HCK - HCK proto-oncogene, Src family tyrosine kinase Gene

Also Known as JTK9; p59Hck; p61Hck

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3055

About HCK

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,052,242-32,101,856 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 32 paralogues. Broad expression in appendix (RPKM 55.1), spleen (RPKM 40.9) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

HCK Products (6)

mRNA	Protein	Name
NM_001172129.3	NP_001165600.1	tyrosine-protein kinase HCK isoform b
NM_001172130.3	NP_001165601.1	tyrosine-protein kinase HCK isoform c
NM_001172131.3	NP_001165602.1	tyrosine-protein kinase HCK isoform d
NM_001172132.3	NP_001165603.1	tyrosine-protein kinase HCK isoform e
NM_001172133.3	NP_001165604.1	tyrosine-protein kinase HCK isoform b
NM_002110.5	NP_002101.2	tyrosine-protein kinase HCK isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipid binding	EXP EXP: Inferred from Experiment	31877324	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7859737	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	10861086	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	10092522	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	11904303	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17535448	GOA
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17535448	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11904303	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	11904303	GOA
involved in regulation of podosome assembly	IDA IDA: Inferred from direct assay	15998323	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	15998323	GOA
located in caveola	IDA IDA: Inferred from direct assay	7791757	GOA
located in cytoplasmic side of plasma membrane	IMP IMP: Inferred from mutant phenotype	11904303	GOA
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	11904303	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15998323	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
506 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase HCK	hematopoietic cell kinase

HCK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HCK	P08631	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	HCK	P08631	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	HCK	P08631	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	HCK	P08631	PAK2	Homo sapiens	Q13177	Phage Display	16374509
Intra	HCK	P08631	KHDRBS1	Homo sapiens	Q07666	Y2H	22641034
Intra	HCK	P08631	KHDRBS1	Homo sapiens	Q07666	Fluorescence Spectr	17141806
Intra	HCK	P08631	KIT	Homo sapiens	P10721	FPS	24728074
Intra	HCK	P08631	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	HCK	P08631	EGFR	Homo sapiens	P00533	PLA	23397142
Intra	HCK	P08631	SOS1	Homo sapiens	Q07889	PLA	23397142
Intra	HCK	P08631	PDCD6IP	Homo sapiens	Q8WUM4	Pull Down	22641034
Intra	HCK	P08631	WAS	Homo sapiens	P42768	Far-WB	19234535
Intra	HCK	P08631	WAS	Homo sapiens	P42768	Anti Bait CoIP	19234535
Intra	HCK	P08631	WAS	Homo sapiens	P42768	Pull Down	19234535
Intra	HCK	P08631	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	HCK	P08631	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	HCK	P08631	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	HCK	P08631	NLRP12	Homo sapiens	P59046	Anti Bait CoIP	32226298
Intra	HCK	P08631	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	HCK	P08631	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	HCK	P08631	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Cross	HCK	P08631	nef	Human immunodeficiency virus	Q90VU7	Phage Display	16374509
Intra	HCK	P08631	ADAM15	Homo sapiens	Q13444	Pull Down	11741929
Intra	HCK	P08631	ALOX5	Homo sapiens	P09917	Protein Kinase Assay	24860872
Intra	HCK	P08631	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	HCK	P08631	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Cross	HCK	P08631	nef	Human immunodeficiency virus	P03406	Pull Down	18042718
Cross	HCK	P08631	nef	Human immunodeficiency virus	P03406	Y2H	18042718
Cross	HCK	P08631	polg_hcv77	Hepatitis C virus	P27958	ELISA	15784897
Cross	HCK	P08631	polg_hcv77	Hepatitis C virus	P27958	Pull Down	14993658
Cross	HCK	P08631	polg_hcv77	Hepatitis C virus	P27958	Pull Down	15784897
Cross	HCK	P08631	polg_hcvj4	Hepatitis C virus	O92972	Pull Down	14993658
Cross	HCK	P08631	polg_hcvj4	Hepatitis C virus	O92972	ELISA	15784897
Cross	HCK	P08631	vif	Human immunodeficiency virus	P12504	Pull Down	11278465

Cross: Cross-species interaction Intra: Intraspecies interaction

HCK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83218	Hck Antibody (YA2963)	WB, ICC/IF	Human
HY-P83218A	Hck Antibody (YA2963)(PBS only)	WB, ICC/IF, IP	Human
HY-P85197	Hck Antibody (YA4889)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Renal Pelvis Adenocarcinoma	Adenocarcinoma Of Renal Pelvis Adenocarcinoma Of The Kidney Pelvis
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Cd45 Deficiency
Lung Clear Cell Carcinoma
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175451	MRT-10350	Degrader	99.10%	Unkown
HY-181050	DFCI-002-06	Degrader	/	Unkown
HY-178950	Hck-IN-3	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-175437	MRT-7612	Degrader	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HCK	VGNC	VGNC:29774
Rattus norvegicus	HCK	RGD	RGD:2785
Canis familiaris	HCK	VGNC	VGNC:41618
Mus musculus	HCK	MGD	MGI:96052
Felis catus	HCK	VGNC	VGNC:67542
Macaca mulatta	HCK	VGNC	VGNC:73353
Others	HCK	NCBI