PAK2 - p21 (RAC1) activated kinase 2 Gene

Homo sapiens

Also known as KNO2; PAK65; PAKgamma

Gene ID: 5062 | Gene type: protein coding

About PAK2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,739,857-196,832,647 (from NCBI)

This gene has 3 transcripts (splice variants), 293 orthologues and 35 paralogues. Ubiquitous expression in spleen (RPKM 22.2), appendix (RPKM 21.0) and 25 other tissues.

Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to Cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated Apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

PAK2 Products(4)

mRNA	Protein	Name
XM_047448219.1	XP_047304175.1	serine/threonine-protein kinase PAK 2 isoform X1
XM_011512870.3	XP_011511172.1	serine/threonine-protein kinase PAK 2 isoform X1
NM_002577.4	NP_002568.2	serine/threonine-protein kinase PAK 2
XM_047448218.1	XP_047304174.1	serine/threonine-protein kinase PAK 2 isoform X1

PAK2 Protein Structure

PBD

Pkinase

0
100
200
300
400
524 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 2

PAK-2	S6/H4 kinase
gamma-PAK	p21 (CDKN1A)-activated kinase 2
p21 protein (Cdc42/Rac)-activated kinase 2	p21-activated kinase 2
p58

Related Diseases

Diseases

Alias

Knobloch Syndrome 2

KNO2	Knobloch Syndrome, Type 2

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Knobloch Syndrome 1

Retinal Detachment And Occipital Encephalocele	Knobloch Syndrome, Type 1
KNO1	Kno
Knobloch Syndrome

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency	Glucose-6-Phosphate Dehydrogenase Deficiency
Deficiency Of Glucose-6-Phosphate Dehydrogenase	Glucose 6 Phosphate Dehydrogenase Deficiency
Deficiency Of G-6pd	G6pdd

Knobloch Syndrome

Knobloch-Layer Syndrome	Retinal Detachment-Occipital Encephalocele Syndrome
Myopia Retinal Detachment Encephalocele	Retinal Detachment And Occipital Encephalocele

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15542A	FRAX597	Inhibitor	99.79%	Unkown
HY-15542B	FRAX486	Inhibitor	98.01%	Unkown
HY-19635	G-5555	Inhibitor	99.29%	Unkown
HY-19538	FRAX1036	Inhibitor	98.88%	Unkown
HY-19635A	G-5555 hydrochloride	Inhibitor	98.78%	Unkown
HY-120940	AZ13705339	Inhibitor	98.90%	Unkown
HY-120940A	AZ13705339 hemihydrate	Inhibitor	99.77%	Unkown
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Unkown
HY-116917	G-9791	Inhibitor	/	Unkown
HY-146786	ZMF-10	Inhibitor	/	Unkown
HY-131043	NVS-PAK1-C	Inhibitor	≥99.0%	Unkown
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PAK2	MGD	MGI:1339984
Bos taurus	PAK2	VGNC	VGNC:53593
Macaca mulatta	PAK2	VGNC	VGNC:84053
Canis familiaris	PAK2	VGNC	VGNC:53081
Felis catus	PAK2	VGNC	VGNC:102796
Rattus norvegicus	PAK2	RGD	RGD:61953
Others	PAK2	NCBI

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