2. Immunology/Inflammation Cytoskeleton Cell Cycle/DNA Damage
  3. Salt-inducible Kinase (SIK) PAK
  4. SIK2/3-IN-2

SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer.

For research use only. We do not sell to patients.

SIK2/3-IN-2

SIK2/3-IN-2 Chemical Structure

CAS No. : 1648864-21-4

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SIK2/3-IN-2 Related Antibodies

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SIK1 SIK2 SIK3

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PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

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Description

SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer[1][2].

IC50 & Target[1][2]

PAK1

20.7 nM (Ki)

SIK2

65 nM (IC50)

SIK3

14 nM (IC50)

Molecular Weight

492.96

Formula

C25H25ClN6O3
CAS No.
SMILES

O=C(N(C1=N2)C[C@H]3OC[C@@H](CO3)N)C(C4=C(C=C(C5=C(C=CC=N5)C)C=C4)Cl)=CC1=CN=C2NC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SIK2/3-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIK2/3-IN-21648864-21-4Salt-inducible Kinase (SIK)PAKp21 activated kinasesp21-activated protein kinasehyperproliferative diseasesPaclitaxel-resistant ovarian cancerInhibitorinhibitorinhibit

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