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CBY2 - chibby family member 2 Gene

Also Known as NURIT; SPERT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 220082

About CBY2

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:45,702,320-45,714,559 (from NCBI)

This gene has 4 transcripts (splice variants), 174 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 11.6).

Summary

Enables identical protein binding activity. Predicted to be located in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

CBY2 Products (3)

mRNA	Protein	Name
NM_001286341.2	NP_001273270.1	protein chibby homolog 2 isoform 2
NM_001286342.2	NP_001273271.1	protein chibby homolog 2 isoform 3
NM_152719.3	NP_689932.1	protein chibby homolog 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27107012	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBY2 Protein Structure

Chibby

0
100
200
300
400
448 a.a.

Protein Preferred Names	Protein Names
protein chibby homolog 2	novel leucine zipper testicular protein

CBY2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CBY2	Q8NA61	b2r6j3_human	Homo sapiens	B2R6J3	Y2H Array	25416956
Intra	CBY2	Q8NA61	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	CBY2	Q8NA61	RTP5	Homo sapiens	Q14D33	Y2H Array	25416956
Intra	CBY2	Q8NA61	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
Intra	CBY2	Q8NA61	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	CBY2	Q8NA61	RUNX1T1	Homo sapiens	Q06455-4	Y2H Array	25416956
Intra	CBY2	Q8NA61	SH3RF2	Homo sapiens	Q08AM8	Y2H Array	25416956
Intra	CBY2	Q8NA61	SH3RF2	Homo sapiens	Q08AM8	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CCDC198	Homo sapiens	Q9NVL8	Validated Y2H	25416956
Intra	CBY2	Q8NA61	PLEKHN1	Homo sapiens	Q494U1	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	CCDC146	Homo sapiens	Q8IYE0-2	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	CBY2	Q8NA61	LATS1	Homo sapiens	Q6PJG3	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	LATS1	Homo sapiens	Q6PJG3	Y2H Array	25416956
Intra	CBY2	Q8NA61	PID1	Homo sapiens	Q7Z2X4	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	DZIP1L	Homo sapiens	Q8IYY4	Validated Y2H	25416956
Intra	CBY2	Q8NA61	DZIP1L	Homo sapiens	Q8IYY4	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ARHGEF40	Homo sapiens	Q8TER5-2	Validated Y2H	25416956
Intra	CBY2	Q8NA61	ARHGEF40	Homo sapiens	Q8TER5-2	Y2H Array	25416956
Intra	CBY2	Q8NA61	ARHGEF40	Homo sapiens	Q8TER5-2	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	KLC3	Homo sapiens	Q6P597	Y2H Array	25416956
Intra	CBY2	Q8NA61	KLC3	Homo sapiens	Q6P597	Validated Y2H	25416956
Intra	CBY2	Q8NA61	MOS	Homo sapiens	P00540	Validated Y2H	25416956
Intra	CBY2	Q8NA61	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	CBY2	Q8NA61	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	CBY2	Q8NA61	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	25416956
Intra	CBY2	Q8NA61	PPP1R18	Homo sapiens	Q6NYC8	Y2H Array	25416956
Intra	CBY2	Q8NA61	PPP1R18	Homo sapiens	Q6NYC8	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
Intra	CBY2	Q8NA61	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
Intra	CBY2	Q8NA61	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ACTN1	Homo sapiens	P12814	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ACTN1	Homo sapiens	P12814	Validated Y2H	25416956
Intra	CBY2	Q8NA61	RPL9	Homo sapiens	P32969	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	RPL9	Homo sapiens	P32969	Validated Y2H	25416956
Intra	CBY2	Q8NA61	TXLNA	Homo sapiens	P40222	Y2H Array	25416956
Intra	CBY2	Q8NA61	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CEP95	Homo sapiens	Q96GE4	Y2H Array	25416956
Intra	CBY2	Q8NA61	CEP95	Homo sapiens	Q96GE4	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	CEP95	Homo sapiens	Q96GE4	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CCNG1	Homo sapiens	P51959	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	CCNG1	Homo sapiens	P51959	Y2H Array	25416956
