WASL - WASP like actin nucleation promoting factor Gene

Also Known as NWASP; WASPB; N-WASP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8976

About WASL

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,681,943-123,749,003 (from NCBI)

This gene has 1 transcript (splice variant), 256 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 25.7), thyroid (RPKM 23.4) and 25 other tissues.

Summary

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin Cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

WASL Products (1)

mRNA	Protein	Name
NM_003941.4	NP_003932.3	actin nucleation-promoting factor WASL

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11231575	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament polymerization	IDA IDA: Inferred from direct assay	16767080	GOA
involved in negative regulation of lymphocyte migration	IMP IMP: Inferred from mutant phenotype	22585739	GOA
involved in negative regulation of membrane tubulation	IDA IDA: Inferred from direct assay	18388313	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16767080	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	18388313	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16767080	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WASL Protein Structure

WH1

PBD

WH2

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
actin nucleation-promoting factor WASL	Wiskott-Aldrich syndrome like

WASL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WASL	O00401	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	WASL	O00401	ARHGAP12	Homo sapiens	Q8IWW6-4	Validated Y2H	32296183
Intra	WASL	O00401	SORBS2	Homo sapiens	O94875-10	Validated Y2H	32296183
Intra	WASL	O00401	SORBS3	Homo sapiens	O60504-2	Anti Tag CoIP	18662323
Intra	WASL	O00401	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	WASL	O00401	PTK6	Homo sapiens	Q13882	Y2H Prey Pooling	25416956
Intra	WASL	O00401	PTK6	Homo sapiens	Q13882	Y2H Array	25416956
Intra	WASL	O00401	NCK1	Homo sapiens	P16333-1	Pull Down	16595635
Cross	WASL	O00401	espF(U)	Escherichia coli O157:H7	Q8X482	Anti Tag CoIP	15296718
Cross	WASL	O00401	espF(U)	Escherichia coli O157:H7	Q8X482	IF	15296718
Intra	WASL	O00401	WIPF2	Homo sapiens	Q8TF74	Anti Tag CoIP	33961781
Intra	WASL	O00401	WIPF2	Homo sapiens	Q8TF74	Anti Tag CoIP	28514442
Intra	WASL	O00401	WIPF2	Homo sapiens	Q8TF74	Validated Y2H	32296183
Intra	WASL	O00401	WIPF2	Homo sapiens	Q8TF74	Anti Tag CoIP	35271311
Intra	WASL	O00401	WIPF2	Homo sapiens	Q8TF74	Y2H Fragment Pooling	23414517
Intra	WASL	O00401	WIPF1	Homo sapiens	O43516	Anti Tag CoIP	35271311
Intra	WASL	O00401	WIPF1	Homo sapiens	O43516	Anti Bait CoIP	16582881
Intra	WASL	O00401	WIPF1	Homo sapiens	O43516	Anti Tag CoIP	33961781
Intra	WASL	O00401	WIPF1	Homo sapiens	O43516	Y2H	11331876
Intra	WASL	O00401	WIPF1	Homo sapiens	O43516	Validated Y2H	25416956
Intra	WASL	O00401	WIPF1	Homo sapiens	O43516	Anti Tag CoIP	28514442
Intra	WASL	O00401	WIPF1	Homo sapiens	O43516	Y2H Fragment Pooling	23414517
Intra	WASL	O00401	ARPC3	Homo sapiens	O15145	Validated Y2H	32296183
Intra	WASL	O00401	ARPC3	Homo sapiens	O15145	Y2H Array	25416956
Intra	WASL	O00401	ARPC3	Homo sapiens	O15145	Y2H Prey Pooling	25416956
Intra	WASL	O00401	ARPC4	Homo sapiens	P59998	Validated Y2H	32296183
Intra	WASL	O00401	CIB1	Homo sapiens	Q99828	Y2H	16582881
Intra	WASL	O00401	CIB1	Homo sapiens	Q99828	Anti Bait CoIP	16582881
Intra	WASL	O00401	RNF8	Homo sapiens	O76064	Y2H Array	31515488
Intra	WASL	O00401	RNF8	Homo sapiens	O76064	Validated Y2H	25416956
Intra	WASL	O00401	RNF8	Homo sapiens	O76064	Validated Y2H	32296183
Intra	WASL	O00401	RNF8	Homo sapiens	O76064	Y2H Array	25416956
Intra	WASL	O00401	RNF8	Homo sapiens	O76064	Y2H Prey Pooling	25416956
Intra	WASL	O00401	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	WASL	O00401	WIPF3	Homo sapiens	A6NGB9	Anti Tag CoIP	33961781
Intra	WASL	O00401	WIPF3	Homo sapiens	A6NGB9	Anti Tag CoIP	28514442
Intra	WASL	O00401	WIPF3	Homo sapiens	A6NGB9	Anti Tag CoIP	35271311
Intra	WASL	O00401	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	WASL	O00401	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	WASL	O00401	RHOJ	Homo sapiens	Q9H4E5	Validated Y2H	32296183
Intra	WASL	O00401	TRIP10	Homo sapiens	Q15642-2	Validated Y2H	32296183
Intra	WASL	O00401	NCK2	Homo sapiens	O43639	Validated Y2H	25416956
Intra	WASL	O00401	PAK4	Homo sapiens	O96013	Enzymatic Study	29100370
Intra	WASL	O00401	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	WASL	O00401	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	WASL	O00401	SDCBP	Homo sapiens	O00560	Validated Y2H	32296183
Intra	WASL	O00401	UBASH3A	Homo sapiens	P57075-2	Validated Y2H	32296183
Intra	WASL	O00401	PACSIN2	Homo sapiens	Q9UNF0	Validated Y2H	32296183
Intra	WASL	O00401	PACSIN3	Homo sapiens	Q9UKS6	Validated Y2H	32296183
Intra	WASL	O00401	CDC42	Homo sapiens	P60953	CoIP	15834156
Cross	WASL	O00401	Fnbp1	Rattus norvegicus	Q8R511	Pull Down	14732713
Cross	WASL	O00401	ACTR3	Bos taurus	P61157	Pull Down	16253999
Cross	WASL	O00401	ACTR3	Bos taurus	P61157	Pull Down	11231575
Cross	WASL	O00401	ACTR3	Bos taurus	P61157	Pull Down	12732638
Cross	WASL	O00401	ACTA1	Oryctolagus cuniculus	P68135	Pull Down	11231575

