1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. PAK

G-5555 

Cat. No.: HY-19635 Purity: 99.18%
Data Sheet SDS Handling Instructions

G-5555 is a selective PAK1 Inhibitor (Ki=3.7 nM).

For research use only. We do not sell to patients.
G-5555 Chemical Structure

G-5555 Chemical Structure

CAS No. : 1648863-90-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $380 In-stock
1 mg $150 In-stock
5 mg $350 In-stock
10 mg $600 In-stock
25 mg $1200 In-stock
50 mg $1750 In-stock
100 mg $2300 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

G-5555 is a selective PAK1 Inhibitor (Ki=3.7 nM). IC50 value: 3.7 nM (Ki) [1] Target:PAK1 in vitro: G-5555 is potent, showing good activity in the pMEK cellular assay (IC50=69 nM), has improved permeability, and importantly, displayed low hERG channel activity (<50% inhibition at 10 μM). G-5555 shows excellent kinase selectivity and inhibits only eight out of the 235 kinases tested other than PAK1 with inhibition >70%: PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1. The IC50 of G-5555 against these kinases are 11 nM, 9 mM, and 10 nM for PAK2, SIK2, KHS1, respectively.[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0286 mL 10.1428 mL 20.2856 mL
5 mM 0.4057 mL 2.0286 mL 4.0571 mL
10 mM 0.2029 mL 1.0143 mL 2.0286 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

492.96

Formula

C₂₅H₂₅ClN₆O₃

CAS No.

1648863-90-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 27 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.18%

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Product Name:
G-5555
Cat. No.:
HY-19635
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