ARN25062
ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative.
For research use only. We do not sell to patients.
- CAS No.: 3036492-85-7
- Formula: C22H21F3N4
- Molecular Weight:398.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative[1].
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
5.1 μM
Compound: 27; ARN25062
|
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
|
[PMID: 37026468] |
| A-375 | IC50 |
5.1 μM
Compound: ARN25062
|
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
|
[PMID: 38866385] |
| SK-MEL-28 | IC50 |
6.1 μM
Compound: 27; ARN25062
|
Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
|
[PMID: 37026468] |
| SK-MEL-28 | IC50 |
6.1 μM
Compound: ARN25062
|
Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
|
[PMID: 38866385] |
| SK-MEL3 | IC50 |
4.6 μM
Compound: 27; ARN25062
|
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
|
[PMID: 37026468] |
| SK-MEL3 | IC50 |
4.6 μM
Compound: ARN25062
|
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
|
[PMID: 38866385] |
| SW480 | IC50 |
5.9 μM
Compound: 27; ARN25062
|
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
|
[PMID: 37026468] |
| SW480 | IC50 |
5.9 μM
Compound: ARN25062
|
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
|
[PMID: 38866385] |
Chemical Information
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CAS No. 3036492-85-7
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Molecular Weight 398.42
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Formula C22H21F3N4
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SMILES
FC(F)(C1=CC(NC2=CC(C3=CC=CC=C3)=NC(C4CCNCC4)=N2)=CC=C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
References
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