BTBD2 - BTB domain containing 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55643

About BTBD2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,985,448-2,015,714 (from NCBI)

This gene has 11 transcripts (splice variants), 222 orthologues and 11 paralogues. Ubiquitous expression in ovary (RPKM 26.1), kidney (RPKM 19.8) and 25 other tissues.

Summary

The C-terminus of the protein encoded by this gene binds Topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]

BTBD2 Products (1)

mRNA Protein Name
NM_017797.4 NP_060267.2 BTB/POZ domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12878161 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
12878161 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTBD2 Protein Structure

BTB

BTB: BTB/POZ domain (110 - 216)

BACK

BACK: BTB And C-terminal Kelch (225 - 326)

PHR

PHR: PHR domain (375 - 525)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

BTB/POZ domain-containing protein 2

  • BTB (POZ) domain containing 2

BTBD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BTBD2 Q9BX70 NGB Homo sapiens Q9NPG2
Validated Y2H
32296183
Intra
BTBD2 Q9BX70 TP53 Homo sapiens P04637
Y2H Pooling
16169070
Intra
BTBD2 Q9BX70 COPS6 Homo sapiens Q7L5N1
Y2H Pooling
16169070
Intra
BTBD2 Q9BX70 OSGIN1 Homo sapiens Q9UJX0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01655 BTBD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BTBD2 VGNC VGNC:70314
Bos taurus BTBD2 VGNC VGNC:26589
Mus musculus BTBD2 MGD MGI:1933831
Canis familiaris BTBD2 VGNC VGNC:54579
Felis catus BTBD2 VGNC VGNC:102010
Rattus norvegicus BTBD2 RGD RGD:1566094
Others BTBD2 NCBI