,174 (from NCBI)

This gene has 34 transcripts (splice variants), 205 orthologues and 20 paralogues. Biased expression in brain (RPKM 41.7), lung (RPKM 13.9) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

LMO3 Products (7)

mRNA	Protein	Name
NM_001001395.2	NP_001001395.1	LIM domain only protein 3 isoform 1
NM_001243609.1	NP_001230538.1	LIM domain only protein 3 isoform 1
NM_001243610.1	NP_001230539.1	LIM domain only protein 3 isoform 1
NM_001243611.1	NP_001230540.1	LIM domain only protein 3 isoform 2
NM_001243612.1	NP_001230541.1	LIM domain only protein 3 isoform 3
NM_001243613.1	NP_001230542.1	LIM domain only protein 3 isoform 4
NM_018640.5	NP_061110.2	LIM domain only protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	23823477	GOA
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23823477	GOA
involved in positive regulation of glucocorticoid receptor signaling pathway	IDA IDA: Inferred from direct assay	23823477	GOA
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	23823477	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23823477	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMO3 Protein Structure

LIM

0
100
145 a.a.

Protein Preferred Names	Protein Names
LIM domain only protein 3	LIM domain only 3 (rhombotin-like 2)

LMO3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LMO3	Q8TAP4	NUTM1	Homo sapiens	Q86Y26	Validated Y2H	25416956
Intra	LMO3	Q8TAP4	NUTM1	Homo sapiens	Q86Y26	Y2H Array	25416956
Intra	LMO3	Q8TAP4	SP4	Homo sapiens	Q02446	Validated Y2H	25416956
Intra	LMO3	Q8TAP4	FOS	Homo sapiens	Q6FG41	Validated Y2H	25416956
Intra	LMO3	Q8TAP4	FBLIM1	Homo sapiens	Q8WUP2	Y2H Array	31515488
Intra	LMO3	Q8TAP4	FBLIM1	Homo sapiens	Q8WUP2	Y2H Prey Pooling	25416956
Intra	LMO3	Q8TAP4	FBLIM1	Homo sapiens	Q8WUP2	Validated Y2H	25416956
Intra	LMO3	Q8TAP4	FBLIM1	Homo sapiens	Q8WUP2	Y2H Array	25416956
Intra	LMO3	Q8TAP4	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	25416956
Intra	LMO3	Q8TAP4	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	25416956
Intra	LMO3	Q8TAP4	LDB1	Homo sapiens	Q86U70	Anti Tag CoIP	33961781
Intra	LMO3	Q8TAP4	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	LMO3	Q8TAP4	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	LMO3	Q8TAP4	FAM131C	Homo sapiens	Q96AQ9	Y2H Prey Pooling	25416956
Intra	LMO3	Q8TAP4	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	LMO3	Q8TAP4	BANP	Homo sapiens	Q8N9N5	Y2H Array	25416956
Intra	LMO3	Q8TAP4	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	LMO3	Q8TAP4	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	LMO3	Q8TAP4	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	LMO3	Q8TAP4	SAMD3	Homo sapiens	Q8N6K7	Validated Y2H	25416956
Intra	LMO3	Q8TAP4	SAMD3	Homo sapiens	Q8N6K7	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chief Cell Adenoma	Chief Cell Adenoma Of Parathyroid Gland

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07719	LMO3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LMO3	MGD	MGI:102810
Bos taurus	LMO3	VGNC	VGNC:30935
Macaca mulatta	LMO3	VGNC	VGNC:100072
Felis catus	LMO3	VGNC	VGNC:68071
Canis familiaris	LMO3	VGNC	VGNC:42723
Rattus norvegicus	LMO3	RGD	RGD:1561357
Others	LMO3	NCBI