SIK1-IN-1
SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC50 of 0.7 nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 μM). SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN).
For research use only. We do not sell to patients.
- Formula: C21H20ClN5O2
- Molecular Weight:409.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SIK1 0.7 nM (IC50) |
SIK2 75.3 nM (IC50) |
SIK3 240 nM (IC50) |
Lyn <1.5 nM (IC50) |
Hck <3 nM (IC50) |
Fgr <3 nM (IC50) |
Yes <3 nM (IC50) |
Lck 3.7 nM (IC50) |
Chemical Information
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Molecular Weight 409.87
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Formula C21H20ClN5O2
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SMILES
COC1=CN2C(C(NC3=C(C=C(C=C3C)Cl)C)=O)=CN=C2C=C1C4=NN(C=C4)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIK1-IN-1 Related Classifications
HY-178014 Related Classifications
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