2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. PAK
  5. PAK1 Isoform

PAK1

 
Cat. No. Product Name Effect Purity
  • HY-12005
    Fingolimod hydrochloride
    		Activator 99.95%
    Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator.
  • HY-15027
    5-Aminosalicylic Acid
    		Inhibitor ≥98.0%
    5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
  • HY-11063
    Fingolimod
    		Activator 99.56%
    Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells.
  • HY-15542A
    FRAX597
    		Inhibitor 99.79%
    FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC50 of 8, 13 and 19 nM for PAK1, 2 and 3.
  • HY-13007
    PF-3758309
    		Inhibitor 99.84%
    PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM).
  • HY-120940A
    AZ13705339 hemihydrate
    		Inhibitor 99.77%
    AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively.
  • HY-15663
    IPA-3
    		Inhibitor 99.43%
    IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, and shows no inhibition to group II PAKs (PAKs 4-6).
  • HY-15542B
    FRAX486
    		Inhibitor 98.01%
    FRAX486 is a p21-activated kinase (PAK) inhibitor with IC50s of 14, 33 and 39 nM for PAK1, PAK2 and PAK3, respectively.
  • HY-19635
    G-5555
    		Inhibitor 99.29%
    G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.
  • HY-19538
    FRAX1036
    		Inhibitor 98.88%
    FRAX1036 is a PAK inhibitor with Kis of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.
  • HY-19635A
    G-5555 hydrochloride
    		Inhibitor 98.78%
    G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
  • HY-120940
    AZ13705339
    		Inhibitor 98.90%
    AZ13705339 is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively.
  • HY-146681
    PAK1-IN-1
    		Inhibitor
    PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM.
  • HY-13007A
    PF-3758309 hydrochloride
    		Inhibitor
    PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM).
  • HY-13007B
    PF-3758309 dihydrochloride
    		Inhibitor
    PF-3758309 (PF-03758309) dihydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM).
  • HY-131043
    NVS-PAK1-C
    		Inhibitor
    NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively.
  • HY-131265
    Mesalamine impurity P
    		Inhibitor
    Mesalamine impurity P is an impurity of Mesalamine (HY-15027).
  • HY-146783
    ZINC194100678
    		Inhibitor
    ZINC194100678 is a potent PAK1 inhibitor with an IC50 value of 8.37 μM.
  • HY-146786
    ZMF-10
    		Inhibitor
    ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively.
Cat. No. Product Name / Synonyms Species Source