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WIPF1 - WAS/WASL interacting protein family member 1 Gene

Also Known as WIP; WAS2; PRPL-2; WASPIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7456

About WIPF1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:174,559,574-174,682,913 (from NCBI)

This gene has 26 transcripts (splice variants), 169 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 61.9), appendix (RPKM 50.1) and 23 other tissues.

Summary

This gene encodes a protein that plays an important role in the organization of the actin Cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

WIPF1 Products (10)

mRNA	Protein	Name
NM_001077269.1	NP_001070737.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375832.1	NP_001362761.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375833.1	NP_001362762.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375834.1	NP_001362763.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375835.1	NP_001362764.1	WAS/WASL-interacting protein family member 1 isoform b
NM_001375836.1	NP_001362765.1	WAS/WASL-interacting protein family member 1 isoform c
NM_001375837.1	NP_001362766.1	WAS/WASL-interacting protein family member 1 isoform c
NM_001375838.1	NP_001362767.1	WAS/WASL-interacting protein family member 1 isoform c
NM_001375839.1	NP_001362768.1	WAS/WASL-interacting protein family member 1 isoform d
NM_003387.5	NP_003378.3	WAS/WASL-interacting protein family member 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19798448	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9405671	GOA
enables protein folding chaperone	EXP EXP: Inferred from Experiment	23870269	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WIPF1 Protein Structure

WH2

0
100
200
300
400
503 a.a.

Protein Preferred Names	Protein Names
WAS/WASL-interacting protein family member 1	WASP-interacting protein

WIPF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WIPF1	O43516	FASTK	Homo sapiens	Q14296	Y2H Prey Pooling	25416956
Intra	WIPF1	O43516	HCK	Homo sapiens	P08631	Pull Down	12029088
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Validated Y2H	25416956
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H	16488394
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H Array	25416956
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H	9405671
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Pull Down	16488394
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	IF	19817875
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H Array	21988832
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Pull Down	9405671
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Anti Bait CoIP	17213309
Intra	WIPF1	O43516	NCK1	Homo sapiens	P16333	Pull Down	12620186
Intra	WIPF1	O43516	ALAS1	Homo sapiens	P13196	Y2H Array	25416956
Cross	WIPF1	O43516	Cttn	Mus musculus	Q60598	Pull Down	12620186
Intra	WIPF1	O43516	GRB2	Homo sapiens	P62993	Y2H Array	21988832
Intra	WIPF1	O43516	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	WIPF1	O43516	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	WIPF1	O43516	ABI2	Homo sapiens	Q9NYB9	Y2H Array	25416956
Intra	WIPF1	O43516	WWP2	Homo sapiens	O00308	Y2H Array	25416956
Intra	WIPF1	O43516	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	WIPF1	O43516	SEC24C	Homo sapiens	P53992	Y2H Prey Pooling	25416956
Intra	WIPF1	O43516	SEC24C	Homo sapiens	P53992	Validated Y2H	25416956
Intra	WIPF1	O43516	SEC24C	Homo sapiens	P53992	Y2H Array	25416956
Intra	WIPF1	O43516	WASL	Homo sapiens	O00401	Y2H Prey Pooling	25416956
Intra	WIPF1	O43516	WASL	Homo sapiens	O00401	Y2H	11331876
Intra	WIPF1	O43516	WASL	Homo sapiens	O00401	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome 2	WAS2 Wipf1 Deficiency Wip Deficiency
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Neutropenia, Severe Congenital, X-Linked	X-Linked Severe Congenital Neutropenia XLN SCNX Severe Congenital Neutropenia X-Linked Neutropenia, Congenital, Severe, X-Linked
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia	Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease IMD71 Plteid Immunodeficiency 71
Pedophilia	Paedophilia
Ceroid Lipofuscinosis, Neuronal, 6a	Neuronal Ceroid Lipofuscinosis 6 CLN6 Vlincl Cln6 Disease Ceroid Lipofuscinosis, Neuronal, 6 Late-Infantile Neuronal Ceroid Lipofuscinosis CLN6A Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant Neuronal Ceroid Lipofuscinosis 6a Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset Cln6 Disease, Adult Kufs Type A Cln6 Disease, Late Infantile Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant Ceroid Lipofuscinosis Neuronal 6 Cln6-Related Neuronal Ceroid Lipofuscinosis Late Infantile Neuronal Ceroid Lipofuscinosis Jansky-Bielschowsky Disease Lincl Late Infantile Ncl Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant Lipofuscinosis, Ceroid, Neuronal, Type 6 Ceroid Lipofuscinosis, Neuronal, 5
Subendocardial Myocardial Infarction
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15817	WIPF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WIPF1	VGNC	VGNC:67073
Macaca mulatta	WIPF1	VGNC	VGNC:78784
Canis familiaris	WIPF1	VGNC	VGNC:48410
Bos taurus	WIPF1	VGNC	VGNC:36939
Rattus norvegicus	WIPF1	RGD	RGD:620887
Mus musculus	WIPF1	MGD	MGI:2178801
Others	WIPF1	NCBI