SOS1 - SOS Ras/Rac guanine nucleotide exchange factor 1 Gene

Also Known as GF1; HGF; NS4; GGF1; GINGF; SOS-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6654

About SOS1

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,981,549-39,124,868 (from NCBI)

This gene has 20 transcripts (splice variants), 201 orthologues, 24 paralogues and is associated with 5 phenotypes. Ubiquitous expression in fat (RPKM 10.4), ovary (RPKM 10.2) and 25 other tissues.

Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for Ras proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates Ras proteins. The product of this gene may regulate Ras proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]

SOS1 Products (6)

mRNA	Protein	Name
NM_001382394.1	NP_001369323.1	son of sevenless homolog 1 isoform 2
NM_001382395.1	NP_001369324.1	son of sevenless homolog 1 isoform 3
NM_005633.4	NP_005624.2	son of sevenless homolog 1 isoform 1
NM_001382394.1	NP_001369323.1	son of sevenless homolog 1 isoform 2
NM_001382395.1	NP_001369324.1	son of sevenless homolog 1 isoform 3
NM_005633.4	NP_005624.2	son of sevenless homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	EXP EXP: Inferred from Experiment	1371879	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	1371879	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	27056844	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7527391	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Ras protein signal transduction	IDA IDA: Inferred from direct assay	23027131	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	7737275	GOA
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9054499	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23027131	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of GTPase complex	IPI IPI: Inferred from physical interaction	25695162	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17515907	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOS1 Protein Structure

Histone

RhoGEF

RasGEF_N

RasGEF

0
300
600
900
1200
1333 a.a.

Protein Preferred Names	Protein Names
son of sevenless homolog 1	gingival fibromatosis, hereditary, 1

SOS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SOS1	Q07889	NEB	Homo sapiens	P20929	Fluorescence Spectr	12482578
Intra	SOS1	Q07889	NEB	Homo sapiens	P20929	CD	12482578
Intra	SOS1	Q07889	NEB	Homo sapiens	P20929	NMR	12482578
Intra	SOS1	Q07889	EGFR	Homo sapiens	P00533	Anti Bait CoIP	26005835
Intra	SOS1	Q07889	HCK	Homo sapiens	P08631	PLA	23397142
Intra	SOS1	Q07889	HCK	Homo sapiens	P08631	Pull Down	12029088
Intra	SOS1	Q07889	HCK	Homo sapiens	P08631	Fluorescence Spectr	17141806
Intra	SOS1	Q07889	HRAS	Homo sapiens	P01112	X-Ray Diffraction	12628188
Intra	SOS1	Q07889	HRAS	Homo sapiens	P01112	GDP/GTP Exchange	20133692
Intra	SOS1	Q07889	HRAS	Homo sapiens	P01112	SPR	17084389
Intra	SOS1	Q07889	HRAS	Homo sapiens	P01112	GDP/GTP Exchange	18454158
Intra	SOS1	Q07889	COPS3	Homo sapiens	Q9UNS2	Anti Bait CoIP	30631038
Intra	SOS1	Q07889	GRB2	Homo sapiens	P62993	Y2H	21988832
Intra	SOS1	Q07889	GRB2	Homo sapiens	P62993	Anti Bait CoIP	16520382
Intra	SOS1	Q07889	GRB2	Homo sapiens	P62993	ITC	19323566
Intra	SOS1	Q07889	GRB2	Homo sapiens	P62993	CoIP	14679214
Intra	SOS1	Q07889	q5tcz1-2	Homo sapiens	Q5TCZ1-2	Peptide Array	19464300
Intra	SOS1	Q07889	q5tcz1-2	Homo sapiens	Q5TCZ1-2	Pull Down	19464300
Intra	SOS1	Q07889	PLCG1	Homo sapiens	P19174	Peptide Array	17474147
Intra	SOS1	Q07889	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147
Intra	SOS1	Q07889	PIK3R1	Homo sapiens	P27986	PLA	25241761
Intra	SOS1	Q07889	CRK	Homo sapiens	P46108	PLA	25241761
Intra	SOS1	Q07889	CRK	Homo sapiens	P46108	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

