COPS3 - COP9 signalosome subunit 3 Gene

Homo sapiens

Also known as CSN3; SGN3

Gene ID: 8533 | Gene type: protein coding

About COPS3

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,246,616-17,281,246 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.1), bone marrow (RPKM 38.5) and 25 other tissues.

Summary

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

COPS3 Products(7)

mRNA	Protein	Name
NM_001199125.1	NP_001186054.1	COP9 signalosome complex subunit 3 isoform 2
NM_001316354.2	NP_001303283.1	COP9 signalosome complex subunit 3 isoform 3
NM_001316355.2	NP_001303284.1	COP9 signalosome complex subunit 3 isoform 4
NM_001316356.2	NP_001303285.1	COP9 signalosome complex subunit 3 isoform 5
NM_001316357.2	NP_001303286.1	COP9 signalosome complex subunit 3 isoform 6
NM_001316358.2	NP_001303287.1	COP9 signalosome complex subunit 3 isoform 6
NM_003653.4	NP_003644.2	COP9 signalosome complex subunit 3 isoform 1

COPS3 Protein Structure

PCI

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

COP9 signalosome complex subunit 3

COP9 complex subunit 3

Related Diseases

Diseases

Alias

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Parosteal Osteosarcoma

Juxtacortical Osteosarcoma	Parosteal Osteogenic Sarcoma
Osteosarcoma, Juxtacortical

Peripheral Osteosarcoma

Surface Osteosarcoma

Bone Surface Osteosarcoma

Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma

Conventional Osteosarcoma

Intracortical Osteosarcoma	Conventional Central Osteosarcoma
Intracortical Osteogenic Sarcoma	Medullary Osteosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Potocki-Lupski Syndrome

PTLS	Chromosome 17p11.2 Duplication Syndrome
17p11.2 Microduplication Syndrome	Duplication 17p11.2 Syndrome
Trisomy 17p11.2	Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))
17p11.2 Duplication Syndrome	Dup(17)(P11.2p11.2)
Pls	Chromosome 17, Trisomy 17p11 2

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03028	COPS3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	COPS3	VGNC	VGNC:61088
Rattus norvegicus	COPS3	RGD	RGD:1303002
Macaca mulatta	COPS3	VGNC	VGNC:71316
Mus musculus	COPS3	MGD	MGI:1349409
Canis familiaris	COPS3	VGNC	VGNC:39510
Bos taurus	COPS3	VGNC	VGNC:27600

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