1648864-21-4
Chemical Structure
SIK2/3-IN-2
- CAS No.: 1648864-21-4
- Formula:C25H25ClN6O3
- Molecular Weight:492.96
IUPAC Name: 8-(((2r,5r)-5-amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(3-methylpyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
InChIKey: JRCJXODVUXPOGA-CYWCHRQTSA-N
SMILES: O=C(N(C1=N2)C[C@H]3OC[C@@H](CO3)N)C(C4=C(C=C(C5=C(C=CC=N5)C)C=C4)Cl)=CC1=CN=C2NC
Biological Activity: SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer[1][2].
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SIK2/3-IN-2 | SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer. | |||||||||||||||||||||
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