CHIC2 - cysteine rich hydrophobic domain 2 Gene

Also Known as BTL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26511

About CHIC2

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:54,009,789-54,091,879 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 41 phenotypes. Ubiquitous expression in testis (RPKM 2.4), gall bladder (RPKM 1.4) and 25 other tissues.

Summary

This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]

CHIC2 Products (1)

mRNA	Protein	Name
NM_012110.4	NP_036242.1	cysteine-rich hydrophobic domain-containing protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHIC2 Protein Structure

Erf4

0
100
165 a.a.

Protein Preferred Names	Protein Names
cysteine-rich hydrophobic domain-containing protein 2	BRX-like translocated in leukemia

CHIC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHIC2	Q9UKJ5	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	FLJ13057	Homo sapiens	Q53SE7	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE3C	Homo sapiens	Q5T5A8	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE3C	Homo sapiens	Q5T5A8	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Array	30886144
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE5A	Homo sapiens	Q5TCM9	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE5A	Homo sapiens	Q5TCM9	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE1F	Homo sapiens	Q5T754	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE1F	Homo sapiens	Q5T754	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	NDUFB7	Homo sapiens	P17568	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	NDUFB7	Homo sapiens	P17568	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	CHIC2	Q9UKJ5	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	AXIN2	Homo sapiens	Q9Y2T1	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	AXIN2	Homo sapiens	Q9Y2T1	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	AXIN2	Homo sapiens	Q9Y2T1	Validated Y2H	32296183
Intra	CHIC2	Q9UKJ5	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	HOXA1	Homo sapiens	P49639	Y2H Pooling	16189514
Intra	CHIC2	Q9UKJ5	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	DNAL4	Homo sapiens	O96015	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	DNAL4	Homo sapiens	O96015	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	19060904
Intra	CHIC2	Q9UKJ5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	19060904
Intra	CHIC2	Q9UKJ5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	16189514
Intra	CHIC2	Q9UKJ5	CATSPER1	Homo sapiens	Q8NEC5	Y2H Pooling	16189514
Intra	CHIC2	Q9UKJ5	PLEKHF1	Homo sapiens	Q96S99	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	PLEKHF1	Homo sapiens	Q96S99	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	LCE3A	Homo sapiens	Q5TA76	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE3A	Homo sapiens	Q5TA76	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Disseminated Eosinophilic Collagen Disease
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement	Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement
Splenic Flexure Cancer	Ca Splenic Flexure - Colon Malignant Neoplasm Of Splenic Flexure Malignant Tumor Of Splenic Flexure Malignant Neoplasm Of Splenic Flexure Of Colon
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Endomyocardial Fibrosis	Becker'S Disease Obscure African Cardiomyopathy African Endomyocardial Fibrosis Endomyocardial Sclerosis EMF Becker Muscular Dystrophy
Extracutaneous Mastocytoma	Mastocytoma Mast Cell Neoplasm Benign Mastocytoma
Sm-Ahnmd	Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Haematological Non-Mast Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Hematological Non-Mast-Cell Lineage Disease
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02630	CHIC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHIC2	VGNC	VGNC:27293
Canis familiaris	CHIC2	VGNC	VGNC:39216
Felis catus	CHIC2	VGNC	VGNC:107319
Mus musculus	CHIC2	MGD	MGI:1921527
Rattus norvegicus	CHIC2	RGD	RGD:1309278
Others	CHIC2	NCBI