AZ13705339 hemihydrate

Name: AZ13705339 hemihydrate
Brand: MedChemExpress
SKU: HY-120940A
Rating: 4.5 (1 reviews)

Cat. No.: HY-120940A Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC₅₀s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with K_ds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers.

For research use only. We do not sell to patients.

AZ13705339 hemihydrate Chemical Structure

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 351	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 351	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of AZ13705339 hemihydrate:

AZ13705339 In-stock

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•Related Screening Libraries:

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View All PAK Isoform Specific Products:

View All Isoforms

PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

PAK2

0.32 nM (Kd)

PAK1

0.28 nM (Kd)

PAK1

0.33 nM (IC₅₀)

pPAK1

59 nM (IC₅₀)

In Vitro

AZ13705339 (1 μM) hemihydrate inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells^[2].
AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZ13705339 hemihydrate (100 mg/kg, P.O.) has moderate clearance and oral C_max of 7.7 μM in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

638.77

Formula

C₃₃H₃₆FN₇O₃S.1/2H₂O

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=CC=C1CN(C2=NC(NC3=CC=C(N4CCN(C)CC4)C(S(=O)(CC)=O)=C3)=NC=C2F)C5=CC(CO)=CC=C5C.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (156.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5655 mL	7.8275 mL	15.6551 mL
5 mM	0.3131 mL	1.5655 mL	3.1310 mL
10 mM	0.1566 mL	0.7828 mL	1.5655 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (286 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. McCoull W, et al. Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. ACS Med Chem Lett. 2016;7(12):1118-1123. Published 2016 Sep 14. [Content Brief]

[2]. Martin F M de Rooij, et al. A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways. Nat Commun. 2022 Apr 19;13(1):2136. [Content Brief]

[3]. Daniela J Carroll, et al. Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro. Front Immunol. 2021 Oct 11;12:737988. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5655 mL	7.8275 mL	15.6551 mL	39.1377 mL
	5 mM	0.3131 mL	1.5655 mL	3.1310 mL	7.8275 mL
	10 mM	0.1566 mL	0.7828 mL	1.5655 mL	3.9138 mL
	15 mM	0.1044 mL	0.5218 mL	1.0437 mL	2.6092 mL
	20 mM	0.0783 mL	0.3914 mL	0.7828 mL	1.9569 mL
	25 mM	0.0626 mL	0.3131 mL	0.6262 mL	1.5655 mL
	30 mM	0.0522 mL	0.2609 mL	0.5218 mL	1.3046 mL
	40 mM	0.0391 mL	0.1957 mL	0.3914 mL	0.9784 mL
	50 mM	0.0313 mL	0.1566 mL	0.3131 mL	0.7828 mL
	60 mM	0.0261 mL	0.1305 mL	0.2609 mL	0.6523 mL
	80 mM	0.0196 mL	0.0978 mL	0.1957 mL	0.4892 mL
	100 mM	0.0157 mL	0.0783 mL	0.1566 mL	0.3914 mL