SIK2/3-IN-2
SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer.
For research use only. We do not sell to patients.
- CAS No.: 1648864-21-4
- Formula: C25H25ClN6O3
- Molecular Weight:492.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PAK1 20.7 nM (Ki) |
SIK2 65 nM (IC50) |
SIK3 14 nM (IC50) |
Chemical Information
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CAS No. 1648864-21-4
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Molecular Weight 492.96
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Formula C25H25ClN6O3
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SMILES
O=C(N(C1=N2)C[C@H]3OC[C@@H](CO3)N)C(C4=C(C=C(C5=C(C=CC=N5)C)C=C4)Cl)=CC1=CN=C2NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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