1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. PAK
  3. AZ13705339 hemihydrate

AZ13705339 hemihydrate 

Cat. No.: HY-120940A
Handling Instructions

AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers.

For research use only. We do not sell to patients.

AZ13705339 hemihydrate Chemical Structure

AZ13705339 hemihydrate Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of AZ13705339 hemihydrate:

Top Publications Citing Use of Products

View All PAK Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers[1].

IC50 & Target[1]

PAK2

0.32 nM (Kd)

PAK1

0.28 nM (Kd)

PAK1

0.33 nM (IC50)

pPAK1

59 nM (IC50)

In Vitro

AZ13705339 (1 μM) hemihydrate inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells[2].
AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZ13705339 hemihydrate (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

638.77

Formula

C33H36FN7O3S.1/2H2O

SMILES

N#CC1=CC=CC=C1CN(C2=NC(NC3=CC=C(N4CCN(C)CC4)C(S(=O)(CC)=O)=C3)=NC=C2F)C5=CC(CO)=CC=C5C.[1/2].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (156.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5655 mL 7.8275 mL 15.6551 mL
5 mM 0.3131 mL 1.5655 mL 3.1310 mL
10 mM 0.1566 mL 0.7828 mL 1.5655 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AZ13705339 hemihydrate
Cat. No.:
HY-120940A
Quantity:
MCE Japan Authorized Agent: