2. Gene
  3. COPS6 - COP9 signalosome subunit 6 Gene

COPS6 - COP9 signalosome subunit 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CSN6; MOV34-34KD

Gene ID: 10980 | Gene type: protein coding

About COPS6

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,088,969-100,092,187 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 33.2), testis (RPKM 32.7) and 25 other tissues.

Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

COPS6 Products(1)

mRNA Protein Name
NM_006833.5 NP_006824.2 COP9 signalosome complex subunit 6

COPS6 Protein Structure

JAB

JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease (40 - 147)

MitMem_reg

MitMem_reg: Maintenance of mitochondrial structure and function (193 - 308)

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  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 6

COP9 constitutive photomorphogenic homolog subunit 6

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V

Xp5

Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

Xpe

Xp, Group E

Xeroderma Pigmentosum, Type 5

Xeroderma Pigmentosum Complementation Group E

XP-E

Xp Group E
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03031 COPS6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus COPS6 VGNC VGNC:27603
Mus musculus COPS6 MGD MGI:1349439
Macaca mulatta COPS6 VGNC VGNC:71286
Rattus norvegicus COPS6 RGD RGD:1309919
Canis familiaris COPS6 VGNC VGNC:39512