1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. PAK
  3. NVS-PAK1-C

NVS-PAK1-C 

Cat. No.: HY-131043
Handling Instructions

NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM).

For research use only. We do not sell to patients.

NVS-PAK1-C Chemical Structure

NVS-PAK1-C Chemical Structure

CAS No. : 2250019-95-3

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Description

NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1].

IC50 & Target[1]

PAK1

0.007 μM (Kd)

PAK2

0.4 μM (Kd)

PAK1

5 nM (IC50)

PAK2

270 nM (IC50)

In Vitro

NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated[1].

Molecular Weight

465.90

Formula

C₂₂H₂₃ClF₃N₅O

CAS No.

2250019-95-3

SMILES

O=C(N1C[[email protected]@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C4=CC=C(Cl)C=C42)CC1)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NVS-PAK1-CPAKp21 activated kinasesPAK1Su86.86dephosphorylatedphosphorylatedprobeATP-competitiveInhibitorinhibitorinhibit

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NVS-PAK1-C
Cat. No.:
HY-131043
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