ABI2 - abl interactor 2 Gene

Also Known as AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10152

About ABI2

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:203,328,394-203,432,169 (from NCBI)

This gene has 24 transcripts (splice variants), 201 orthologues and 2 paralogues. Broad expression in brain (RPKM 35.9), thyroid (RPKM 13.9) and 21 other tissues.

Summary

Enables several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein Ligase binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including filopodium tip; lamellipodium; and nucleoplasm. Part of SCAR complex. Is active in adherens junction. Colocalizes with actin filament. [provided by Alliance of Genome Resources, Apr 2022]

ABI2 Products (88)

mRNA	Protein	Name
NM_001282925.3	NP_001269854.1	abl interactor 2 isoform a
NM_001282926.3	NP_001269855.1	abl interactor 2 isoform b
NM_001282927.2	NP_001269856.1	abl interactor 2 isoform d
NM_001282932.2	NP_001269861.1	abl interactor 2 isoform e
NM_001375662.1	NP_001362591.1	abl interactor 2 isoform f
NM_001375663.1	NP_001362592.1	abl interactor 2 isoform f
NM_001375664.1	NP_001362593.1	abl interactor 2 isoform g
NM_001375665.1	NP_001362594.1	abl interactor 2 isoform g
NM_001375666.1	NP_001362595.1	abl interactor 2 isoform h
NM_001375667.1	NP_001362596.1	abl interactor 2 isoform h
NM_001375668.1	NP_001362597.1	abl interactor 2 isoform i
NM_001375669.1	NP_001362598.1	abl interactor 2 isoform i
NM_001375670.1	NP_001362599.1	abl interactor 2 isoform j
NM_001375671.1	NP_001362600.1	abl interactor 2 isoform k
NM_001375672.1	NP_001362601.1	abl interactor 2 isoform l
NM_001375673.1	NP_001362602.1	abl interactor 2 isoform m
NM_001375674.1	NP_001362603.1	abl interactor 2 isoform n
NM_001375675.1	NP_001362604.1	abl interactor 2 isoform o
NM_001375676.1	NP_001362605.1	abl interactor 2 isoform p
NM_001375677.1	NP_001362606.1	abl interactor 2 isoform q
NM_001375678.1	NP_001362607.1	abl interactor 2 isoform r
NM_001375679.1	NP_001362608.1	abl interactor 2 isoform s
NM_001375680.1	NP_001362609.1	abl interactor 2 isoform t
NM_001375681.1	NP_001362610.1	abl interactor 2 isoform u
NM_001375682.1	NP_001362611.1	abl interactor 2 isoform v
NM_001375683.1	NP_001362612.1	abl interactor 2 isoform w
NM_001375684.1	NP_001362613.1	abl interactor 2 isoform x
NM_001375685.1	NP_001362614.1	abl interactor 2 isoform y
NM_001375686.1	NP_001362615.1	abl interactor 2 isoform z
NM_001375687.1	NP_001362616.1	abl interactor 2 isoform aa
NM_001375688.1	NP_001362617.1	abl interactor 2 isoform bb
NM_001375689.1	NP_001362618.1	abl interactor 2 isoform cc
NM_001375690.1	NP_001362619.1	abl interactor 2 isoform dd
NM_001375691.1	NP_001362620.1	abl interactor 2 isoform ee
NM_001375692.1	NP_001362621.1	abl interactor 2 isoform ff
NM_001375693.1	NP_001362622.1	abl interactor 2 isoform gg
NM_001375695.1	NP_001362624.1	abl interactor 2 isoform hh
NM_001375696.1	NP_001362625.1	abl interactor 2 isoform ii
NM_001375698.1	NP_001362627.1	abl interactor 2 isoform jj
NM_001375699.1	NP_001362628.1	abl interactor 2 isoform kk
NM_001375702.1	NP_001362631.1	abl interactor 2 isoform ll
NM_001375704.1	NP_001362633.1	abl interactor 2 isoform mm
NM_001375706.1	NP_001362635.1	abl interactor 2 isoform nn
NM_001375707.1	NP_001362636.1	abl interactor 2 isoform oo
NM_001375708.1	NP_001362637.1	abl interactor 2 isoform pp
NM_001375709.1	NP_001362638.1	abl interactor 2 isoform qq
NM_001375710.1	NP_001362639.1	abl interactor 2 isoform rr
NM_001375711.1	NP_001362640.1	abl interactor 2 isoform ss
NM_001375712.1	NP_001362641.1	abl interactor 2 isoform tt
NM_001375714.1	NP_001362643.1	abl interactor 2 isoform uu
NM_001375717.1	NP_001362646.1	abl interactor 2 isoform vv
NM_001375719.1	NP_001362648.1	abl interactor 2 isoform ww
NM_001375721.1	NP_001362650.1	abl interactor 2 isoform xx
NM_001375722.1	NP_001362651.1	abl interactor 2 isoform yy
NM_001375723.1	NP_001362652.1	abl interactor 2 isoform zz
NM_001375724.1	NP_001362653.1	abl interactor 2 isoform aaa
NM_001375725.1	NP_001362654.1	abl interactor 2 isoform bbb
NM_001375726.1	NP_001362655.1	abl interactor 2 isoform ccc
NM_001375727.1	NP_001362656.1	abl interactor 2 isoform ddd
NM_001375728.1	NP_001362657.1	abl interactor 2 isoform eee
NM_001375729.1	NP_001362658.1	abl interactor 2 isoform fff
NM_001375730.1	NP_001362659.1	abl interactor 2 isoform ggg
NM_001375731.1	NP_001362660.1	abl interactor 2 isoform hhh
NM_001375732.1	NP_001362661.1	abl interactor 2 isoform iii
NM_001375733.1	NP_001362662.1	abl interactor 2 isoform jjj
NM_001375734.1	NP_001362663.1	abl interactor 2 isoform kkk
NM_001375735.1	NP_001362664.1	abl interactor 2 isoform lll
NM_001375736.1	NP_001362665.1	abl interactor 2 isoform mmm
NM_001375737.1	NP_001362666.1	abl interactor 2 isoform nnn
NM_001375738.1	NP_001362667.1	abl interactor 2 isoform ooo
NM_001375739.1	NP_001362668.1	abl interactor 2 isoform ppp
NM_001375740.1	NP_001362669.1	abl interactor 2 isoform rrr
NM_001375741.1	NP_001362670.1	abl interactor 2 isoform sss
NM_001375742.1	NP_001362671.1	abl interactor 2 isoform ttt
NM_001375743.1	NP_001362672.1	abl interactor 2 isoform uuu
NM_001375744.1	NP_001362673.1	abl interactor 2 isoform vvv
NM_001375745.1	NP_001362674.1	abl interactor 2 isoform www
NM_001375746.1	NP_001362675.1	abl interactor 2 isoform xxx
NM_001375747.1	NP_001362676.1	abl interactor 2 isoform yyy
NM_001375748.1	NP_001362677.1	abl interactor 2 isoform zzz
NM_001375749.1	NP_001362678.1	abl interactor 2 isoform aaaa
NM_001375750.1	NP_001362679.1	abl interactor 2 isoform bbbb
NM_001375751.1	NP_001362680.1	abl interactor 2 isoform cccc
NM_001375752.1	NP_001362681.1	abl interactor 2 isoform dddd
NM_001375753.1	NP_001362682.1	abl interactor 2 isoform eeee
NM_001375754.1	NP_001362683.1	abl interactor 2 isoform d
NM_001375755.1	NP_001362684.1	abl interactor 2 isoform qqq
NM_005759.7	NP_005750.4	abl interactor 2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	7590236	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables proline-rich region binding	IPI IPI: Inferred from physical interaction	7590236	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	17101133	GOA
contributes to small GTPase binding	IDA IDA: Inferred from direct assay	21107423	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18632609	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Rac protein signal transduction	IDA IDA: Inferred from direct assay	21107423	GOA
involved in mitophagy	IDA IDA: Inferred from direct assay	38081847	GOA
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	17101133	GOA
involved in positive regulation of Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	21107423	GOA
involved in positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	21107423	GOA
involved in zonula adherens assembly	IMP IMP: Inferred from mutant phenotype	15572692	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCAR complex	IDA IDA: Inferred from direct assay	21107423	GOA
colocalizes with actin filament	IDA IDA: Inferred from direct assay	15572692	GOA
is active in adherens junction	IDA IDA: Inferred from direct assay	15572692	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17101133	GOA
located in filopodium tip	IDA IDA: Inferred from direct assay	11516653	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11516653	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABI2 Protein Structure

