2. Protein Tyrosine Kinase/RTK Apoptosis Immunology/Inflammation
  3. Src TNF Receptor Interleukin Related NOD-like Receptor (NLR) Caspase
  4. Hck-IN-3

Hck-IN-3 (compound 2D) is an orally effective inhibitor targeting HCK (KD = 3.92 μM). Hck-IN-3 can inhibit the release of NO. Hck-IN-3 has an IC50 of 6.52 μM in RAW264.7 cells. Hck-IN-3 can inhibit the release of TNF-α, IL-6, and IL-1β in a concentration dependent manner. Hck-IN-3 downregulates the protein expression of NLRP3, ASC, pro-caspase-1, and pro-IL-1β in a concentration dependent manner. Hck-IN-3 can be used for research on acute non traumatic inflammatory conditions.

For research use only. We do not sell to patients.

Hck-IN-3

Hck-IN-3 Chemical Structure

CAS No. : 3115216-60-6

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Hck-IN-3 Related Antibodies

Top Publications Citing Use of Products

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

View All NOD-like Receptor (NLR) Isoform Specific Products:

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NLRP3 NLRP1 NOD1 NOD2

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Hck-IN-3 (compound 2D) is an orally effective inhibitor targeting HCK (KD = 3.92 μM). Hck-IN-3 can inhibit the release of NO. Hck-IN-3 has an IC50 of 6.52 μM in RAW264.7 cells. Hck-IN-3 can inhibit the release of TNF-α, IL-6, and IL-1β in a concentration dependent manner. Hck-IN-3 downregulates the protein expression of NLRP3, ASC, pro-caspase-1, and pro-IL-1β in a concentration dependent manner. Hck-IN-3 can be used for research on acute non traumatic inflammatory conditions[1].

IC50 & Target[1]

IL-6

 

IL-1β

 

Caspase-1

 

Hck

 

NLRP3

 

Molecular Weight

623.53

Formula

C32H35BrN2O6
CAS No.
SMILES

COC1=C(OC)C=C(C2=CC(C=CC(OC)=C3OCC4=CC=C(NC(OC(C)(C)C)=O)C=C4)=C3C=[N+]2CC5)C5=C1.[Br-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hck-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hck-IN-33115216-60-6SrcTNF ReceptorInterleukin RelatedNOD-like Receptor (NLR)CaspaseTumor Necrosis Factor ReceptorTNFRILHCKNOTNF-αIL-6IL-1βNLRP3ASCpro-caspase-1inflammatoryInhibitorinhibitorinhibit

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