162359-56-0
162359-56-0
Chemical Structure
Fingolimod hydrochloride
Synonym(s): FTY720
- CAS 番号: 162359-56-0
- Formula:C19H34ClNO2
- Molecular Weight:343.93
IUPAC Name: 2-amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride
InChIKey: SWZTYAVBMYWFGS-UHFFFAOYSA-N
SMILES: OCC(N)(CO)CCC1=CC=C(C=C1)CCCCCCCC.[H]Cl
Biological Activity: Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant[1][2][3][4].
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Fingolimod hydrochloride | 99.94% | Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant. | ||||||||||||||||||||
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Fingolimod hydrochloride (Standard) | ≥98% | Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator. | ||||||||||||||||||||
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Fingolimod-d4 hydrochloride | 99.0% | Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-11063Fingolimod -
Similarity Score 0.89
HY-12897(R)-FTY720-OMe -
Similarity Score 0.80
HY-114061(R)-FTY 720P -
Similarity Score 0.80
HY-15381RFingolimod phosphate (Standard) -
Similarity Score 0.80
HY-15382FTY720 (S)-Phosphate -
Similarity Score 0.80
HY-15382A(S)-FTY720-phosphonate -
Similarity Score 0.80
HY-123439FTY720-C2 -
Similarity Score 0.78
HY-11063SFingolimod-d4 -
Similarity Score 0.75
HY-124863A(R)-AAL -
Explore the MedChemAI to find more analogs
References
- [1]. Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586. [Content Brief]
- [2]. Coldewey SM, et al. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep. 2016 Jun 9;6:27594. [Content Brief]
- [3]. Cipriani R, et al. FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation. 2015 May 8;12:86. [Content Brief]
- [4]. Arielle M Bryan, et al. Sphingosine-1-phosphate receptors and innate immunity. Cell Microbiol. 2018 May;20(5):e12836. [Content Brief]
