MLH1 - mutL homolog 1 Gene
Also Known as FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; LYNCH2; MMRCS1
Species: Homo sapiens
About MLH1
This gene has 38 transcripts (splice variants), 204 orthologues, 3 paralogues and is associated with 130 phenotypes. Ubiquitous expression in testis (RPKM 17.8), thyroid (RPKM 13.3) and 25 other tissues.
Summary
The protein encoded by this gene can heterodimerize with mismatch repair Endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon Cancer (HNPCC). [provided by RefSeq, Aug 2017]
MLH1 Products (23)
| mRNA | Protein | Name |
|---|---|---|
| NM_000249.4 | NP_000240.1 | DNA mismatch repair protein Mlh1 isoform 1 |
| NM_001167617.3 | NP_001161089.1 | DNA mismatch repair protein Mlh1 isoform 2 |
| NM_001167618.3 | NP_001161090.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001167619.3 | NP_001161091.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001258271.2 | NP_001245200.1 | DNA mismatch repair protein Mlh1 isoform 4 |
| NM_001258273.2 | NP_001245202.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001258274.3 | NP_001245203.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001354615.2 | NP_001341544.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001354616.2 | NP_001341545.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001354617.2 | NP_001341546.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001354618.2 | NP_001341547.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001354619.2 | NP_001341548.1 | DNA mismatch repair protein Mlh1 isoform 3 |
| NM_001354620.2 | NP_001341549.1 | DNA mismatch repair protein Mlh1 isoform 2 |
| NM_001354621.2 | NP_001341550.1 | DNA mismatch repair protein Mlh1 isoform 5 |
| NM_001354622.2 | NP_001341551.1 | DNA mismatch repair protein Mlh1 isoform 5 |
| NM_001354623.2 | NP_001341552.1 | DNA mismatch repair protein Mlh1 isoform 5 |
| NM_001354624.2 | NP_001341553.1 | DNA mismatch repair protein Mlh1 isoform 6 |
| NM_001354625.2 | NP_001341554.1 | DNA mismatch repair protein Mlh1 isoform 6 |
| NM_001354626.2 | NP_001341555.1 | DNA mismatch repair protein Mlh1 isoform 6 |
| NM_001354627.2 | NP_001341556.1 | DNA mismatch repair protein Mlh1 isoform 6 |
| NM_001354628.2 | NP_001341557.1 | DNA mismatch repair protein Mlh1 isoform 7 |
| NM_001354629.2 | NP_001341558.1 | DNA mismatch repair protein Mlh1 isoform 8 |
| NM_001354630.2 | NP_001341559.1 | DNA mismatch repair protein Mlh1 isoform 9 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| contributes to MutSalpha complex binding |
IDA
IDA: Inferred from direct assay
|
16403449 | GOA |
| enables chromatin binding |
IDA
IDA: Inferred from direct assay
|
26300262 | GOA |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
26300262 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
2414623 | GOA |
| contributes to single-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
11809883 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within mismatch repair |
IGI
IGI: Inferred from genetic interaction
|
23603115 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
26300262 | GOA |
MLH1 Protein Structure
HATPase_c_3: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (28 - 130)
DNA_mis_repair: DNA mismatch repair protein, C-terminal domain (216 - 334)
- 0
- 200
- 400
- 600
- 756 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
DNA mismatch repair protein Mlh1 |
|
MLH1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MLH1 | P40692 | MAGEA8 | Homo sapiens | P43361 | 25910212 | |
|
Intra
|
MLH1 | P40692 | MAGEA8 | Homo sapiens | P43361 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MAGEA8 | Homo sapiens | P43361 | 25910212 | |
|
Intra
|
MLH1 | P40692 | MAGEA8 | Homo sapiens | P43361 | 25910212 | |
|
Intra
|