Cross: Cross-species interaction Intra: Intraspecies interaction

WASL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81720	N WASP Antibody (YA1465)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse
HY-P81720A	N WASP Antibody (YA1465)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Buruli Ulcer	Buruli Ulcer, Susceptibility To Buruli Ulcer Disease Mycobacterium Ulcerans Mycobacterium Ulcerans, Susceptibility To Bairnsdale Ulcer Daintree Ulcer Mossman Ulcer Searl Ulcer Searle'S Ulcer Bud
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2	Aoa2 Ataxia With Oculomotor Apraxia Type 2 Scar1 SCAN2 Ataxia-Oculomotor Apraxia 2 Ataxia-Ocular Apraxia 2 Ataxia-Oculomotor Apraxia Type 2 Scan 2 Spinocerebellar Ataxia With Axonal Neuropathy Type 2 Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly Scar1, Formerly Autosomal Recessive Spinocerebellar Ataxia-1 Spinocerebellar Ataxia, Autosomal Recessive, 1 Ataxia-Ocular Apraxia-2 Spinocerebellar Ataxia, Autosomal Recessive 1
Vaccinia
Myopathy, Centronuclear, 2	Myopathy, Centronuclear, Autosomal Recessive Autosomal Recessive Centronuclear Myopathy CNM2 Centronuclear Myopathy 2 Ar-Cnm Myotubular Myopathy, Autosomal Recessive Autosomal Recessive Myotubular Myopathy Centronuclear Myopathy Autosomal Recessive Myopathy, Centronuclear, Type 2
Lower Lip Cancer
Aarskog-Scott Syndrome	Aarskog Syndrome Faciogenital Dysplasia Faciodigitogenital Syndrome AAS Fgdy X-Linked Aarskog Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 16 Aarskog Syndrome, X-Linked Intellectual Developmental Disorder, X-Linked Syndromic 16 Greig'S Syndrome Aarskog Scott Syndrome Aarskog Disease Scott Aarskog Syndrome Facio-Digito-Genital Dysplasia Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder Aarskog-Scott Syndrome ) Syndrome
Frank-Ter Haar Syndrome	Ter Haar Syndrome Borrone Dermatocardioskeletal Syndrome FTHS Autosomal Recessive Melnick-Needles Syndrome Borrone Di Rocco Crovato Syndrome Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay Melnick-Needles Syndrome, Autosomal Recessive, Formerly Frank Ter Haar Syndrome
Neutropenia, Severe Congenital, X-Linked	X-Linked Severe Congenital Neutropenia XLN SCNX Severe Congenital Neutropenia X-Linked Neutropenia, Congenital, Severe, X-Linked
Shigellosis	Dysentery, Bacillary Bacillary Dysentery Shigella Boydii Infectious Disease Shigella Flexneri Infectious Disease Shigella Gastroenteritis Shigella Sonnei Infectious Disease Shigella Infections
Otopalatodigital Syndrome Spectrum Disorder	Opd Spectrum Disorder Opsd Fronto-Otopalatodigital Osteodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15747	WASL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WASL	RGD	RGD:735144
Mus musculus	WASL	MGD	MGI:1920428
Canis familiaris	WASL	VGNC	VGNC:58887
Bos taurus	WASL	VGNC	VGNC:56336
Macaca mulatta	WASL	VGNC	VGNC:78783
Felis catus	WASL	VGNC	VGNC:67007
Others	WASL	NCBI