YARS1 - tyrosyl-tRNA synthetase 1 Gene

Also Known as YRS; YTS; YARS; TYRRS; CMTDIC; IMNEPD2

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 8565

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

YARS1 Products (1)

mRNA Protein Name
XM_054339332.1 XP_054195307.1 tyrosine--tRNA ligase, cytoplasmic isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24965446 GOA
enables small molecule binding IDA
IDA: Inferred from direct assay
25533949 GOA
enables tyrosine-tRNA ligase activity IDA
IDA: Inferred from direct assay
22291016 GOA
Biological Process GO Annotation Evidence References Source
involved in response to starvation IDA
IDA: Inferred from direct assay
25533949 GOA
involved in tyrosyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
25533949 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
25533949 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
22291016 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
22291016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine--tRNA ligase, cytoplasmic

  • tyrosine tRNA ligase 1, cytoplasmic

  • tyrosyl--tRNA ligase

  • tyrosyl-tRNA synthetase, cytoplasmic

YARS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
YARS1 P54577 PARP1 Homo sapiens P09874
Anti Bait CoIP
25533949
Intra
YARS1 P54577 PARP1 Homo sapiens P09874
Pull Down
25533949
Cross: Cross-species interaction Intra: Intraspecies interaction

YARS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811221 Tyrosyl-tRNA Synthetase Antibody WB, IHC-P Human, Mouse, Rat