RHOJ - ras homolog family member J Gene

Also Known as TCL; ARHJ; TC10B; RASL7B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57381

About RHOJ

Cytogenetic location: 14q23.2 Genomic coordinates (GRCh38): 14:63,204,443-63,293,508 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 22 paralogues. Ubiquitous expression in gall bladder (RPKM 9.9), lung (RPKM 9.2) and 23 other tissues.

Summary

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

RHOJ Products (1)

mRNA Protein Name
NM_020663.5 NP_065714.1 rho-related GTP-binding protein RhoJ

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
27660391 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
27660391 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
10967094 GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
28727754 GOA
involved in regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
30158707 GOA
involved in regulation of sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
21628409 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
27660391 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOJ Protein Structure

Ras

Ras: Ras family (23 - 194)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

rho-related GTP-binding protein RhoJ

  • RAS-like, family 7, member B

RHOJ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RHOJ Q9H4E5 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
25416956
Intra
RHOJ Q9H4E5 SSX3 Homo sapiens Q99909
Y2H Array
25416956
Intra
RHOJ Q9H4E5 SSX3 Homo sapiens Q99909
Anti Tag CoIP
25416956
Intra
RHOJ Q9H4E5 PAK2 Homo sapiens Q13177
Y2H Array
25416956
Intra
RHOJ Q9H4E5 PAK2 Homo sapiens Q13177
Anti Tag CoIP
33961781
Intra
RHOJ Q9H4E5 PAK2 Homo sapiens Q13177
Y2H Prey Pooling
25416956
Intra
RHOJ Q9H4E5 PAK2 Homo sapiens Q13177
Validated Y2H
25416956
Intra
RHOJ Q9H4E5 PAK6 Homo sapiens Q9NQU5
Y2H Array
31515488
Intra
RHOJ Q9H4E5 PAK6 Homo sapiens Q9NQU5
Y2H Array
25416956
Intra
RHOJ Q9H4E5 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
RHOJ Q9H4E5 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
RHOJ Q9H4E5 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
RHOJ Q9H4E5 PAK1 Homo sapiens Q13153
Anti Tag CoIP
33961781
Intra
RHOJ Q9H4E5 PAK1 Homo sapiens Q13153
Validated Y2H
32814053
Intra
RHOJ Q9H4E5 PAK1 Homo sapiens Q13153
Y2H Array
32814053
Intra
RHOJ Q9H4E5 PAK1 Homo sapiens Q13153
Y2H Pooling
32814053
Intra
RHOJ Q9H4E5 PAK3 Homo sapiens O75914-2
Y2H Array
32296183
Intra
RHOJ Q9H4E5 PAK3 Homo sapiens O75914-2
Y2H Prey Pooling
32296183
Intra
RHOJ Q9H4E5 BLZF1 Homo sapiens Q9H2G9
Y2H Array
25416956
Intra
RHOJ Q9H4E5 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
25416956
Intra
RHOJ Q9H4E5 PARD6B Homo sapiens Q9BYG5
Y2H Array
32296183
Intra
RHOJ Q9H4E5 PARD6B Homo sapiens Q9BYG5
Anti Tag CoIP
33961781
Intra
RHOJ Q9H4E5 PARD6B Homo sapiens Q9BYG5
Validated Y2H
25416956
Intra
RHOJ Q9H4E5 PARD6B Homo sapiens Q9BYG5
Y2H Prey Pooling
32296183
Intra
RHOJ Q9H4E5 PARD6B Homo sapiens Q9BYG5
Y2H Array
25416956
Intra
RHOJ Q9H4E5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
RHOJ Q9H4E5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
RHOJ Q9H4E5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
RHOJ Q9H4E5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RHOJ Q9H4E5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RHOJ Q9H4E5 CRYAA Homo sapiens P02489
Y2H Array
32814053
Intra
RHOJ Q9H4E5 CRYAA Homo sapiens P02489
Y2H Pooling
32814053
Intra
RHOJ Q9H4E5 CRYAA Homo sapiens P02489
Validated Y2H
32814053
Intra
RHOJ Q9H4E5 BHLHE40 Homo sapiens O14503
Validated Y2H
25416956
Intra
RHOJ Q9H4E5 TRIP10 Homo sapiens Q15642
Y2H Array
25416956
Intra
RHOJ Q9H4E5 TRIP10 Homo sapiens Q15642
Y2H Prey Pooling
25416956
Intra
RHOJ Q9H4E5 PAK5 Homo sapiens Q9P286
Y2H Prey Pooling
32296183
Intra
RHOJ Q9H4E5 PAK5 Homo sapiens Q9P286
Validated Y2H
32296183
Intra
RHOJ Q9H4E5 PAK5 Homo sapiens Q9P286
Y2H Array
32296183
Intra
RHOJ Q9H4E5 ZNF426 Homo sapiens Q9BUY5
Y2H Prey Pooling
32296183
Intra
RHOJ Q9H4E5 ZNF426 Homo sapiens Q9BUY5
Y2H Array
32296183
Intra
RHOJ Q9H4E5 CDC42EP1 Homo sapiens Q00587
Validated Y2H
25416956
Intra
RHOJ Q9H4E5 GLUL Homo sapiens P15104
Anti Bait CoIP
30158707
Intra
RHOJ Q9H4E5 WASL Homo sapiens O00401
Validated Y2H
25416956
Intra
RHOJ Q9H4E5 WASL Homo sapiens O00401
Y2H Prey Pooling
32296183
Intra
RHOJ Q9H4E5 WASL Homo sapiens O00401
Y2H Prey Pooling
25416956
Intra
RHOJ Q9H4E5 WASL Homo sapiens O00401
Y2H Array
25416956
Intra
RHOJ Q9H4E5 WASL Homo sapiens O00401
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

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Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2749 Glutamine synthetase / Unkown
HY-RS11955 RHOJ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-167828 ARN25062 Inhibitor / Unkown
HY-RS18786 Rhoj Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25275 Rhoj Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RHOJ VGNC VGNC:76885
Felis catus RHOJ VGNC VGNC:80867
Bos taurus RHOJ VGNC VGNC:33951
Canis familiaris RHOJ VGNC VGNC:45562
Rattus norvegicus RHOJ RGD RGD:1310528
Mus musculus RHOJ MGD MGI:1931551
Others RHOJ NCBI