MLH1 | P40692 | MAGEA8 | Homo sapiens | P43361 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MAGEA8 | Homo sapiens | P43361 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PTPN3 | Homo sapiens | P26045 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PTPN3 | Homo sapiens | P26045 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PER2 | Homo sapiens | O15055 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PER2 | Homo sapiens | O15055 | 32296183 | |
|
Intra
|
MLH1 | P40692 | DES | Homo sapiens | P17661 | 20706999 | |
|
Intra
|
MLH1 | P40692 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
MLH1 | P40692 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
MLH1 | P40692 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZFP90 | Homo sapiens | Q8TF47 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZFP90 | Homo sapiens | Q8TF47 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZFP90 | Homo sapiens | Q8TF47 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61-2 | 25910212 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61-2 | 25910212 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61-2 | 27107012 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61-2 | 25910212 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | AP2B1 | Homo sapiens | P63010-2 | 25910212 | |
|
Intra
|
MLH1 | P40692 | AP2B1 | Homo sapiens | P63010-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | AP2B1 | Homo sapiens | P63010-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | AP2B1 | Homo sapiens | P63010-2 | 25910212 | |
|
Intra
|
MLH1 | P40692 | AP2B1 | Homo sapiens | P63010-2 | 27107012 | |
|
Intra
|
MLH1 | P40692 | AP2B1 | Homo sapiens | P63010-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | AP2B1 | Homo sapiens | P63010-2 | 25910212 | |
|
Intra
|
MLH1 | P40692 | PIP4K2B | Homo sapiens | P78356-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PIP4K2B | Homo sapiens | P78356-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PIP4K2B | Homo sapiens | P78356-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 11292842 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 16083711 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 11292842 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 17581638 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 25502805 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 25077178 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 11292842 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 33961781 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 34591612 | |
|
Intra
|
MLH1 | P40692 | PMS2 | Homo sapiens | P54278 | 22252508 | |
|
Intra
|
MLH1 | P40692 | MSH3 | Homo sapiens | P20585 | 25416956 | |
|
Intra
|
MLH1 | P40692 | MSH3 | Homo sapiens | P20585 | 25416956 | |
|
Intra
|
MLH1 | P40692 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TFAP2D | Homo sapiens | Q7Z6R9 | 32296183 | |
|
Intra
|
MLH1 | P40692 | AP1B1 | Homo sapiens | Q10567-3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | AP1B1 | Homo sapiens | Q10567-3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | AP1B1 | Homo sapiens | Q10567-3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NFIX | Homo sapiens | Q14938-5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NFIX | Homo sapiens | Q14938-5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NFIX | Homo sapiens | Q14938-5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF177 | Homo sapiens | Q13360-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF177 | Homo sapiens | Q13360-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF177 | Homo sapiens | Q13360-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TSGA13 | Homo sapiens | Q96PP4 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MBD3L1 | Homo sapiens | Q8WWY6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MBD3L1 | Homo sapiens | Q8WWY6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MBD3L1 | Homo sapiens | Q8WWY6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZFP57 | Homo sapiens | Q9NU63-3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZFP57 | Homo sapiens | Q9NU63-3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZFP57 | Homo sapiens | Q9NU63-3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM228A | Homo sapiens | Q86W67 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM228A | Homo sapiens | Q86W67 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM228A | Homo sapiens | Q86W67 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FRMD6 | Homo sapiens | Q96NE9-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PRR5L | Homo sapiens | Q6MZQ0 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PRR5L | Homo sapiens | Q6MZQ0 | 32296183 | |
|
Intra
|
MLH1 | P40692 | PRR5L | Homo sapiens | Q6MZQ0 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF212 | Homo sapiens | Q9UDV6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF212 | Homo sapiens | Q9UDV6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF212 | Homo sapiens | Q9UDV6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF474 | Homo sapiens | Q6S9Z5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF474 | Homo sapiens | Q6S9Z5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZNF474 | Homo sapiens | Q6S9Z5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CDKL5 | Homo sapiens | O76039 | 21653829 | |
|
Intra
|
MLH1 | P40692 | CCDC74B | Homo sapiens | Q96LY2-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CCDC74B | Homo sapiens | Q96LY2-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CCDC74B | Homo sapiens | Q96LY2-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NANOS3 | Homo sapiens | P60323-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NANOS3 | Homo sapiens | P60323-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NANOS3 | Homo sapiens | P60323-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | C9orf152 | Homo sapiens | Q5JTZ5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | C9orf152 | Homo sapiens | Q5JTZ5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | C9orf152 | Homo sapiens | Q5JTZ5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | LUC7L3 | Homo sapiens | O95232-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | LUC7L3 | Homo sapiens | O95232-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | SYF2 | Homo sapiens | O95926 | 32296183 | |
|
Intra
|
MLH1 | P40692 | SYF2 | Homo sapiens | O95926 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ISY1 | Homo sapiens | Q9ULR0 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ISY1 | Homo sapiens | Q9ULR0 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ISY1 | Homo sapiens | Q9ULR0 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MCM9 | Homo sapiens | Q9NXL9 | 33961781 | |
|
Intra
|
MLH1 | P40692 | PMS1 | Homo sapiens | P54277 | 33961781 | |
|
Intra
|
MLH1 | P40692 | PMS1 | Homo sapiens | P54277 | 11292842 | |
|
Intra
|
MLH1 | P40692 | PMS1 | Homo sapiens | P54277 | 34591612 | |
|
Intra
|
MLH1 | P40692 | PMS1 | Homo sapiens | P54277 | 25502805 | |
|
Intra
|
MLH1 | P40692 | PMS1 | Homo sapiens | P54277 | 11292842 | |
|
Intra
|
MLH1 | P40692 | KPNA2 | Homo sapiens | P52292 | 32296183 | |
|
Intra
|
MLH1 | P40692 | KPNA2 | Homo sapiens | P52292 | 31515488 | |
|
Intra
|
MLH1 | P40692 | KPNA2 | Homo sapiens | P52292 | 25416956 | |
|
Intra
|
MLH1 | P40692 | KPNA2 | Homo sapiens | P52292 | 32296183 | |
|
Intra
|
MLH1 | P40692 | KPNA2 | Homo sapiens | P52292 | 32296183 | |
|
Intra
|
MLH1 | P40692 | KPNA2 | Homo sapiens | P52292 | 25416956 | |
|
Intra
|
MLH1 | P40692 | BRIP1 | Homo sapiens | Q9BX63 | 17581638 | |
|
Intra
|
MLH1 | P40692 | BRIP1 | Homo sapiens | Q9BX63 | 33961781 | |
|
Intra
|
MLH1 | P40692 | BRIP1 | Homo sapiens | Q9BX63 | 34591612 | |
|
Intra
|
MLH1 | P40692 | BRIP1 | Homo sapiens | Q9BX63 | 25502805 | |
|
Intra
|
