SORBS1 - sorbin and SH3 domain containing 1 Gene

Also Known as CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10580

About SORBS1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:95,311,773-95,561,371 (from NCBI)

This gene has 23 transcripts (splice variants), 200 orthologues and 12 paralogues. Broad expression in fat (RPKM 111.7), heart (RPKM 81.6) and 15 other tissues.

Summary

This gene encodes a CBL-associated protein which functions in the signaling and stimulation of Insulin. Mutations in this gene may be associated with human disorders of Insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

SORBS1 Products (44)

mRNA Protein Name
NM_001034954.3 NP_001030126.2 sorbin and SH3 domain-containing protein 1 isoform 3
NM_001034955.2 NP_001030127.2 sorbin and SH3 domain-containing protein 1 isoform 4
NM_001034956.2 NP_001030128.2 sorbin and SH3 domain-containing protein 1 isoform 5
NM_001034957.3 NP_001030129.2 sorbin and SH3 domain-containing protein 1 isoform 7
NM_001290294.2 NP_001277223.2 sorbin and SH3 domain-containing protein 1 isoform 8
NM_001290295.2 NP_001277224.2 sorbin and SH3 domain-containing protein 1 isoform 9
NM_001290296.2 NP_001277225.2 sorbin and SH3 domain-containing protein 1 isoform 10
NM_001290297.3 NP_001277226.2 sorbin and SH3 domain-containing protein 1 isoform 11
NM_001290298.3 NP_001277227.2 sorbin and SH3 domain-containing protein 1 isoform 12
NM_001377197.1 NP_001364126.1 sorbin and SH3 domain-containing protein 1 isoform 13
NM_001377198.1 NP_001364127.1 sorbin and SH3 domain-containing protein 1 isoform 14
NM_001377199.1 NP_001364128.1 sorbin and SH3 domain-containing protein 1 isoform 15
NM_001377200.1 NP_001364129.1 sorbin and SH3 domain-containing protein 1 isoform 16
NM_001377201.1 NP_001364130.1 sorbin and SH3 domain-containing protein 1 isoform 17
NM_001377202.1 NP_001364131.1 sorbin and SH3 domain-containing protein 1 isoform 18
NM_001377203.1 NP_001364132.1 sorbin and SH3 domain-containing protein 1 isoform 19
NM_001377204.1 NP_001364133.1 sorbin and SH3 domain-containing protein 1 isoform 20
NM_001377205.1 NP_001364134.1 sorbin and SH3 domain-containing protein 1 isoform 21
NM_001377206.1 NP_001364135.1 sorbin and SH3 domain-containing protein 1 isoform 22
NM_001377207.1 NP_001364136.1 sorbin and SH3 domain-containing protein 1 isoform 23
NM_001377208.1 NP_001364137.1 sorbin and SH3 domain-containing protein 1 isoform 24
NM_001377209.1 NP_001364138.1 sorbin and SH3 domain-containing protein 1 isoform 25
NM_001384447.1 NP_001371376.1 sorbin and SH3 domain-containing protein 1 isoform 26
NM_001384448.1 NP_001371377.1 sorbin and SH3 domain-containing protein 1 isoform 27
NM_001384449.1 NP_001371378.1 sorbin and SH3 domain-containing protein 1 isoform 28
NM_001384450.1 NP_001371379.1 sorbin and SH3 domain-containing protein 1 isoform 29
NM_001384451.1 NP_001371380.1 sorbin and SH3 domain-containing protein 1 isoform 30
NM_001384452.1 NP_001371381.1 sorbin and SH3 domain-containing protein 1 isoform 31
NM_001384453.1 NP_001371382.1 sorbin and SH3 domain-containing protein 1 isoform 32
NM_001384454.1 NP_001371383.1 sorbin and SH3 domain-containing protein 1 isoform 32
NM_001384455.1 NP_001371384.1 sorbin and SH3 domain-containing protein 1 isoform 11
NM_001384456.1 NP_001371385.1 sorbin and SH3 domain-containing protein 1 isoform 11
NM_001384457.1 NP_001371386.1 sorbin and SH3 domain-containing protein 1 isoform 11
NM_001384458.1 NP_001371387.1 sorbin and SH3 domain-containing protein 1 isoform 33
NM_001384459.1 NP_001371388.1 sorbin and SH3 domain-containing protein 1 isoform 34
NM_001384460.1 NP_001371389.1 sorbin and SH3 domain-containing protein 1 isoform 35
NM_001384461.1 NP_001371390.1 sorbin and SH3 domain-containing protein 1 isoform 36
NM_001384462.1 NP_001371391.1 sorbin and SH3 domain-containing protein 1 isoform 37
NM_001384463.1 NP_001371392.1 sorbin and SH3 domain-containing protein 1 isoform 38
NM_001384464.1 NP_001371393.1 sorbin and SH3 domain-containing protein 1 isoform 39
NM_001384465.1 NP_001371394.1 sorbin and SH3 domain-containing protein 1 isoform 40
NM_006434.4 NP_006425.3 sorbin and SH3 domain-containing protein 1 isoform 1
NM_015385.4 NP_056200.2 sorbin and SH3 domain-containing protein 1 isoform 2
NM_024991.3 NP_079267.2 sorbin and SH3 domain-containing protein 1 isoform 6

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables insulin receptor binding IDA
IDA: Inferred from direct assay
11374898 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11371513 GOA
enables signaling receptor complex adaptor activity IDA
IDA: Inferred from direct assay
11374898 GOA
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
11371513 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SORBS1 Protein Structure

Sorb

Sorb: Sorbin homologous domain (367 - 407)

SH3_2

SH3_2: Variant SH3 domain (798 - 848)

SH3_9

SH3_9: Variant SH3 domain (874 - 924)

SH3_9

SH3_9: Variant SH3 domain (1238 - 1288)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1292 a.a.
Protein Preferred Names Protein Names

sorbin and SH3 domain-containing protein 1

  • Fas-ligand associated factor 2

SORBS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SORBS1 Q9BX66 PAK2 Homo sapiens Q13177
Phage Display
16374509
Intra
SORBS1 Q9BX66 INPPL1 Homo sapiens O15357
Y2H
12504111
Intra
SORBS1 Q9BX66 INPPL1 Homo sapiens O15357
Pull Down
12504111
Intra
SORBS1 Q9BX66 INPPL1 Homo sapiens O15357
Anti Tag CoIP
12504111
Intra
SORBS1 Q9BX66 ABL1 Homo sapiens P00519
Anti Bait CoIP
11374898
Intra
SORBS1 Q9BX66 HTT Homo sapiens P42858
Y2H
17500595
Intra
SORBS1 Q9BX66 ATXN7 Homo sapiens O15265
IF
23892081
Intra
SORBS1 Q9BX66 ATXN7 Homo sapiens O15265
ITC
23892081
Intra
SORBS1 Q9BX66 ATXN7 Homo sapiens O15265
NMR
23892081
Intra
SORBS1 Q9BX66 ATXN7 Homo sapiens O15265
Pull Down
23892081
Cross
SORBS1 Q9BX66 Dnm2 Rattus norvegicus P39052
Pull Down
19116150
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13567 SORBS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SORBS1 VGNC VGNC:77702
Bos taurus SORBS1 VGNC VGNC:55972
Canis familiaris SORBS1 VGNC VGNC:46657
Rattus norvegicus SORBS1 RGD RGD:1586598
Mus musculus SORBS1 MGD MGI:700014
Felis catus SORBS1 VGNC VGNC:65569
Others SORBS1 NCBI