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CARD10 - caspase recruitment domain family member 10 Gene

Also Known as BIMP1; IMD89; CARMA3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29775

About CARD10

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,490,362-37,519,415 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in small intestine (RPKM 15.9), duodenum (RPKM 15.0) and 22 other tissues.

Summary

The Caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in Apoptosis signaling through highly specific protein-protein homophilic interactions. Like several Other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

CARD10 Products (1)

mRNA	Protein	Name
NM_014550.4	NP_055365.2	caspase recruitment domain-containing protein 10

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11259443	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of NF-kappaB-inducing kinase activity	IDA IDA: Inferred from direct assay	11259443	GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	24863965	GOA
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	24863965	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD10 Protein Structure

CARD

0
200
400
600
800
1032 a.a.

Protein Preferred Names	Protein Names
caspase recruitment domain-containing protein 10	Bcl10 binding protein and activator of NFKB

CARD10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CARD10	Q9BWT7	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	CARD10	Q9BWT7	ZNF223	Homo sapiens	Q9UK11	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	CARD10	Q9BWT7	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	CARD10	Q9BWT7	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	ZNF286A	Homo sapiens	Q9HBT8	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	METTL17	Homo sapiens	Q9H7H0-2	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	CARD10	Q9BWT7	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	CARD10	Q9BWT7	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	CARD10	Q9BWT7	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	ZNF180	Homo sapiens	Q9UJW8-4	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	MGC50722	Homo sapiens	Q8IVT4	Y2H Array	32296183
Intra	CARD10	Q9BWT7	ZNF552	Homo sapiens	Q9H707	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	CARD10	Q9BWT7	GSTP1	Homo sapiens	P09211	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CARD10	Q9BWT7	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	CARD10	Q9BWT7	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	CARD10	Q9BWT7	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	CARD10	Q9BWT7	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	CHIC2	Homo sapiens	Q9UKJ5	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	GFAP	Homo sapiens	P14136	Y2H Array	32296183
Intra	CARD10	Q9BWT7	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
Intra	CARD10	Q9BWT7	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	CARD10	Q9BWT7	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Intra	CARD10	Q9BWT7	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CARD10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811203	CARD10 Antibody	WB, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Immunodeficiency 89 And Autoimmunity	IMD89
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Immunodeficiency 11	Immunodeficiency 11a Severe Combined Immunodeficiency Due To Card11 Deficiency IMD11A Imd11 Card11 Immunodeficiency Scid Due To Card11 Deficiency Card11 Deficiency Immunodeficiency 11 A
Microcytic Anemia	Iron-Refractory Iron Deficiency Anemia
Pityriasis Rubra Pilaris	PRP Devergie'S Disease Prp - [Pityriasis Rubra Pilaris]
Arrhythmogenic Right Ventricular Dysplasia, Familial, 5	Arrhythmogenic Right Ventricular Dysplasia 5 ARVD5 Arrhythmogenic Right Ventricular Cardiomyopathy 5 Arvc5 Familial Arrhythmogenic Right Ventricular Dysplasia 5 Dysplasia, Ventricular, Right, Arrhythmogenic, Type 5
Amelogenesis Imperfecta, Type Ie	Aih1 Amelogenesis Imperfecta Type 1e AI1E Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1 Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth Enamel Hypoplasia, X-Linked Amelogenesis Imperfecta Type Ie Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1 Enamel Hypoplasia X-Linked Amelogenesis Imperfecta, X-Linked 1 Amelogenesis Imperfecta, Type 1e Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth X-Linked Amelogenesis Imperfecta 1 X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1 X-Linked Enamel Hypoplasia Amelogenesis Imperfecta X-Linked 1 Amelogenesis Imperfecta 1e Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth Xai X-Linked Amelogenesis Imperfecta Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01915	CARD10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CARD10	RGD	RGD:1304949
Mus musculus	CARD10	MGD	MGI:2146012
Canis familiaris	CARD10	VGNC	VGNC:38713
Felis catus	CARD10	VGNC	VGNC:60363
Macaca mulatta	CARD10	VGNC	VGNC:70570
Bos taurus	CARD10	VGNC	VGNC:26760
Others	CARD10	NCBI