Tyrosyl-tRNA Synthetase Antibody
(Synonyms: YARS, YARS1, Tyrosyl-tRNA synthetase, TyrRS)Tyrosyl-tRNA Synthetase Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Tyrosyl-tRNA Synthetase.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
Tyrosyl-tRNA Synthetase Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Tyrosyl-tRNA Synthetase.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 59 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 59 kDa
Synthetic peptide corresponding to the C-term region of human Tyrosyl-tRNA Synthetase.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Tyrosyl-tRNA Synthetase is a Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1[1].
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Subcellular Localization
Cytoplasm; Nucleus
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Isoforms & Post-Translational Modification
Tyrosyl-tRNA Synthetase has an amino acid length of 528, molecular weight is 59143 Da.
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Subunit
Homodimer.
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SwissProt ID
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Synonyms
YARS, YARS1, Tyrosyl-tRNA synthetase, TyrRS
Documentation
References
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