MLH1 | P40692 | BRIP1 | Homo sapiens | Q9BX63 | 17581638 | |
|
Intra
|
MLH1 | P40692 | FSCN1 | Homo sapiens | Q16658 | 20603015 | |
|
Intra
|
MLH1 | P40692 | ACTG1 | Homo sapiens | P63261 | 20706999 | |
|
Intra
|
MLH1 | P40692 | ACTG1 | Homo sapiens | P63261 | 20706999 | |
|
Intra
|
MLH1 | P40692 | SPTAN1 | Homo sapiens | Q13813 | 20706999 | |
|
Intra
|
MLH1 | P40692 | SPTAN1 | Homo sapiens | Q13813 | 20706999 | |
|
Intra
|
MLH1 | P40692 | SPTAN1 | Homo sapiens | Q13813 | 20706999 | |
|
Intra
|
MLH1 | P40692 | SPTAN1 | Homo sapiens | Q13813 | 20706999 | |
|
Intra
|
MLH1 | P40692 | HSPA8 | Homo sapiens | P11142 | 25502805 | |
|
Intra
|
MLH1 | P40692 | ANXA2 | Homo sapiens | P07355 | 20706999 | |
|
Intra
|
MLH1 | P40692 | ANXA2 | Homo sapiens | P07355 | 20706999 | |
|
Intra
|
MLH1 | P40692 | ANXA2 | Homo sapiens | P07355 | 20706999 | |
|
Intra
|
MLH1 | P40692 | ANXA2 | Homo sapiens | P07355 | 20706999 | |
|
Intra
|
MLH1 | P40692 | PSMA1 | Homo sapiens | P25786 | 25416956 | |
|
Intra
|
MLH1 | P40692 | MLH3 | Homo sapiens | Q9UHC1 | 11292842 | |
|
Intra
|
MLH1 | P40692 | MLH3 | Homo sapiens | Q9UHC1 | 33961781 | |
|
Intra
|
MLH1 | P40692 | MLH3 | Homo sapiens | Q9UHC1 | 11292842 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 25910212 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 25416956 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 25416956 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 25910212 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 25910212 | |
|
Intra
|
MLH1 | P40692 | MYOG | Homo sapiens | P15173 | 31515488 | |
|
Intra
|
MLH1 | P40692 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CDCA7L | Homo sapiens | Q96GN5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CDCA7L | Homo sapiens | Q96GN5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | CDCA7L | Homo sapiens | Q96GN5 | 32296183 | |
|
Intra
|
MLH1 | P40692 | KPNA5 | Homo sapiens | O15131 | 32296183 | |
|
Intra
|
MLH1 | P40692 | KPNA5 | Homo sapiens | O15131 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NELFA | Homo sapiens | Q9H3P2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NELFA | Homo sapiens | Q9H3P2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NELFA | Homo sapiens | Q9H3P2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | U2AF1 | Homo sapiens | Q01081 | 32296183 | |
|
Intra
|
MLH1 | P40692 | U2AF1 | Homo sapiens | Q01081 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MBD4 | Homo sapiens | O95243-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MBD4 | Homo sapiens | O95243-2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM90A1 | Homo sapiens | Q86YD7 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM90A1 | Homo sapiens | Q86YD7 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM90A1 | Homo sapiens | Q86YD7 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RSPH3 | Homo sapiens | Q86UC2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RSPH3 | Homo sapiens | Q86UC2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RSPH3 | Homo sapiens | Q86UC2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | BTBD2 | Homo sapiens | Q9BX70 | 32296183 | |
|
Intra
|
MLH1 | P40692 | BTBD2 | Homo sapiens | Q9BX70 | 32296183 | |
|
Intra
|
MLH1 | P40692 | BTBD2 | Homo sapiens | Q9BX70 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TMSB4X | Homo sapiens | P62328 | 17967441 | |
|
Intra
|
MLH1 | P40692 | TMSB4X | Homo sapiens | P62328 | 17967441 | |
|
Intra
|
MLH1 | P40692 | TMSB4X | Homo sapiens | P62328 | 20706999 | |
|
Intra
|
MLH1 | P40692 | TMSB4X | Homo sapiens | P62328 | 20706999 | |
|
Intra
|
MLH1 | P40692 | CTSB | Homo sapiens | P07858 | 20706999 | |
|
Intra
|
MLH1 | P40692 | CTSB | Homo sapiens | P07858 | 20706999 | |
|
Intra
|
MLH1 | P40692 | CTSB | Homo sapiens | P07858 | 20706999 | |
|
Intra
|
MLH1 | P40692 | CCDC33 | Homo sapiens | Q8N5R6 | 25910212 | |
|
Intra
|
