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COPS8 - COP9 signalosome subunit 8 Gene

Also Known as COP9; CSN8; SGN8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10920

About COPS8

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,085,889-237,100,474 (from NCBI)

This gene has 7 transcripts (splice variants) and 141 orthologues. Ubiquitous expression in brain (RPKM 28.1), testis (RPKM 22.3) and 25 other tissues.

Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

COPS8 Products (2)

mRNA	Protein	Name
NM_006710.5	NP_006701.1	COP9 signalosome complex subunit 8 isoform 1
NM_198189.3	NP_937832.1	COP9 signalosome complex subunit 8 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20399188	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of NF-kappaB-inducing kinase activity	IMP IMP: Inferred from mutant phenotype	22992343	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23689509	GOA
involved in protein deneddylation	IDA IDA: Inferred from direct assay	19141280	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9535219	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	9535219	GOA
part of COP9 signalosome	IPI IPI: Inferred from physical interaction	25043011	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24421388	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24421388	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9535219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS8 Protein Structure

CSN8_PSD8_EIF3K

0
100
209 a.a.

Protein Preferred Names	Protein Names
COP9 signalosome complex subunit 8	COP9 constitutive photomorphogenic homolog subunit 8

COPS8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COPS8	Q99627	GPS1	Homo sapiens	Q13098-7	Pull Down	25043011
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Complementation	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	TAP	27173435
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Pull Down	25043011
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Y2H Array	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	MAPPIT	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	33961781
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	28514442
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Y2H Prey Pooling	32296183
Intra	COPS8	Q99627	COPS3	Homo sapiens	Q9UNS2	Validated Y2H	32296183
Intra	COPS8	Q99627	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	COPS8	Q99627	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

COPS8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81934	COPS8 Antibody (YA1679)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P81934A	COPS8 Antibody (YA1679)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Complementation Group E	Xeroderma Pigmentosum V Xp5 Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype Xpe Xp, Group E Xeroderma Pigmentosum, Type 5 Xeroderma Pigmentosum Complementation Group E XP-E Xp Group E
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03032	COPS8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	COPS8	VGNC	VGNC:71334
Mus musculus	COPS8	MGD	MGI:1915363
Felis catus	COPS8	VGNC	VGNC:61092
Bos taurus	COPS8	VGNC	VGNC:27606
Rattus norvegicus	COPS8	RGD	RGD:1311404
Others	COPS8	NCBI