SOS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83568	SOS1 Antibody (YA3313)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Noonan Syndrome 4	NS4 Noonan Syndrome, Type 4
Fibromatosis, Gingival, 1	GINGF1 Ggf1 Fibromatosis, Gingival, Hereditary Hgf Hereditary Gingival Fibromatosis Gingf Gingival Fibromatosis, 1 Fibromatosis Gingival, Hereditary, 1 Hgf1 Hereditary Gingival Fibromatosis, 1
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Pulmonic Stenosis	Valvular Pulmonic Stenosis Congenital Pulmonary Valvar Stenosis Congenital Stenosis Of Pulmonary Valve Pulmonary Valve Stenosis Pulmonary Stenosis Congenital Pulmonary Valve Stricture Congenital Pulmonary Valve Stenosis
Gingival Fibromatosis	Hereditary Gingival Fibromatosis Hereditary Gingival Hyperplasia Autosomal Dominant Gingival Fibromatosis Autosomal Dominant Gingival Hyperplasia Fibromatosis, Gingival, Hereditary Fibromatosis, Gingival
Noonan Syndrome 3	NS3 Noonan Syndrome, Type 3
Nuchal Bleb, Familial	Fetal Cystic Hygroma Cystic Hygroma, Fetal Fch Lymphangioma, Cystic
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Pseudo-Turner Syndrome	Noonan Syndrome
Noonan Syndrome And Noonan-Related Syndrome
Fibromatosis
Villonodular Synovitis	Pigmented Villonodular Synovitis
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
46,Xy Partial Gonadal Dysgenesis	46,Xy Pgd 46,Xy Partial Testicular Dysgenesis
Cardiofaciocutaneous Syndrome 1	Cardiofaciocutaneous Syndrome Cfc Syndrome Cardio-Facio-Cutaneous Syndrome CFC1 Cfcs Cardio-Facial-Cutaneous Syndrome Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure Cardiofaciocutaneous Syndrome, Type 1
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Skin Granular Cell Tumor	Granular Cell Neoplasm Of The Skin Granular Cell Tumor Of Skin Granular Cell Tumour Of Skin Skin Granular Cell Tumour
Keratosis Pilaris Atrophicans Faciei
Gingival Overgrowth	Gingival Enlargement Gingival Hyperplasia Gingival Bulge Gingival Enlargement Nos Gingival Hypertrophy Gum Hypertrophy Hyperplasia Gum Gingival Thickening Hyperplasia Of Gingiva Hypertrophy Of Gingiva Hypertrophy Of Mucous Membrane Of Gums
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pulmonary Valve Disease	Pulmonary Valve Disorder
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Pulmonary Valve Stenosis	Valvular Pulmonary Stenosis Heart Valve Pulmonary Stenosis Valvar Pulmonary Stenosis Valvate Pulmonary Stenosis Pulmonary Stenosis Pulmonary Valve Stricture Pulmonic Valve Stenosis Ps - [Pulmonary Valve Stenosis] Pvs - [Pulmonary Valve Stenosis] Pulmonary Valvular Stricture Pulmonary Valvular Stenosis Pulmonary Valvular Obstruction Pulmonary Valve Obstruction Obstructed Pulmonary Valve
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Neuroma
Noonan Syndrome-Like Disorder With Loose Anagen Hair	Noonan-Like Syndrome With Loose Anagen Hair Mazzanti Syndrome Ns/Lah
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Neurofibromatosis-Noonan Syndrome	NFNS Neurofibromatosis Type 1 Neurofibromatosis With Noonan Phenotype Nf1 Von Recklinghausen Disease Neurofibromatosis Type 1-Noonan Syndrome Noonan Neurofibromatosis Syndrome Recklinghausen'S Disease Noonan-Neurofibromatosis Syndrome Fibromatosis Multiple Non Ossifying Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots Jaffe Campanacci Syndrome Type 1 Neurofibromatosis Neurofibromatosis 1 Peripheral Neurofibromatosis Recklinghausen Disease, Nerve Jaffe-Campanacci Syndrome
Pigmented Villonodular Synovitis	Diffuse Giant Cell Tumor Of Tenosynovium Villous Tenosynovitis Diffuse Pigmented Villonodular Synovitis Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Localized Pigmented Villonodular Synovitis Tgct Tsgct Tenosynovial Giant Cell Tumor Tenosynovial Giant Cell Tumors Synovitis Pigmented Villonodular Synovitis, Pigmented Villonodular Fibrous Histiocytoma Of Tendon Sheath Testicular Germ Cell Tumor Chronic Haemorrhagic Villous Synovitis Pvns - [Pigmented Villonodular Synovitis] Villonodular Synovitis
Gingival Disease	Gingival Diseases Gum Disease Gingival Disorder Gingivitis And Periodontal Diseases
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Cystic Lymphangioma	Cystic Hygroma Cavernous Lymphangioma Macrocystic Lymphatic Malformation Cavernous Lymphatic Malformation Macrocystic Lymphangioma Lymphangioma, Cystic
Metachondromatosis	METCDS MC
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gingival Hypertrophy	Hypertrophy Of Gingivae
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic-Myeloproliferative Diseases Myelodysplastic/Myeloproliferative Disease Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Atrial Heart Septal Defect	Atrial Septal Defect Atrial Septal Defects Atrioseptal Defect Auricular Septal Defect Congenital Atrial Septal Defect Interatrial Septal Defect Interauricular Septal Defect Heart Septal Defects, Atrial Septal Defect, Atrial
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Heart Septal Defect	Septal Defect Heart Septal Defects Cardiac Septal Defects Congenital Septal Defect Of Heart
Rhabdomyosarcoma
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Schimmelpenning-Feuerstein-Mims Syndrome	Nevus Sebaceus Of Jadassohn Organoid Nevus Phakomatosis Linear Nevus Sebaceous Syndrome Sfm Syndrome Jadassohn Nevus Phakomatosis Jnp Schimmelpenning Syndrome Solomon Syndrome SFM Linear Sebaceous Nevus Syndrome Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic Nevus Sebaceus Syndrome Organoid Nevus Syndrome Schimmelpenning Feuerstein Mims Syndrome Sebaceous Nevus Syndrome, Linear Epidermal Nevus Syndrome, Formerly Sebaceous Nevus Syndrome Linear Linear Nevus Sebaceus Syndrome Epidermal Nevus Syndrome Ss Nevus Sebaceous
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Patent Ductus Arteriosus 1	Patent Ductus Arteriosus PDA1 Pda Ductus Arteriosus, Patent Patent Ductus Arteriosus, Susceptibility To Patent Ductus Botalli Patency Of The Ductus Arteriosus Patent Ductus Arteriosus Familial Ductus Arteriosus Patent Patent Ductus Arteriosus - Persisting Type
Polyhydramnios
Disorder Of Sexual Development	Disorder Of Sex Development Disorders Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Sex Differentiation Disorders
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Chromosome 1p36 Deletion Syndrome	1p36 Deletion Syndrome Deletion 1p36 Monosomy 1p36 Subtelomeric 1p36 Deletion Monosomy 1p36 Syndrome Distal Monosomy 1p36 Del(1)(P36) Deletion 1pter Monosomy 1pter
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-159127	HRS-4642		99.74%	Phase 2
HY-145926	MRTX0902	Inhibitor	99.67%	Phase 2
HY-134813	MRTX1133	Inhibitor	99.97%	Phase 1

