PP162
PP162 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 of 53 nM. PP162 selectively inhibits DNA-PK by binding to a conserved hydrophobic pocket. PP162 exhibits weak inhibitory activity against various tyrosine kinases and PI3K family members. PP162 can be used for research on selective kinase targeting.
For research use only. We do not sell to patients.
- CAS No.: 1092788-97-0
- Formula: C17H17N7
- Molecular Weight:319.36
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
p110α 6.3 μM (IC50) |
p110β 15 μM (IC50) |
p110δ 2.3 μM (IC50) |
p110γ 2.4 μM (IC50) |
Abl 13 μM (IC50) |
Hck 8.9 μM (IC50) |
In Vitro
PP162 selectively inhibits purified DNA-PK with an IC50 of 53 nM, and in cell-free kinase assays it also inhibits purified p110α, p110β, p110δ, p110γ, mTOR, Abl, Hck, and Src with IC50 values of 6.3 µM, 15 µM, 2.3 µM, 2.4 µM, 4.8 µM, 13 µM, 8.9 µM, and 11 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 1092788-97-0
-
Molecular Weight 319.36
-
Formula C17H17N7
-
SMILES
NC1=C2C(N(C3CCCC3)N=C2C4=CC5=NC=CN5C=C4)=NC=N1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PP162 Related Classifications
HY-134469 Related Classifications
Powered by Bioz