Intra	CBY2	Q8NA61	DUSP14	Homo sapiens	O95147	Y2H Array	25416956
Intra	CBY2	Q8NA61	DUSP14	Homo sapiens	O95147	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	CBY2	Q8NA61	CKS1B	Homo sapiens	P61024	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CKS1B	Homo sapiens	P61024	Y2H Array	25416956
Intra	CBY2	Q8NA61	MED28	Homo sapiens	Q9H204	Y2H Array	25416956
Intra	CBY2	Q8NA61	MED28	Homo sapiens	Q9H204	Validated Y2H	25416956
Intra	CBY2	Q8NA61	MED28	Homo sapiens	Q9H204	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	CTNNAL1	Homo sapiens	Q9UBT7	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CTNNAL1	Homo sapiens	Q9UBT7	Y2H Array	25416956
Intra	CBY2	Q8NA61	CTNNAL1	Homo sapiens	Q9UBT7	Anti Tag CoIP	33961781
Intra	CBY2	Q8NA61	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	CBY2	Q8NA61	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	25416956
Intra	CBY2	Q8NA61	ZNF655	Homo sapiens	Q8N720	Y2H Array	31515488
Intra	CBY2	Q8NA61	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ZNF655	Homo sapiens	Q8N720	Y2H Array	25416956
Intra	CBY2	Q8NA61	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956
Intra	CBY2	Q8NA61	C19orf44	Homo sapiens	Q9H6X5	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	C19orf44	Homo sapiens	Q9H6X5	Validated Y2H	25416956
Intra	CBY2	Q8NA61	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
Intra	CBY2	Q8NA61	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
Intra	CBY2	Q8NA61	PIN1	Homo sapiens	Q13526	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	FRS3	Homo sapiens	O43559	Y2H Array	25416956
Intra	CBY2	Q8NA61	LENG1	Homo sapiens	Q96BZ8	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	LENG1	Homo sapiens	Q96BZ8	Y2H Array	25416956
Intra	CBY2	Q8NA61	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ZC2HC1C	Homo sapiens	Q53FD0	Y2H Array	25416956
Intra	CBY2	Q8NA61	CNNM3	Homo sapiens	Q8NE01	Y2H Array	25416956
Intra	CBY2	Q8NA61	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CHIC2	Homo sapiens	Q9UKJ5	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	LMO3	Homo sapiens	Q8TAP4	Validated Y2H	25416956
Intra	CBY2	Q8NA61	ELOA	Homo sapiens	Q14241	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ARMC7	Homo sapiens	Q9H6L4	Y2H Array	25416956
Intra	CBY2	Q8NA61	CHCHD3	Homo sapiens	Q9NX63	Validated Y2H	25416956
Intra	CBY2	Q8NA61	CHCHD3	Homo sapiens	Q9NX63	Y2H Array	25416956
Intra	CBY2	Q8NA61	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	ENKD1	Homo sapiens	Q9H0I2	Y2H Array	25416956
Intra	CBY2	Q8NA61	CEP44	Homo sapiens	Q9C0F1	Y2H Array	25416956
Intra	CBY2	Q8NA61	MLH1	Homo sapiens	P40692	Validated Y2H	25416956
Intra	CBY2	Q8NA61	MLH1	Homo sapiens	P40692	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	MLH1	Homo sapiens	P40692	Y2H Array	29892012
Intra	CBY2	Q8NA61	MLH1	Homo sapiens	P40692	Y2H Array	31515488
Intra	CBY2	Q8NA61	TSGA10	Homo sapiens	Q9BZW7	Validated Y2H	25416956
Intra	CBY2	Q8NA61	TSGA10	Homo sapiens	Q9BZW7	Y2H Array	25416956
Intra	CBY2	Q8NA61	ZNF581	Homo sapiens	Q9P0T4	Y2H Array	25416956
Intra	CBY2	Q8NA61	METTL17	Homo sapiens	Q9H7H0	Y2H Array	29892012
Intra	CBY2	Q8NA61	METTL17	Homo sapiens	Q9H7H0	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
Intra	CBY2	Q8NA61	LMO1	Homo sapiens	P25800	Validated Y2H	25416956
Intra	CBY2	Q8NA61	LMO1	Homo sapiens	P25800	Y2H Array	25416956
Intra	CBY2	Q8NA61	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	CBY2	Q8NA61	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	CBY2	Q8NA61	TCEANC	Homo sapiens	Q8N8B7	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02017	CBY2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CBY2	MGD	MGI:1915176
Bos taurus	CBY2	VGNC	VGNC:35205
Canis familiaris	CBY2	VGNC	VGNC:46732
Macaca mulatta	CBY2	VGNC	VGNC:78029
Felis catus	CBY2	VGNC	VGNC:102173
Rattus norvegicus	CBY2	RGD	RGD:1561044
Others	CBY2	NCBI