2. Cell Cycle/DNA Damage Cytoskeleton
  3. PAK
  4. AZ13705339

AZ13705339 is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 can be used in the research of cancers.

For research use only. We do not sell to patients.

AZ13705339 Chemical Structure

AZ13705339 Chemical Structure

CAS No. : 2016806-57-6

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Based on 1 publication(s) in Google Scholar

Other Forms of AZ13705339:

AZ13705339 Related Antibodies

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PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

AZ13705339 is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 can be used in the research of cancers[1].

IC50 & Target[1]

PAK2

0.32 nM (Kd)

PAK1

0.28 nM (Kd)

PAK1

0.33 nM (IC50)

pPAK1

59 nM (IC50)

In Vitro

AZ13705339 (1 μM) inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells[2].
AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZ13705339 Related Antibodies
In Vivo

AZ13705339 (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

629.75

Formula

C33H36FN7O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=CC=C1CN(C2=NC(NC3=CC=C(N4CCN(C)CC4)C(S(=O)(CC)=O)=C3)=NC=C2F)C5=CC(CO)=CC=C5C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (396.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5879 mL 7.9397 mL 15.8793 mL
5 mM 0.3176 mL 1.5879 mL 3.1759 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5879 mL 7.9397 mL 15.8793 mL 39.6983 mL
5 mM 0.3176 mL 1.5879 mL 3.1759 mL 7.9397 mL
10 mM 0.1588 mL 0.7940 mL 1.5879 mL 3.9698 mL
15 mM 0.1059 mL 0.5293 mL 1.0586 mL 2.6466 mL
20 mM 0.0794 mL 0.3970 mL 0.7940 mL 1.9849 mL
25 mM 0.0635 mL 0.3176 mL 0.6352 mL 1.5879 mL
30 mM 0.0529 mL 0.2647 mL 0.5293 mL 1.3233 mL
40 mM 0.0397 mL 0.1985 mL 0.3970 mL 0.9925 mL
50 mM 0.0318 mL 0.1588 mL 0.3176 mL 0.7940 mL
60 mM 0.0265 mL 0.1323 mL 0.2647 mL 0.6616 mL
80 mM 0.0198 mL 0.0992 mL 0.1985 mL 0.4962 mL
100 mM 0.0159 mL 0.0794 mL 0.1588 mL 0.3970 mL
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AZ13705339 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ137053392016806-57-6AZ 13705339AZ-13705339PAKp21 activated kinasesAnticancerRat hepatocytesSigleceosinophilInhibitorinhibitorinhibit

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