162359-55-9
162359-55-9
Chemical Structure
Fingolimod
Synonym(s): FTY720 free base
- CAS No.: 162359-55-9
- Formula:C19H33NO2
- Molecular Weight:307.47
IUPAC Name: 2-amino-2-(4-octylphenethyl)propane-1,3-diol
InChIKey: KKGQTZUTZRNORY-UHFFFAOYSA-N
SMILES: OCC(CCC1=CC=C(CCCCCCCC)C=C1)(N)CO
Biological Activity: Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1][2][3][4][5].
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Fingolimod | 99.97% | Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. | ||||||||||||||||||||
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Fingolimod (Standard) | 99.97% | Fingolimod (Standard) is the analytical standard of Fingolimod. This product is intended for research and analytical applications. Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. | ||||||||||||||||||||
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Fingolimod-d4 | 99.11% | Fingolimod-d4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. | ||||||||||||||||||||
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References
- [1]. Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586. [Content Brief]
- [2]. Szepanowski F, et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. J Neuroinflammation. 2016 Jun 10;13(1):143. [Content Brief]
- [3]. Airas L, et al. In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. J Nucl Med. 2015 Feb;56(2):305-10. [Content Brief]
- [4]. Shirakabe K, et al. Modification of lymphocyte migration to Peyer's patches by inhibition of sphingosine-1-phosphate lyase ameliorates murine colitis. J Gastroenterol Hepatol. 2018 Jan 15. [Content Brief]
- [5]. Hunter S F, et al. The direct effects of fingolimod in the central nervous system: implications for relapsing multiple sclerosis[J]. CNS drugs, 2016, 30(2): 135-147.
