COPS3 - COP9 signalosome subunit 3 Gene

Also Known as CSN3; SGN3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8533

About COPS3

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,246,616-17,281,246 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.1), bone marrow (RPKM 38.5) and 25 other tissues.

Summary

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

COPS3 Products (7)

mRNA Protein Name
NM_001199125.1 NP_001186054.1 COP9 signalosome complex subunit 3 isoform 2
NM_001316354.2 NP_001303283.1 COP9 signalosome complex subunit 3 isoform 3
NM_001316355.2 NP_001303284.1 COP9 signalosome complex subunit 3 isoform 4
NM_001316356.2 NP_001303285.1 COP9 signalosome complex subunit 3 isoform 5
NM_001316357.2 NP_001303286.1 COP9 signalosome complex subunit 3 isoform 6
NM_001316358.2 NP_001303287.1 COP9 signalosome complex subunit 3 isoform 6
NM_003653.4 NP_003644.2 COP9 signalosome complex subunit 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10777491 GOA
Biological Process GO Annotation Evidence References Source
involved in protein deneddylation IDA
IDA: Inferred from direct assay
19141280 GOA
involved in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: Inferred from mutant phenotype
15861129 GOA
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
part of COP9 signalosome IPI
IPI: Inferred from physical interaction
25043011 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
24421388 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24421388 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15861129 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS3 Protein Structure

PCI

PCI: PCI domain (259 - 361)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 3

  • COP9 complex subunit 3

COPS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COPS3 Q9UNS2 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra
COPS3 Q9UNS2 YARS1 Homo sapiens P54577
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 YARS1 Homo sapiens P54577
Y2H Array
32814053
Intra
COPS3 Q9UNS2 YARS1 Homo sapiens P54577
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Pull Down
25043011
Intra
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Anti Tag CoIP
24421388
Intra
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Anti Bait CoIP
24421388
Intra
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Pull Down
20399188
Intra
COPS3 Q9UNS2 COPS2 Homo sapiens P61201
Anti Tag CoIP
33961781
Intra
COPS3 Q9UNS2 RAB7A Homo sapiens P51149
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 RAB7A Homo sapiens P51149
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 RAB7A Homo sapiens P51149
Y2H Array
32814053
Intra
COPS3 Q9UNS2 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra
COPS3 Q9UNS2 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 ERCC8 Homo sapiens Q13216-2
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 ERCC8 Homo sapiens Q13216-2
Y2H Array
32814053
Intra
COPS3 Q9UNS2 ERCC8 Homo sapiens Q13216-2
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
COPS3 Q9UNS2 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 COPS8 Homo sapiens Q99627
Pull Down
25043011
Intra
COPS3 Q9UNS2 COPS8 Homo sapiens Q99627
Pull Down
20399188
Intra
COPS3 Q9UNS2 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
Intra
COPS3 Q9UNS2 PANK2 Homo sapiens Q9BZ23-2
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 PANK2 Homo sapiens Q9BZ23-2
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 PANK2 Homo sapiens Q9BZ23-2
Y2H Array
32814053
Intra
COPS3 Q9UNS2 TTBK2 Homo sapiens Q6IQ55-3
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 TTBK2 Homo sapiens Q6IQ55-3
Y2H Array
32814053
Intra
COPS3 Q9UNS2 TTBK2 Homo sapiens Q6IQ55-3
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 SOS1 Homo sapiens Q07889
Y2H
30631038
Intra
COPS3 Q9UNS2 SOS1 Homo sapiens Q07889
Pull Down
30631038
Intra
COPS3 Q9UNS2 DDB1 Homo sapiens Q16531
Anti Tag CoIP
33961781
Intra
COPS3 Q9UNS2 DDB1 Homo sapiens Q16531
Y2H
10777491
Intra
COPS3 Q9UNS2 LMNA Homo sapiens P02545-2
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 LMNA Homo sapiens P02545-2
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 LMNA Homo sapiens P02545-2
Y2H Array
32814053
Intra
COPS3 Q9UNS2 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
COPS3 Q9UNS2 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra
COPS3 Q9UNS2 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
COPS3 Q9UNS2 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Anti Tag CoIP
24421388
Intra
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Anti Tag CoIP
33961781
Intra
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Pull Down
25043011
Intra
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Anti Bait CoIP
24421388
Intra
COPS3 Q9UNS2 COPS6 Homo sapiens Q7L5N1
Pull Down
20399188
Intra
COPS3 Q9UNS2 TOR1A Homo sapiens O14656
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 TOR1A Homo sapiens O14656
Y2H Array
32814053
Intra
COPS3 Q9UNS2 TOR1A Homo sapiens O14656
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Pull Down
25043011
Intra
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Anti Tag CoIP
24421388
Intra
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Anti Bait CoIP
24421388
Intra
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Pull Down
20399188
Intra
COPS3 Q9UNS2 COPS5 Homo sapiens Q92905
Anti Tag CoIP
33961781
Intra
COPS3 Q9UNS2 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
COPS3 Q9UNS2 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra
COPS3 Q9UNS2 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 TTR Homo sapiens P02766
Y2H Array
32814053
Intra
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Anti Bait CoIP
24421388
Intra
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Pull Down
20399188
Intra
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Anti Tag CoIP
28514442
Intra
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Anti Tag CoIP
33961781
Intra
COPS3 Q9UNS2 COPS7A Homo sapiens Q9UBW8
Pull Down
25043011
Intra
COPS3 Q9UNS2 HEXB Homo sapiens P07686
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 HEXB Homo sapiens P07686
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 HEXB Homo sapiens P07686
Y2H Array
32814053
Intra
COPS3 Q9UNS2 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
COPS3 Q9UNS2 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 UCHL1 Homo sapiens P09936
Y2H Array
32814053
Intra
COPS3 Q9UNS2 UCHL1 Homo sapiens P09936
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 UCHL1 Homo sapiens P09936
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Y2H Array
32814053
Intra
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 PHYH Homo sapiens O14832
Anti Bait CoIP
17353931
Intra
COPS3 Q9UNS2 GARS1 Homo sapiens P41250
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 GARS1 Homo sapiens P41250
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 GARS1 Homo sapiens P41250
Y2H Array
32814053
Intra
COPS3 Q9UNS2 SNCB Homo sapiens Q16143
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 SNCB Homo sapiens Q16143
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 SNCB Homo sapiens Q16143
Y2H Array
32814053
Intra
COPS3 Q9UNS2 ASPA Homo sapiens P45381
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 ASPA Homo sapiens P45381
Y2H Array
32814053
Intra
COPS3 Q9UNS2 ASPA Homo sapiens P45381
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 PRPH Homo sapiens P41219
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 PRPH Homo sapiens P41219
Y2H Array
32814053
Intra
COPS3 Q9UNS2 PRPH Homo sapiens P41219
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 DBH Homo sapiens P09172
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 DBH Homo sapiens P09172
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 DBH Homo sapiens P09172
Y2H Array
32814053
Intra
COPS3 Q9UNS2 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Intra
COPS3 Q9UNS2 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
COPS3 Q9UNS2 PEX1 Homo sapiens O43933
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

