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C1QTNF2 - C1q and TNF related 2 Gene

Also Known as CTRP2; zacrp2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114898

About C1QTNF2

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,347,754-160,370,626 (from NCBI)

This gene has 2 transcripts (splice variants), 188 orthologues and 23 paralogues. Broad expression in testis (RPKM 1.3), lung (RPKM 1.2) and 23 other tissues.

Summary

Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in regulation of lipid metabolic process. Predicted to act upstream of or within positive regulation of MAPK cascade; positive regulation of glucose import; and positive regulation of small molecule metabolic process. Predicted to be located in extracellular space. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF2 Products (2)

mRNA	Protein	Name
NM_001366504.1	NP_001353433.1	complement C1q tumor necrosis factor-related protein 2 isoform 2 precursor
NM_031908.6	NP_114114.3	complement C1q tumor necrosis factor-related protein 2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QTNF2 Protein Structure

Collagen

C1q

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
complement C1q tumor necrosis factor-related protein 2	C1q and tumor necrosis factor related protein 2

C1QTNF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	C1QTNF2	Q9BXJ5	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	C1QTNF2	Q9BXJ5	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	C1QTNF2	Q9BXJ5	TIMM8A	Homo sapiens	O60220	Y2H Array	32296183
Intra	C1QTNF2	Q9BXJ5	TIMM8A	Homo sapiens	O60220	Y2H Prey Pooling	32296183
Intra	C1QTNF2	Q9BXJ5	HPCA	Homo sapiens	P84074	Y2H Prey Pooling	32296183
Intra	C1QTNF2	Q9BXJ5	HPCA	Homo sapiens	P84074	Y2H Array	32296183
Intra	C1QTNF2	Q9BXJ5	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	C1QTNF2	Q9BXJ5	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	C1QTNF2	Q9BXJ5	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	C1QTNF2	Q9BXJ5	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	25416956
Intra	C1QTNF2	Q9BXJ5	KLHL12	Homo sapiens	Q53G59	Y2H Array	25416956
Intra	C1QTNF2	Q9BXJ5	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	C1QTNF2	Q9BXJ5	CHIC2	Homo sapiens	Q9UKJ5	Validated Y2H	32296183
Intra	C1QTNF2	Q9BXJ5	HPCAL1	Homo sapiens	P37235	Y2H Array	32296183
Intra	C1QTNF2	Q9BXJ5	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	32296183
Intra	C1QTNF2	Q9BXJ5	HPCAL1	Homo sapiens	P37235	Y2H Array	25416956
Intra	C1QTNF2	Q9BXJ5	NCALD	Homo sapiens	P61601	MAPPIT	25416956
Intra	C1QTNF2	Q9BXJ5	NCALD	Homo sapiens	P61601	MAPPIT	32296183
Intra	C1QTNF2	Q9BXJ5	NCALD	Homo sapiens	P61601	Y2H Prey Pooling	25416956
Intra	C1QTNF2	Q9BXJ5	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32296183
Intra	C1QTNF2	Q9BXJ5	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	C1QTNF2	Q9BXJ5	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	C1QTNF2	Q9BXJ5	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	C1QTNF2	Q9BXJ5	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 19	RP19 Retinitis Pigmentosa-19 Retinitis Pigmentosa, Type 19
Late-Onset Retinal Degeneration	LORD Retinal Degeneration, Late-Onset, Autosomal Dominant Autosomal Dominant Late-Onset Retinal Degeneration Pigmentary Retinopathy Retinal Degeneration, Late-Onset Retinitis Pigmentosa
Vertigo, Benign Recurrent	Benign Paroxysmal Positional Vertigo Bppv Vestibulopathy, Familial BRV Vertigo, Benign Paroxysmal Positional Benign Paroxysmal Positional Nystagmus Benign Recurrent Vertigo Familial Benign Recurrent Vertigo Familial Vestibulopathy Benign Paroxysmal Nystagmus Bppv - [Benign Positional Paroxysmal Vertigo]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01728	C1QTNF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	C1QTNF2	VGNC	VGNC:38583
Felis catus	C1QTNF2	VGNC	VGNC:102169
Rattus norvegicus	C1QTNF2	RGD	RGD:1561041
Macaca mulatta	C1QTNF2	VGNC	VGNC:70312
Mus musculus	C1QTNF2	MGD	MGI:1916433
Bos taurus	C1QTNF2	VGNC	VGNC:26624
Others	C1QTNF2	NCBI