Hck-IN-3
Hck-IN-3 (compound 2D) is an orally effective inhibitor targeting HCK (KD = 3.92 μM). Hck-IN-3 can inhibit the release of NO. Hck-IN-3 has an IC50 of 6.52 μM in RAW264.7 cells. Hck-IN-3 can inhibit the release of TNF-α, IL-6, and IL-1β in a concentration dependent manner. Hck-IN-3 downregulates the protein expression of NLRP3, ASC, pro-caspase-1, and pro-IL-1β in a concentration dependent manner. Hck-IN-3 can be used for research on acute non traumatic inflammatory conditions.
For research use only. We do not sell to patients.
- CAS No.: 3115216-60-6
- Formula: C32H35BrN2O6
- Molecular Weight:623.53
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Caspase Isoforms
More
Biological Activity
|
IL-6 |
IL-1β |
Caspase-1 |
Hck |
NLRP3 |
Chemical Information
-
CAS No. 3115216-60-6
-
Molecular Weight 623.53
-
Formula C32H35BrN2O6
-
SMILES
COC1=C(OC)C=C(C2=CC(C=CC(OC)=C3OCC4=CC=C(NC(OC(C)(C)C)=O)C=C4)=C3C=[N+]2CC5)C5=C1.[Br-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz