PP124
PP124 is a multi-kinase inhibitor. PP124 inhibits the phosphoinositide 3-kinase (PI3K) catalytic isoforms p110α, p110β, p110δ, and p110γ (IC50 = 4 μM, 7 μM, 0.966 μM, and 1.5 μM), mTOR and DNAPK (IC50 = 0.493 μM and 0.054 μM), as well as the tyrosine kinases Abl, Hck, Src, mutant Src (T/I), VEGFR, EGFR, and EphB4 (IC50 = 0.165 μM, 0.005 μM, 0.017 μM, 0.25 μM, 0.134 μM, 0.085 μM, and 0.17 μM). PP124 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1092788-95-8
- Formula: C18H18N6
- Molecular Weight:318.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
p110α 4 μM (IC50) |
p110β 7 μM (IC50) |
p110δ 0.966 μM (IC50) |
p110γ 1.5 μM (IC50) |
EPHB4 0.17 μM (IC50) |
Abl 0.165 μM (IC50) |
Hck 0.005 μM (IC50) |
In Vitro
Effective research across multiple cancers requires simultaneous inhibition of multiple oncogenic kinases. The reason is that tumor cells rapidly develop resistance to single-kinase inhibitors.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1092788-95-8
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Molecular Weight 318.38
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Formula C18H18N6
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SMILES
N=1C=NC2=C(C1N)C(=NN2C3CCCC3)C=4C=CC=5C=CNC5C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PP124 Related Classifications
HY-134468 Related Classifications
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