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    Cytoskeleton
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  3. PAK1-IN-1

PAK1-IN-1 

Cat. No.: HY-146681
Handling Instructions

PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner.

For research use only. We do not sell to patients.

PAK1-IN-1 Chemical Structure

PAK1-IN-1 Chemical Structure

CAS No. : 2485732-30-5

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Description

PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

IC50 & Target[1]

PAK1

9.8 nM (IC50)

PAK4

>10 μM (IC50)

In Vitro

PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT-116 cells
Concentration: 1 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10, 20 µM
Incubation Time: 1, 24 h
Result: Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.
Molecular Weight

469.92

Formula

C26H20ClN5O2

CAS No.
SMILES

CC1=CC=CN(C1=O)C2=CC=C(C(Cl)=C2)C3=CC=C4C(NN=C4C(NCC5=CC=NC=C5)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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PAK1-IN-1
Cat. No.:
HY-146681
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