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SOS1-IN-17

SOS1-IN-17 (Compound 8d) is an orally active inhibitor for SOS1-KRASG12C interaction with an IC50 of 5.1 nM. SOS1-IN-17 inhibits ERK phosphorylation in DLD-1 cell with an IC50 of 18 nM. SOS1-IN-17 exhibits anti-proliferative activity in KRASG12C mutated Mia-Paca-2 cell with an IC50 of 0.11 μM. SOS1-IN-17 exhibits antitumor efficacy against pancreatic cancer in mouse model.

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  • 分子式: C29H34F3N5O2
  • 分子量:541.61
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • SOS1-IN-17 Chemical Structure
    SOS1-IN-17 構造式
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  • SOS1-IN-17 Chemical Structure
    SOS1-IN-17 Chemical Structure
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  • SOS1-IN-17