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PAK2 - p21 (RAC1) activated kinase 2 Gene

Also Known as KNO2; PAK65; PAKgamma

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5062

About PAK2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,739,857-196,832,647 (from NCBI)

This gene has 3 transcripts (splice variants), 293 orthologues and 35 paralogues. Ubiquitous expression in spleen (RPKM 22.2), appendix (RPKM 21.0) and 25 other tissues.

Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to Cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated Apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

PAK2 Products (4)

mRNA	Protein	Name
XM_047448219.1	XP_047304175.1	serine/threonine-protein kinase PAK 2 isoform X1
XM_011512870.3	XP_011511172.1	serine/threonine-protein kinase PAK 2 isoform X1
NM_002577.4	NP_002568.2	serine/threonine-protein kinase PAK 2
XM_047448218.1	XP_047304174.1	serine/threonine-protein kinase PAK 2 isoform X1

PAK2 Protein Structure

PBD

Pkinase

0
100
200
300
400
500
524 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PAK 2	PAK-2 S6/H4 kinase gamma-PAK p21 (CDKN1A)-activated kinase 2 p21 protein (Cdc42/Rac)-activated kinase 2 p21-activated kinase 2 p58

PAK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Pull Down	32707033
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Pull Down	22705156
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Y2H Prey Pooling	25416956
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Pull Down	19264842
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Validated Y2H	32296183
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Pull Down	32707033
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Solid Phase Assay	20696164
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Anti Bait CoIP	17353931
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Y2H Array	32296183
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Filter Binding	16374509
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Anti Tag CoIP	35271311
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Y2H Array	32296183
Intra	PAK2	Q13177	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PAK2	Q13177	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	PAK2	Q13177	HCK	Homo sapiens	P08631	Filter Binding	16374509
Intra	PAK2	Q13177	NCK1	Homo sapiens	P16333	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	NCK1	Homo sapiens	P16333	Y2H Array	32296183
Intra	PAK2	Q13177	SORBS1	Homo sapiens	Q9BX66	Filter Binding	16374509
Intra	PAK2	Q13177	LIMK1	Homo sapiens	P53667	Protein Kinase Assay	16837009
Intra	PAK2	Q13177	HTT	Homo sapiens	P42858	Anti Tag CoIP	19240112
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Protein Kinase Assay	21555521
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Anti Bait CoIP	21555521
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Confocal	21555521
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Anti Tag CoIP	21555521
Intra	PAK2	Q13177	RHOJ	Homo sapiens	Q9H4E5	Validated Y2H	32296183
Intra	PAK2	Q13177	RHOJ	Homo sapiens	Q9H4E5	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	RHOJ	Homo sapiens	Q9H4E5	Y2H Array	32296183
Intra	PAK2	Q13177	NCK2	Homo sapiens	O43639	Anti Tag CoIP	35271311
Intra	PAK2	Q13177	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	NCK2	Homo sapiens	O43639	Y2H Array	32296183
Intra	PAK2	Q13177	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	16787945
Intra	PAK2	Q13177	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	35271311
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Filter Binding	16374509
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	25416956
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Validated Y2H	25416956
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Y2H Array	25416956
Cross	PAK2	Q13177	Arhgef7	Rattus norvegicus	O55043	ITC	16527308

Cross: Cross-species interaction Intra: Intraspecies interaction

PAK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80778	PAK2 Antibody (YA695)	WB, IHC-F, IHC-P, ICC/IF	Human, Monkey
HY-P80778A	PAK2 Antibody (YA695)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Monkey
HY-P85312	PAK2 Antibody (YA5004)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Knobloch Syndrome 2	KNO2 Knobloch Syndrome, Type 2
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Knobloch Syndrome 1	Retinal Detachment And Occipital Encephalocele Knobloch Syndrome, Type 1 KNO1 Kno Knobloch Syndrome
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Glucosephosphate Dehydrogenase Deficiency	G6pd Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency Deficiency Of Glucose-6-Phosphate Dehydrogenase Glucose 6 Phosphate Dehydrogenase Deficiency Deficiency Of G-6pd G6pdd
Knobloch Syndrome	Knobloch-Layer Syndrome Retinal Detachment-Occipital Encephalocele Syndrome Myopia Retinal Detachment Encephalocele Retinal Detachment And Occipital Encephalocele

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13007	PF-3758309	Inhibitor	99.79%	Phase 1
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Phase 1
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15542A	FRAX597	Inhibitor	99.36%	Unkown
HY-15542B	FRAX486	Inhibitor	98.10%	Unkown
HY-19635	G-5555	Inhibitor	99.88%	Unkown
HY-19538	FRAX1036	Inhibitor	98.88%	Unkown
HY-120940	AZ13705339	Inhibitor	98.57%	Unkown
HY-19635A	G-5555 hydrochloride	Inhibitor	98.26%	Unkown
HY-171034	PQA-18	Inhibitor	99.62%	Unkown
HY-131043	NVS-PAK1-C	Inhibitor	99.2%	Unkown
HY-120940A	AZ13705339 hemihydrate	Inhibitor	99.77%	Unkown
HY-146786	ZMF-10	Inhibitor	/	Unkown
HY-184447	RN193	Inhibitor	/	Unkown
HY-182357	PAK1-IN-3	Inhibitor	/	Unkown
HY-116917	G-9791	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PAK2	MGD	MGI:1339984
Bos taurus	PAK2	VGNC	VGNC:53593
Macaca mulatta	PAK2	VGNC	VGNC:84053
Canis familiaris	PAK2	VGNC	VGNC:53081
Felis catus	PAK2	VGNC	VGNC:102796
Rattus norvegicus	PAK2	RGD	RGD:61953
Others	PAK2	NCBI