2. GPCR/G Protein
  3. Ras
  4. BAY-293

BAY-293 

Cat. No.: HY-114398 Purity: 98.06%
COA Handling Instructions

BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS.

For research use only. We do not sell to patients.

BAY-293 Chemical Structure

BAY-293 Chemical Structure

CAS No. : 2244904-70-7

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10 mM * 1 mL in DMSO USD 253 In-stock
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10 mM * 1 mL
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 USD 253 In-stock
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50 mg USD 1660 In-stock
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Based on 1 publication(s) in Google Scholar

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K-Ras H-Ras Ras

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Description

BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS[1].

IC50 & Target[1]

KRAS-SOS1

21 nM (IC50)

In Vitro

BAY-293 inhibits the activation of RAS in HeLa cells, with IC50 values in the submicromolar range[1].
BAY-293 (595 nM-3580 nM; 72 hours) shows efficient antiproliferative activity against wild-type KRAS cell lines (K-562, MOLM-13) and cell lines with KRASG12C mutation (NCI-H358, Calu-1)[1].
BAY-293 efficiently inhibits pERK levels in K-562 cells after incubation for 60 min without affecting total protein levels of ERK[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: K-562, MOLM-13, H358 and Calu-1 cell lines
Concentration: 595-3580 nM
Incubation Time: 72 hours
Result: IC50s of 1,090±170 nM, 995±400 nM, 3,480±100 nM and 3,190±50 nM for K-562, MOLM-13, H358 and Calu-1 cells, respectively.
Molecular Weight

448.58

Appearance

Solid

Formula

C25H28N4O2S
CAS No.
SMILES

COC1=C(OC)C=C(N=C(C)N=C2N[[email protected]](C)C3=CC(C4=C(CNC)C=CC=C4)=CS3)C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (278.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2293 mL 11.1463 mL 22.2926 mL
5 mM 0.4459 mL 2.2293 mL 4.4585 mL
10 mM 0.2229 mL 1.1146 mL 2.2293 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

BAY-2932244904-70-7BAY293BAY 293RasInhibitorinhibitorinhibit

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