Pre-clinical Phase

Bioactive Molecules (96)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125817	BI-3406	Inhibitor	99.95%	Unkown
HY-114398	BAY-293	Inhibitor	98.97%	Unkown
HY-134885	RMC-0331	Inhibitor	98.96%	Unkown
HY-111671	VUBI1		98.21%	Unkown
HY-161233A	BTX-6654 formate		98.85%	Unkown
HY-153606	VUBI1 analogue-1		98.94%	Unkown
HY-P2265A	SAH-SOS1A TFA	Inhibitor	96.55%	Unkown
HY-W056267	3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde		98.0%	Unkown
HY-151517	SOS1-IN-14	Inhibitor	99.60%	Unkown
HY-161235	BTX-7312		98.35%	Unkown
HY-163939	RGT-018	Inhibitor	99.77%	Unkown
HY-144962	SOS1-IN-11	Inhibitor	98.22%	Unkown
HY-145737A	PROTAC SOS1 degrader-1 TFA		98.38%	Unkown
HY-W115490	4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid		98.28%	Unkown
HY-151881	SOS1-IN-15	Inhibitor	98.04%	Unkown
HY-134813A	MRTX1133 formic	Inhibitor	98.23%	Unkown
HY-101796	NSC-70220	Inhibitor	99.42%	Unkown
HY-161233	BTX-6654		/	Unkown
HY-114398A	(S)-BAY-293		97.8%	Unkown
HY-144657A	(4S)-PROTAC SOS1 degrader-1 diTFA	Inhibitor	98.09%	Unkown
HY-148278	BI-0474	Inhibitor	99.83%	Unkown
HY-158310	SOS1/EGFR-IN-1	Inhibitor	99.54%	Unkown
HY-RS13576	SOS1 Human Pre-designed siRNA Set A		/	Unkown
HY-144212	SOS1-IN-8	Inhibitor	/	Unkown
HY-122685	UC-773587	Inhibitor	/	Unkown
HY-124514	UC-857993	Inhibitor	/	Unkown
HY-124755	RAS activator compound 1	Activator	98.90%	Unkown
HY-132129	SOS1-IN-2	Inhibitor	/	Unkown
HY-144207	SOS1-IN-9	Inhibitor	/	Unkown
HY-144210	SOS1-IN-6	Inhibitor	/	Unkown
HY-144211	SOS1-IN-7	Inhibitor	/	Unkown
HY-144213	SOS1-IN-10	Inhibitor	/	Unkown
HY-144657	(4S)-PROTAC SOS1 degrader-1		/	Unkown
HY-144965	SOS1-IN-12	Inhibitor	/	Unkown
HY-144967	SOS1-IN-13	Inhibitor	/	Unkown
HY-145046	SOS1-IN-3	Inhibitor	/	Unkown
HY-145047	SOS1-IN-4	Inhibitor	/	Unkown
HY-145048	SOS1-IN-5	Inhibitor	/	Unkown
HY-145737	PROTAC SOS1 degrader-1		/	Unkown
HY-148261	KRAS G12C inhibitor 56	Inhibitor	/	Unkown
HY-151968	KRAS G12C inhibitor 57	Inhibitor	/	Unkown
HY-152145	PROTAC SOS1 degrader-3		/	Unkown
HY-153674	PROTAC SOS1 degrader-4		/	Unkown
HY-153940	SOS1/KRAS-IN-1	Inhibitor	/	Unkown
HY-153989	SOS1-IN-16	Inhibitor	/	Unkown
HY-161173	PROTAC SOS1 degrader-5		/	Unkown
HY-161236	KRAS ligand 4	Inhibitor	/	Unkown
HY-161450	LHF418	Inhibitor	/	Unkown
HY-161452	SOS1 Ligand intermediate-3	Inhibitor	/	Unkown
