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P4HA3 - prolyl 4-hydroxylase subunit alpha 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283208

About P4HA3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,250,146-74,311,640 (from NCBI)

This gene has 7 transcripts (splice variants), 232 orthologues and 3 paralogues. Biased expression in urinary bladder (RPKM 3.9), gall bladder (RPKM 3.2) and 13 other tissues.

Summary

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in Collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In Collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

P4HA3 Products (2)

mRNA	Protein	Name
NM_001288748.2	NP_001275677.1	prolyl 4-hydroxylase subunit alpha-3 isoform 2 precursor
NM_182904.5	NP_878907.1	prolyl 4-hydroxylase subunit alpha-3 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P4HA3 Protein Structure

P4Ha_N

2OG-FeII_Oxy

0
100
200
300
400
500
544 a.a.

Protein Preferred Names	Protein Names
prolyl 4-hydroxylase subunit alpha-3	4-PH alpha-3

P4HA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	P4HA3	Q7Z4N8	NUTM1	Homo sapiens	Q86Y26	Y2H Array	25416956
Intra	P4HA3	Q7Z4N8	NUTM1	Homo sapiens	Q86Y26	Validated Y2H	25416956
Intra	P4HA3	Q7Z4N8	MAGEA2B	Homo sapiens	Q96E03	Y2H Prey Pooling	25416956
Intra	P4HA3	Q7Z4N8	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	CLPP	Homo sapiens	Q16740	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	CLPP	Homo sapiens	Q16740	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	FIRRM	Homo sapiens	Q9NSG2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	FIRRM	Homo sapiens	Q9NSG2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	FIRRM	Homo sapiens	Q9NSG2	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	ZBTB7B	Homo sapiens	O15156-2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	ZBTB7B	Homo sapiens	O15156-2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	ATN1	Homo sapiens	Q86V38	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	ATN1	Homo sapiens	Q86V38	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	ATN1	Homo sapiens	Q86V38	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	MCCD1	Homo sapiens	P59942	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	MCCD1	Homo sapiens	P59942	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	ADRA2C	Homo sapiens	P18825	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	ADRA2C	Homo sapiens	P18825	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	GGA3	Homo sapiens	Q9NZ52-2	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	GGA3	Homo sapiens	Q9NZ52-2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	GGA3	Homo sapiens	Q9NZ52-2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	RBFOX1	Homo sapiens	Q9NWB1-5	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	ANAPC11	Homo sapiens	Q9NYG5-2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	ANAPC11	Homo sapiens	Q9NYG5-2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	ANAPC11	Homo sapiens	Q9NYG5-2	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	CERCAM	Homo sapiens	Q5T4B2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	CERCAM	Homo sapiens	Q5T4B2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	ACOT8	Homo sapiens	O14734	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	ACOT8	Homo sapiens	O14734	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	TOX2	Homo sapiens	Q96NM4-3	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	TOX2	Homo sapiens	Q96NM4-3	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	TOX2	Homo sapiens	Q96NM4-3	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	NICN1	Homo sapiens	Q9BSH3	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	NICN1	Homo sapiens	Q9BSH3	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	NICN1	Homo sapiens	Q9BSH3	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	LRP2BP	Homo sapiens	Q9P2M1	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	LRP2BP	Homo sapiens	Q9P2M1	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	LRP2BP	Homo sapiens	Q9P2M1	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	MSRA	Homo sapiens	Q9UJ68	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	MSRA	Homo sapiens	Q9UJ68	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	MSRA	Homo sapiens	Q9UJ68	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	VPS37C	Homo sapiens	A5D8V6	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	C1QTNF2	Homo sapiens	Q9BXJ5	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	FAM136A	Homo sapiens	Q96C01	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	FAM136A	Homo sapiens	Q96C01	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	FAM136A	Homo sapiens	Q96C01	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	DTNBP1	Homo sapiens	Q96EV8	Y2H Prey Pooling	25416956
Intra	P4HA3	Q7Z4N8	DTNBP1	Homo sapiens	Q96EV8	Y2H Array	25416956
Intra	P4HA3	Q7Z4N8	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	MAGEA2	Homo sapiens	P43356	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	MAGEA2	Homo sapiens	P43356	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	MAGEC2	Homo sapiens	Q9UBF1	Y2H Array	25416956
Intra	P4HA3	Q7Z4N8	MAGEC2	Homo sapiens	Q9UBF1	Y2H Prey Pooling	25416956
Intra	P4HA3	Q7Z4N8	PSMB4	Homo sapiens	P28070	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	CT55	Homo sapiens	Q8WUE5	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	CT55	Homo sapiens	Q8WUE5	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	CT55	Homo sapiens	Q8WUE5	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	B9D2	Homo sapiens	Q9BPU9	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	B9D2	Homo sapiens	Q9BPU9	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	B9D2	Homo sapiens	Q9BPU9	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	CKMT2	Homo sapiens	P17540	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	CKMT2	Homo sapiens	P17540	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	WDR62	Homo sapiens	O43379	Validated Y2H	25416956
Intra	P4HA3	Q7Z4N8	WDR62	Homo sapiens	O43379	Y2H Array	25416956
Intra	P4HA3	Q7Z4N8	STMN3	Homo sapiens	Q9NZ72	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	STMN3	Homo sapiens	Q9NZ72	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	STMN3	Homo sapiens	Q9NZ72	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	HGS	Homo sapiens	O14964	Validated Y2H	25416956
Intra	P4HA3	Q7Z4N8	HGS	Homo sapiens	O14964	Y2H Prey Pooling	25416956
Intra	P4HA3	Q7Z4N8	CTNNBIP1	Homo sapiens	Q9NSA3	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	CTNNBIP1	Homo sapiens	Q9NSA3	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	CTNNBIP1	Homo sapiens	Q9NSA3	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	ZC3H12A	Homo sapiens	Q5D1E8	Validated Y2H	25416956
Intra	P4HA3	Q7Z4N8	ZC3H12A	Homo sapiens	Q5D1E8	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	ZC3H12A	Homo sapiens	Q5D1E8	Y2H Array	25416956
Intra	P4HA3	Q7Z4N8	ZC3H12A	Homo sapiens	Q5D1E8	Y2H Array	32296183
Intra	P4HA3	Q7Z4N8	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	P4HA3	Q7Z4N8	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	P4HA3	Q7Z4N8	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	P4HA3	Q7Z4N8	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	P4HA3	Q7Z4N8	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	P4HA3	Q7Z4N8	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Osteogenesis Imperfecta, Type Viii	Osteogenesis Imperfecta Type 8 OI8 Osteogenesis Imperfecta Type Viii Oi Type Viii Oi, Type Viii Osteogenesis Imperfecta 8 Oi-Viii
Hypoascorbemia	Scurvy Ascorbic Acid Deficiency Vitamin C Deficiency Vitamin C, Inability To Synthesize Deficiency Of Vitamin C Scorbutus Vitamin C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121172	1,4-DPCA	Inhibitor	99.78%	Unkown
HY-RS09944	P4HA3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS18675	P4ha3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25161	P4ha3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	P4HA3	VGNC	VGNC:75705
Mus musculus	P4HA3	MGD	MGI:2444049
Bos taurus	P4HA3	VGNC	VGNC:32537
Canis familiaris	P4HA3	VGNC	VGNC:44224
Rattus norvegicus	P4HA3	RGD	RGD:735150
Felis catus	P4HA3	VGNC	VGNC:64016
Others	P4HA3	NCBI