MLH1 | P40692 | CCDC33 | Homo sapiens | Q8N5R6 | 25910212 | |
|
Intra
|
MLH1 | P40692 | CCDC33 | Homo sapiens | Q8N5R6 | 25910212 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61 | 21516116 | |
|
Intra
|
MLH1 | P40692 | CBY2 | Homo sapiens | Q8NA61 | 25416956 | |
|
Intra
|
MLH1 | P40692 | FRMD6 | Homo sapiens | Q96NE9 | 16189514 | |
|
Intra
|
MLH1 | P40692 | FAM50B | Homo sapiens | Q9Y247 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM50B | Homo sapiens | Q9Y247 | 32296183 | |
|
Intra
|
MLH1 | P40692 | FAM50B | Homo sapiens | Q9Y247 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NME4 | Homo sapiens | O00746 | 32296183 | |
|
Intra
|
MLH1 | P40692 | NME4 | Homo sapiens | O00746 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TASOR2 | Homo sapiens | Q5VWN6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TASOR2 | Homo sapiens | Q5VWN6 | 25910212 | |
|
Intra
|
MLH1 | P40692 | TASOR2 | Homo sapiens | Q5VWN6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | TASOR2 | Homo sapiens | Q5VWN6 | 25910212 | |
|
Intra
|
MLH1 | P40692 | TASOR2 | Homo sapiens | Q5VWN6 | 25910212 | |
|
Intra
|
MLH1 | P40692 | TASOR2 | Homo sapiens | Q5VWN6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZC3H11A | Homo sapiens | O75152 | 16189514 | |
|
Intra
|
MLH1 | P40692 | ZC3H11A | Homo sapiens | O75152 | 29892012 | |
|
Intra
|
MLH1 | P40692 | UBOX5 | Homo sapiens | O94941 | 16189514 | |
|
Intra
|
MLH1 | P40692 | ZMAT5 | Homo sapiens | Q9UDW3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZMAT5 | Homo sapiens | Q9UDW3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | ZMAT5 | Homo sapiens | Q9UDW3 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 31515488 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 25416956 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 25416956 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 21516116 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 32296183 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 25416956 | |
|
Intra
|
MLH1 | P40692 | RADX | Homo sapiens | Q6NSI4 | 32296183 | |
|
Intra
|
MLH1 | P40692 | SPATA8 | Homo sapiens | Q6RVD6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | SPATA8 | Homo sapiens | Q6RVD6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | SPATA8 | Homo sapiens | Q6RVD6 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MCM8 | Homo sapiens | Q9UJA3 | 33961781 | |
|
Intra
|
MLH1 | P40692 | MORN3 | Homo sapiens | Q6PF18 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MORN3 | Homo sapiens | Q6PF18 | 32296183 | |
|
Intra
|
MLH1 | P40692 | MORN3 | Homo sapiens | Q6PF18 | 32296183 |
MLH1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80226 | MLH1 Antibody (YA290) | WB, ICC/IF, IHC-P, IP, FC | Human, Mouse, Rat |
| HY-P80753 | MLH1 Antibody (YA703) | WB, ICC/IF | Human, Monkey |
| HY-P80753A | MLH1 Antibody (YA703)(PBS only) | WB, ICC/IF | Human, Monkey |
| HY-P84299 | MLH1 Antibody (YA3996) | WB, IHC-P, ICC/IF, ELISA | Human, Monkey |
| HY-P84299A | MLH1 Antibody (YA3996)(PBS only) | WB, IHC-P, ICC/IF, ELISA | Human, Monkey |
| HY-P85961 | MLH1 Antibody (YA5653) | IHC-P, WB, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Mismatch Repair Cancer Syndrome 1 |
|
|
| Colorectal Cancer, Hereditary Nonpolyposis, Type 2 |
|
|
| Muir-Torre Syndrome |
|
|
| Lynch Syndrome |
|
|
| Lynch Syndrome I |
|
|
| Colonic Benign Neoplasm |
|
|
| Familial Colorectal Cancer |
|
|
| Endometrial Cancer |
|
|
| Colorectal Cancer |
|
|
| Hereditary Breast Ovarian Cancer Syndrome |
|
|
| Bap1 Tumor Predisposition Syndrome |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Breast Cancer |
|
|
| Sebaceous Gland Neoplasm |
|
|
| Adenoma |
|
|
| Gastric Adenocarcinoma |
|
|
| Mismatch Repair Cancer Syndrome |
|
|
| Familial Adenomatous Polyposis |
|
|
| Biliary Tract Cancer |
|
|
| Neurofibromatosis |
|
|
| Ulcerative Colitis |
|
|
