NUTM1 - NUT midline carcinoma family member 1 Gene

Also Known as NUT; FAM22H; C15orf55

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 256646

About NUTM1

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:34,343,315-34,357,735 (from NCBI)

This gene has 4 transcripts (splice variants), 96 orthologues, 6 paralogues and is associated with 71 phenotypes. Restricted expression toward testis (RPKM 8.8).

Summary

Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NUTM1 Products (3)

mRNA	Protein	Name
NM_001284292.2	NP_001271221.2	NUT family member 1 isoform 1
NM_001284293.2	NP_001271222.2	NUT family member 1 isoform 2
NM_175741.3	NP_786883.2	NUT family member 1 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUTM1 Protein Structure

NUT

0
200
400
600
800
1000
1132 a.a.

Protein Preferred Names	Protein Names
NUT family member 1	NAP1L4/NUTM1D fusion

NUTM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUTM1	Q86Y26	TP53BP2	Homo sapiens	Q13625-3	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
Intra	NUTM1	Q86Y26	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	NUTM1	Q86Y26	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	P4HA3	Homo sapiens	Q7Z4N8	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	P4HA3	Homo sapiens	Q7Z4N8	Y2H Array	31515488
Intra	NUTM1	Q86Y26	ZNF277	Homo sapiens	Q8WWA6	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	ZNF277	Homo sapiens	Q8WWA6	Y2H Array	25416956
Intra	NUTM1	Q86Y26	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	MORN4	Homo sapiens	Q8NDC4	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	MORN4	Homo sapiens	Q8NDC4	Y2H Array	25416956
Intra	NUTM1	Q86Y26	q9h641_human	Homo sapiens	Q9H641	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	SAMD4A	Homo sapiens	Q9UPU9	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	PSME4	Homo sapiens	Q14997	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	PSME4	Homo sapiens	Q14997	Y2H Array	25416956
Intra	NUTM1	Q86Y26	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
Intra	NUTM1	Q86Y26	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	NEBL	Homo sapiens	O76041	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	NUTM1	Q86Y26	HSPBAP1	Homo sapiens	Q96EW2	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	HSPBAP1	Homo sapiens	Q96EW2	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	NUTM1	Q86Y26	KANSL1	Homo sapiens	Q7Z3B3	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	LMO3	Homo sapiens	Q8TAP4	Y2H Prey Pooling	25416956
Intra	NUTM1	Q86Y26	IFIT2	Homo sapiens	Q8IZ03	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	IFIT2	Homo sapiens	Q8IZ03	Y2H Array	25416956
Intra	NUTM1	Q86Y26	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	ZMYND10	Homo sapiens	O75800	Y2H Array	25416956
Intra	NUTM1	Q86Y26	ALOX5	Homo sapiens	P09917	Y2H Array	31515488
Intra	NUTM1	Q86Y26	ALOX5	Homo sapiens	P09917	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	ALOX5	Homo sapiens	P09917	Y2H Array	25416956
Intra	NUTM1	Q86Y26	LHX8	Homo sapiens	Q68G74	Validated Y2H	25416956
Intra	NUTM1	Q86Y26	LHX8	Homo sapiens	Q68G74	Y2H Array	25416956
Intra	NUTM1	Q86Y26	LMO1	Homo sapiens	P25800	Y2H Array	25416956
Intra	NUTM1	Q86Y26	RIC8A	Homo sapiens	Q9NPQ8-4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