COPS3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82446 COPS3 Antibody (YA2191) WB, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Bone Angioendothelial Sarcoma

  • Osseous Hemangiosarcoma

  • Bone Angiosarcoma
Xeroderma Pigmentosum, Complementation Group E

  • Xeroderma Pigmentosum V

  • Xp5

  • Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

  • Xpe

  • Xp, Group E

  • Xeroderma Pigmentosum, Type 5

  • Xeroderma Pigmentosum Complementation Group E

  • XP-E

  • Xp Group E
Parosteal Osteosarcoma

  • Juxtacortical Osteosarcoma

  • Parosteal Osteogenic Sarcoma

  • Osteosarcoma, Juxtacortical
Peripheral Osteosarcoma

  • Surface Osteosarcoma

  • Bone Surface Osteosarcoma
Telangiectatic Osteogenic Sarcoma

  • Telangiectatic Osteosarcoma
Conventional Osteosarcoma

  • Intracortical Osteosarcoma

  • Conventional Central Osteosarcoma

  • Intracortical Osteogenic Sarcoma

  • Medullary Osteosarcoma
Bone Osteosarcoma

  • Osteosarcoma Of Bone

  • Primary Osteosarcoma Of Bone
Potocki-Lupski Syndrome

  • PTLS

  • Chromosome 17p11.2 Duplication Syndrome

  • 17p11.2 Microduplication Syndrome

  • Duplication 17p11.2 Syndrome

  • Trisomy 17p11.2

  • Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))

  • 17p11.2 Duplication Syndrome

  • Dup(17)(P11.2p11.2)

  • Pls

  • Chromosome 17, Trisomy 17p11 2
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03028 COPS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus COPS3 VGNC VGNC:61088
Rattus norvegicus COPS3 RGD RGD:1303002
Macaca mulatta COPS3 VGNC VGNC:71316
Mus musculus COPS3 MGD MGI:1349409
Canis familiaris COPS3 VGNC VGNC:39510
Bos taurus COPS3 VGNC VGNC:27600
Others COPS3 NCBI