CTNNBIP1 - catenin beta interacting protein 1 Gene

Also Known as ICAT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56998

About CTNNBIP1

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,848,276-9,910,269 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 77.0), esophagus (RPKM 25.4) and 24 other tissues.

Summary

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CTNNBIP1 Products (2)

mRNA Protein Name
NM_001012329.2 NP_001012329.1 beta-catenin-interacting protein 1
NM_020248.3 NP_064633.1 beta-catenin-interacting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables armadillo repeat domain binding IPI
IPI: Inferred from physical interaction
12408825 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12408825 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12408824 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
18977368 GOA
involved in negative regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
18977368 GOA
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
12408825 GOA
involved in positive regulation of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
19569129 GOA
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
18977368 GOA
involved in regulation of vascular permeability involved in acute inflammatory response IMP
IMP: Inferred from mutant phenotype
18287330 GOA
Cellular Component GO Annotation Evidence References Source
part of beta-catenin destruction complex IDA
IDA: Inferred from direct assay
16188939 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19569129 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18287330 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18287330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTNNBIP1 Protein Structure

ICAT

ICAT: Beta-catenin-interacting protein ICAT (1 - 81)

  • 0
  • 81 a.a.
Protein Preferred Names Protein Names

beta-catenin-interacting protein 1

  • beta-catenin-interacting protein ICAT

CTNNBIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTNNBIP1 Q9NSA3 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
CTNNBIP1 Q9NSA3 MSS51 Homo sapiens Q4VC12
Y2H Array
32296183
Intra
CTNNBIP1 Q9NSA3 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra
CTNNBIP1 Q9NSA3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
CTNNBIP1 Q9NSA3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
CTNNBIP1 Q9NSA3 SPATA24 Homo sapiens Q86W54-2
Y2H Prey Pooling
32296183
Intra
CTNNBIP1 Q9NSA3 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
CTNNBIP1 Q9NSA3 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
CTNNBIP1 Q9NSA3 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
CTNNBIP1 Q9NSA3 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
CTNNBIP1 Q9NSA3 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
CTNNBIP1 Q9NSA3 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Cross
CTNNBIP1 Q9NSA3 Ctnnb1 Mus musculus Q02248
ITC
16293619
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
28514442
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
X-Ray Diffraction
12408824
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Competition Binding
18287330
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
33961781
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
21885566
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
17353931
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Pull Down
21885566
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
21885566
Intra
CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Pull Down
18287330
Intra
CTNNBIP1 Q9NSA3 INCA1 Homo sapiens Q0VD86
Validated Y2H
25416956
Intra
CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Y2H Prey Pooling
32296183
Intra
CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Anti Tag CoIP
33961781
Intra
CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Y2H Array
32296183
Intra
CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Anti Bait CoIP
17353931
Intra
CTNNBIP1 Q9NSA3 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CTNNBIP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810746 ICAT Antibody (YA9989) WB, IHC-P Human

Related Diseases

Diseases Alias
Cheilitis
Anterior Segment Dysgenesis 5

  • Anterior Segment Dysgenesis 5, Multiple Subtypes

  • ASGD5

  • Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Osteogenesis Imperfecta, Type I

  • Osteogenesis Imperfecta Type I

  • OI1

  • Oi, Type I

  • Osteogenesis Imperfecta Tarda

  • Osteogenesis Imperfecta With Blue Sclerae

  • Osteogenesis Imperfecta Type 1

  • Adair-Dighton Syndrome

  • Mild Osteogenesis Imperfecta

  • Non-Deforming Osteogenesis Imperfecta

  • Oi Type 1

  • Van Der Hoeve Syndrome

  • Classic Non-Deforming Oi With Blue Sclerae

  • Osteogenesis Imperfecta 1

  • Oi-I

  • Osteopenic Non-Fracture Syndrome

  • Osteogenesis Imperfecta, Mild

  • Osteogenesis Imperfecta

  • Lobstein'S Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03309 CTNNBIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22063 Ctnnbip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28581 Ctnnbip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CTNNBIP1 VGNC VGNC:80177
Rattus norvegicus CTNNBIP1 RGD RGD:1562749
Bos taurus CTNNBIP1 VGNC VGNC:27803
Mus musculus CTNNBIP1 MGD MGI:1915756
Others CTNNBIP1 NCBI