| Sebaceous Adenocarcinoma |
|
|
| Small Intestine Cancer |
|
|
| Endometrial Hyperplasia |
|
|
| Adenocarcinoma |
|
|
| Colorectal Cancer 2 |
|
|
| Sebaceous Adenoma |
|
|
| Cecum Carcinoma |
|
|
| Gallbladder Cancer |
|
|
| Rectum Cancer |
|
|
| Adenomyoma |
|
|
| Bilateral Breast Cancer |
|
|
| Keratoacanthoma |
|
|
| Lung Cancer |
|
|
| Colitis |
|
|
| Cervical Squamous Cell Carcinoma |
|
|
| Werner Syndrome |
|
|
| Jejunal Cancer |
|
|
| Skin Benign Neoplasm |
|
|
| Duodenum Adenocarcinoma |
|
|
| Ascending Colon Cancer |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Transitional Cell Carcinoma |
|
|
| Microinvasive Gastric Cancer |
|
|
| Rectosigmoid Cancer |
|
|
| Rhabdomyosarcoma |
|
|
| Spindle Cell Intraocular Melanoma |
|
|
| Gastric Cancer |
|
|
| Polyposis Syndrome, Hereditary Mixed, 1 |
|
|
| Colorectal Cancer, Hereditary Nonpolyposis, Type 5 |
|
|
| Ovarian Cancer |
|
|
| Ureter, Cancer Of |
|
|
| Female Reproductive Endometrioid Cancer |
|
|
| Li-Fraumeni Syndrome |
|
|
| Adenosquamous Colon Carcinoma |
|
|
| Ampulla Of Vater Cancer |
|
|
| Descending Colon Cancer |
|
|
| Small Intestine Adenocarcinoma |
|
|
| Neurofibromatosis, Type I |
|
|
| Jejunal Adenocarcinoma |
|
|
| Fallopian Tube Carcinoma |
|
|
| Alveolar Soft Part Sarcoma |
|
|
| Familial Adenomatous Polyposis 2 |
|
|
| Dysplastic Nevus Syndrome |
|
|
| Female Breast Cancer |
|
|
| Villous Adenoma |
|
|
| Renal Pelvis Carcinoma |
|
|
| Diffuse Gastric Cancer |
|
|
| Infertility |
|
|
| Friedreich Ataxia |
|
|
| Extrahepatic Bile Duct Adenoma |
|
|
| Diffuse Gastric And Lobular Breast Cancer Syndrome |
|
|
| Mucinous Adenocarcinoma |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
| Transverse Colon Cancer |
|
|
| Glioblastoma |
|
|
| Cowden Syndrome 1 |
|
|
| Colorectal Cancer, Hereditary Nonpolyposis, Type 4 |
|
|
| Appendix Carcinoid Tumor |
|
|
| Duodenum Cancer |
|
|
| Colorectal Adenoma |
|
|
| Oligodendroglioma |
|
|
| Juvenile Polyposis Syndrome |
|
|
| Signet Ring Cell Adenocarcinoma |
|
|
| Intestinal Benign Neoplasm |
|
|
| Rectosigmoid Junction Neoplasm |
|
|
| Bladder Cancer |
|
|
| Rectal Benign Neoplasm |
|
|
| Gastrointestinal Adenoma |
|
|
| Duodenum Disease |
|
|
| Colon Adenoma |
|
|
| Basal Cell Carcinoma |
|
|
| Skin Squamous Cell Carcinoma |
|
|
| Sigmoid Neoplasm |
|
|
| Medullary Colon Carcinoma |
|
|
| Fallopian Tube Serous Adenocarcinoma |
|
|
| Uterine Body Mixed Cancer |
|
|
| Endometrial Adenocarcinoma |
|
|
| Colorectal Adenocarcinoma |
|
|
| Endometrioid Ovary Carcinoma |
|
|
| Hereditary Mixed Polyposis Syndrome |
|
|
| Pancreatic Cancer |
|
|
| Colorectal Cancer, Hereditary Nonpolyposis, Type 6 |
|
|
| Colon Adenocarcinoma |
|
|
| Rectum Signet Ring Adenocarcinoma |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Inflammatory Bowel Disease |
|
|
| Uterine Corpus Cancer |
|
|
| Endocrine Gland Cancer |
|
|
| Serous Cystadenocarcinoma |
|
|
| Cowden Syndrome |
|
|
| Mixed Cell Type Cancer |
|
|
| Lymphangioma |
|
|
| Hematologic Cancer |
|
|
| Uterine Carcinosarcoma |
|
|
| Xeroderma Pigmentosum, Variant Type |
|
|
| Rectum Adenocarcinoma |
|
|
| Gastric Body Carcinoma |
|
|
| Uterine Benign Neoplasm |
|
|
| Lentigines |
|
|
| Melanoma |
|
|
| Neural Tube Defects |
|
|
| Ovary Adenocarcinoma |
|
|
| Autosomal Dominant Intellectual Developmental Disorder 8 |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Pancreatic Signet Ring Cell Adenocarcinoma |
|
|
| Prostate Cancer |
|
|
| Retinal Melanoma |
|
|
| Esophageal Cancer |
|
|
| Aplastic Anemia |
|
|
| Melanoma, Cutaneous Malignant 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | MLH1 | VGNC | VGNC:74880 |
| Bos taurus | MLH1 | VGNC | VGNC:31497 |
| Rattus norvegicus | MLH1 | RGD | RGD:620937 |
| Mus musculus | MLH1 | MGD | MGI:101938 |
| Felis catus | MLH1 | VGNC | VGNC:68268 |
| Canis familiaris | MLH1 | VGNC | VGNC:43257 |
| Others | MLH1 | NCBI |