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COPS6 - COP9 signalosome subunit 6 Gene

Also Known as CSN6; MOV34-34KD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10980

About COPS6

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,088,969-100,092,187 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 33.2), testis (RPKM 32.7) and 25 other tissues.

Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

COPS6 Products (1)

mRNA	Protein	Name
NM_006833.5	NP_006824.2	COP9 signalosome complex subunit 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein deneddylation	IDA IDA: Inferred from direct assay	19141280	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of COP9 signalosome	IPI IPI: Inferred from physical interaction	25043011	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24421388	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24421388	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS6 Protein Structure

JAB

MitMem_reg

0
100
200
300
327 a.a.

Protein Preferred Names	Protein Names
COP9 signalosome complex subunit 6	COP9 constitutive photomorphogenic homolog subunit 6

COPS6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COPS6	Q7L5N1	COP1	Homo sapiens	Q8NHY2	Anti Bait CoIP	21625211
Intra	COPS6	Q7L5N1	COP1	Homo sapiens	Q8NHY2	Anti Tag CoIP	21625211
Intra	COPS6	Q7L5N1	BTRC	Homo sapiens	Q9Y297	TAP	21145461
Intra	COPS6	Q7L5N1	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	19615732
Intra	COPS6	Q7L5N1	COPS3	Homo sapiens	Q9UNS2	TAP	21145461
Intra	COPS6	Q7L5N1	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	33961781
Intra	COPS6	Q7L5N1	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	28514442
Intra	COPS6	Q7L5N1	COPS3	Homo sapiens	Q9UNS2	Pull Down	25043011
Intra	COPS6	Q7L5N1	COPS3	Homo sapiens	Q9UNS2	Anti Bait CoIP	24421388
Intra	COPS6	Q7L5N1	SFN	Homo sapiens	P31947	Pull Down	21625211
Intra	COPS6	Q7L5N1	SFN	Homo sapiens	P31947	Anti Bait CoIP	21625211
Intra	COPS6	Q7L5N1	SFN	Homo sapiens	P31947	Anti Tag CoIP	21625211
Intra	COPS6	Q7L5N1	COPS5	Homo sapiens	Q92905	TAP	21145461
Intra	COPS6	Q7L5N1	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	33961781
Intra	COPS6	Q7L5N1	COPS5	Homo sapiens	Q92905	Anti Bait CoIP	21625211
Intra	COPS6	Q7L5N1	COPS5	Homo sapiens	Q92905	Pull Down	25043011
Intra	COPS6	Q7L5N1	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	28514442
Intra	COPS6	Q7L5N1	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	19615732
Intra	COPS6	Q7L5N1	BTBD2	Homo sapiens	Q9BX70	Anti Tag CoIP	19615732
Intra	COPS6	Q7L5N1	BTBD2	Homo sapiens	Q9BX70	TAP	21145461
Intra	COPS6	Q7L5N1	BTBD2	Homo sapiens	Q9BX70	Anti Tag CoIP	33961781
Intra	COPS6	Q7L5N1	BTBD2	Homo sapiens	Q9BX70	Anti Tag CoIP	28514442
Intra	COPS6	Q7L5N1	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	Anti Tag CoIP	33961781
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	Y2H Prey Pooling	32296183
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	Pull Down	25043011
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	Y2H Array	32296183
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	Anti Tag CoIP	19615732
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	Validated Y2H	32296183
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	TAP	21145461
Intra	COPS6	Q7L5N1	COPS4	Homo sapiens	Q9BT78	Anti Tag CoIP	28514442
Intra	COPS6	Q7L5N1	SHC3	Homo sapiens	Q92529	Validated Y2H	32296183
Intra	COPS6	Q7L5N1	MAPK1	Homo sapiens	P28482	Protein Kinase Assay	26267535
Intra	COPS6	Q7L5N1	MAPK1	Homo sapiens	P28482	Anti Bait CoIP	26267535

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Complementation Group E	Xeroderma Pigmentosum V Xp5 Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype Xpe Xp, Group E Xeroderma Pigmentosum, Type 5 Xeroderma Pigmentosum Complementation Group E XP-E Xp Group E

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03031	COPS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	COPS6	VGNC	VGNC:27603
Mus musculus	COPS6	MGD	MGI:1349439
Macaca mulatta	COPS6	VGNC	VGNC:71286
Rattus norvegicus	COPS6	RGD	RGD:1309919
Canis familiaris	COPS6	VGNC	VGNC:39512
Others	COPS6	NCBI