HY-161634	PROTAC SOS1 degrader-8		/	Unkown
HY-161635	SOS1 Ligand intermediate-4	Inhibitor	/	Unkown
HY-161636	PROTAC SOS1 degrader-9		/	Unkown
HY-161637	E3 ligase Ligand 25		/	Unkown
HY-161639	E3 ligase Ligand 26		/	Unkown
HY-161654	PROTAC SOS1 degrader-10		/	Unkown
HY-161714	HH0043	Inhibitor	/	Unkown
HY-162281	PROTAC SOS1 degrader-6		/	Unkown
HY-163582	PROTAC SOS1 degrader-7		/	Unkown
HY-167768	SOS1 activator 2		/	Unkown
HY-168514	SOS1/EGFR-IN-2	Inhibitor	/	Unkown
HY-168637	SIAIS562055		/	Unkown
HY-168638	PROTAC SOS1 ligand 1	Inhibitor	/	Unkown
HY-168716	SOS1-IN-17	Inhibitor	/	Unkown
HY-169371	SOS1 Ligand intermediate-7	Inhibitor	/	Unkown
HY-172221	SOS1-IN-18	Inhibitor	/	Unkown
HY-173047	KRASG12C IN-15	Inhibitor	/	Unkown
HY-173341	SOF-436	Inhibitor	/	Unkown
HY-175244	SOS1-IN-20	Inhibitor	/	Unkown
HY-175326	SOS1-IN-21	Inhibitor	/	Unkown
HY-175560	SOS1-IN-22	Inhibitor	/	Unkown
HY-175575	SOS1 ligand-2	Ligand	/	Unkown
HY-175891	POI ligand-5		/	Unkown
HY-176170	SOS1-IN-19	Inhibitor	/	Unkown
HY-176789	VUBI1-octanoic acid	Inhibitor	/	Unkown
HY-178044	SOS1-IN-24	Inhibitor	/	Unkown
HY-179414	KRAS G12D-IN-34	Inhibitor	/	Unkown
HY-179443	SOS1-IN-25	Inhibitor	/	Unkown
HY-181807	SOS1/KRAS-IN-2		/	Unkown
HY-182411	KRAS-IN-56	Inhibitor	/	Unkown
HY-183365	SL43	Inhibitor	/	Unkown
HY-184422	SOS1-IN-26		/	Unkown
HY-184423	SOS1-IN-27		/	Unkown
HY-184586	SOS1-IN-28	Inhibitor	/	Unkown
HY-184855	(S,S,S,S)-AHPC-Me		/	Unkown
HY-19539	NSC-658497	Inhibitor	/	Unkown
HY-P2265	SAH-SOS1A	Inhibitor	/	Unkown
HY-112078B	(S,S,S)-AHPC-Me		/	Unkown
HY-161638	E3 Ligase Ligand-linker Conjugate 108		/	Unkown
HY-161640	E3 Ligase Ligand-linker Conjugate 109		/	Unkown
HY-161655	SOS1 Ligand intermediate-5	Inhibitor	/	Unkown
HY-161656	PIP-C-3-Azaspiro[5.5]undecane-boc		/	Unkown
HY-161657	2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP		/	Unkown
HY-163583	SOS1 Ligand intermediate-6	Inhibitor	/	Unkown
HY-RS16568	Sos1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS23001	Sos1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS26460	Sos2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SOS1	MGD	MGI:98354
Felis catus	SOS1	VGNC	VGNC:65576
Rattus norvegicus	SOS1	RGD	RGD:1310949
Canis familiaris	SOS1	VGNC	VGNC:46665
Macaca mulatta	SOS1	VGNC	VGNC:77837
Bos taurus	SOS1	VGNC	VGNC:35134
Others	SOS1	NCBI