PAK1-IN-1
PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner.
For research use only. We do not sell to patients.
- CAS No.: 2485732-30-5
- Formula: C26H20ClN5O2
- Molecular Weight:469.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PAK1 9.8 nM (IC50) |
PAK4 >10 μM (IC50) |
In Vitro
PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:MDA-MB-231, HCT-116 cells
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Concentration:1 µM
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Incubation Time:72 h
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Result:Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively.
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Cell Line:MDA-MB-231 cells
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Concentration:2.5, 5, 10, 20 µM
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Incubation Time:1, 24 h
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Result:Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.
Chemical Information
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CAS No. 2485732-30-5
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Molecular Weight 469.92
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Formula C26H20ClN5O2
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SMILES
CC1=CC=CN(C1=O)C2=CC=C(C(Cl)=C2)C3=CC=C4C(NN=C4C(NCC5=CC=NC=C5)=O)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell migration
Cell migration is a method that plays an important role in wound healing, cell differentiation, embryonic development, etc.
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Cell invasion
Cell invasion is the ability of cells to migrate from one area to another via the extracellular matrix. Cell invasion is the response of normal and cancer cells to chemical and mechanical stimuli. Before migrating to a new region, the extracellular matrix is degraded by proteases within the cell. Cell invasion often occurs during wound repair, vascularization and inflammation, abnormal tissue invasion, and tumor cell metastasis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAK1-IN-1 Related Classifications
HY-146681 Related Classifications
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