NUTM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86997	Nutm1 Antibody (YA6690)	WB, IHC-P, ICC/IF, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Nut Midline Carcinoma	Nuclear Protein In Testis Midline Carcinoma Nmc
Nasal Cavity Cancer	Nasal Cavity Carcinoma Malignant Neoplasm Of Nasal Cavities Malignant Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Carcinoma Of Nasal Cavity Malignant Neoplasm Of Nasal Cavity Neoplasm Of Nasal Cavity
Sinonasal Undifferentiated Carcinoma	Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses Snuc
Paranasal Sinus Cancer	Paranasal Sinus Adenoid Cystic Carcinoma Paranasal Sinus Mucoepidermoid Carcinoma Paranasal Sinus Squamous Cell Carcinoma Paranasal Sinus Neoplasms Adenoid Cystic Carcinoma Of Accessory Sinus Adenoid Cystic Carcinoma Of Paranasal Sinus Epidermoid Carcinoma Of The Paranasal Sinus Mucoepidermoid Carcinoma Of Accessory Sinus Paranasal Sinus Adenocarcinoma Squamous Cell Carcinoma Of Paranasal Sinus Paranasal Sinus Neoplasm Adenocarcinoma Of Accessory Sinus
Eccrine Sweat Gland Cancer	Malignant Eccrine Skin Neoplasm Malignant Eccrine Tumor
Mediastinum Sarcoma	Sarcoma Of Mediastinum
Laryngeal Neuroendocrine Tumor	Laryngeal Neuroendocrine Tumour Neuroendocrine Tumor Of Larynx Neuroendocrine Tumour Of Larynx Neuroendocrine Neoplasm Of Larynx
Internal Auditory Canal Lipoma	Lipoma Of The Internal Auditory Canal Inner Ear Lipoma
Eccrine Acrospiroma	Acrospiroma Poroma Eccrine Hidradenoma Eccrine Hidradenoma Of Skin Hidradenoma Adenoma, Sweat Gland Benign Neoplasm Of Sweat Gland Eccrine Poroma
Eccrine Sweat Gland Neoplasm	Eccrine Skin Neoplasm Eccrine Tumor Eccrine Neoplasm Malignant Eccrine Neoplasm
Ethmoid Sinus Cancer	Malignant Neoplasm Of Ethmoidal Sinus Malignant Tumor Of Ethmoid Sinus Malignant Tumor Of Ethmoidal Sinus Neoplasm Of Ethmoidal Sinus
Schneiderian Carcinoma	Cylindrical Cell Carcinoma
Nasal Cavity Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Nasal Cavity Squamous Cell Carcinoma Of The Nasal Cavity
Basaloid Squamous Cell Carcinoma	Basaloid Carcinoma
Eccrine Porocarcinoma	Porocarcinoma Eccrine Porocarcinoma Of Skin Malignant Eccrine Poroma
Extragonadal Nonseminomatous Germ Cell Tumor	Primary Malignant Extragonadal Nonseminoma Malignant Extragonadal Non-Seminomatous Germ Cell Tumor
Lymphoepithelioma-Like Thymic Carcinoma	Lymphoepithelioma-Like Carcinoma Of The Thymus Thymic Lymphoepithelioma-Like Carcinoma
Mucocele Of Salivary Gland	Ranula Salivary Cyst Salivary Gland Mucocele Mucous Retention Cyst Of Salivary Gland Retention Cyst Of Salivary Gland Sialocele Cyst Of Salivary Gland Or Duct Extravasation Cyst Of Salivary Gland
Keratinizing Squamous Cell Carcinoma	Squamous Cell Carcinoma, Keratinizing Keratinizing Epidermoid Carcinoma
Lymphoepithelioma-Like Carcinoma	Lymphoepithelial Carcinoma Nasopharyngeal Type Undifferentiated Carcinoma
Malignant Olfactory Nerve Neoplasm	Malignant Olfactory Nerve Tumor Malignant Tumor Of Olfactory Nerve Primary Malignant Neoplasm Of Olfactory Nerve
Smarca4-Deficient Sarcoma Of Thorax	Smarca4-Dts Smarca4-Deficient Thoracic Sarcoma
Cranial Nerve Malignant Neoplasm	Cranial Nerve Neoplasms Malignant Neoplasm Of Cranial Nerve Malignant Tumor Of Cranial Nerve Malignant Tumor Of The Cranial Nerve
Thymus Adenocarcinoma	Adenocarcinoma Of The Thymus Thymic Adenocarcinoma
Bladder Sarcoma	Sarcoma Of Bladder Sarcoma Of The Urinary Bladder
Thymus Large Cell Carcinoma	Large Cell Carcinoma Of The Thymus Thymic Large Cell Neuroendocrine Carcinoma
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Mediastinal Cancer	Mediastinal Neoplasms Mediastinal Tumor Mediastinum Cancer Neoplasm Of Mediastinum Tumour Of Mediastinum Malignant Tumor Of Mediastinum
Cns Neuroblastoma With Foxr2 Activation	Central Nervous System Neuroblastoma With Foxr2 Activation Cns Nb-Foxr2 Cns Neuroblastoma, Foxr2-Activated
Myoepithelial Carcinoma	Malignant Myoepithelioma Myoepithelioma Carcinoma
Central Nervous System Neuroblastoma
Sweat Gland Benign Neoplasm	Neoplasm Of Sweat Gland Sweat Gland Tumor Tumor Of The Sweat Gland Sweat Gland Neoplasms Sweat Gland Neoplasm
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Endobronchial Lipoma
Central Nervous System Germ Cell Tumor	Central Nervous System Germ Cell Tumour Germ Cell Tumor Of The Cns Germ Cell Tumour Of The Cns
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Hidradenoma	Adenoma, Sweat Gland Hidradenoma Of Skin Sweat Gland Adenoma Syringoadenoma Eccrine Acrospiroma Benign Neoplasm Of Sweat Gland
Paranasal Sinus Disease	Paranasal Sinus Diseases Disorder Of Nasal Sinus
Sweat Gland Disease	Sweat Gland Diseases
Tonsil Cancer	Tonsillar Neoplasms Malignant Neoplasm Of Faucial Tonsil Malignant Neoplasm Of Palatine Tonsil Malignant Neoplasm Of Tonsil, Faucial Malignant Tonsillar Tumor Malignant Tumor Of Tonsil Tonsillar Carcinoma Malignant Neoplasm Tonsil
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09706	NUTM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUTM1	RGD	RGD:1564529
Mus musculus	NUTM1	MGD	MGI:2661384
Others	NUTM1	NCBI