Abi_HHR

SH3_9

0
100
200
300
400
513 a.a.

Protein Preferred Names	Protein Names
abl interactor 2	abelson interactor 2

ABI2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ABI2	Q9NYB9	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	ABI2	Q9NYB9	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	EIF3S3	Homo sapiens	Q6IB98	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	EIF3S3	Homo sapiens	Q6IB98	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	EIF3S3	Homo sapiens	Q6IB98	Y2H Array	25416956
Intra	ABI2	Q9NYB9	KIAA1217	Homo sapiens	Q5T5P2-6	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	KIAA1217	Homo sapiens	Q5T5P2-6	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	VARS2	Homo sapiens	Q5ST30-4	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	VARS2	Homo sapiens	Q5ST30-4	Y2H Array	25416956
Intra	ABI2	Q9NYB9	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	ABI2	Q9NYB9	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	ABI2	Q9NYB9	EGLN3	Homo sapiens	Q9H6Z9	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	EGLN3	Homo sapiens	Q9H6Z9	Y2H Array	25416956
Intra	ABI2	Q9NYB9	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
Intra	ABI2	Q9NYB9	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	ABI2	Q9NYB9	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	PRAM1	Homo sapiens	Q96QH2	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	PRAM1	Homo sapiens	Q96QH2	Y2H Array	25416956
Intra	ABI2	Q9NYB9	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	ABI2	Q9NYB9	HNRNPK	Homo sapiens	P61978	Y2H Array	29892012
Intra	ABI2	Q9NYB9	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	ARHGAP32	Homo sapiens	A7KAX9	Y2H Array	25416956
Intra	ABI2	Q9NYB9	WIPF1	Homo sapiens	O43516	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	ABI2	Q9NYB9	NUP62	Homo sapiens	P37198	Y2H Array	31515488
Intra	ABI2	Q9NYB9	STAM2	Homo sapiens	O75886	Y2H Array	25416956
Intra	ABI2	Q9NYB9	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	STAM2	Homo sapiens	O75886	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	ABL1	Homo sapiens	P00519	Anti Tag CoIP	33961781
Intra	ABI2	Q9NYB9	PPIF	Homo sapiens	P30405	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	PRR16	Homo sapiens	Q569H4	Y2H Array	29892012
Intra	ABI2	Q9NYB9	PRR16	Homo sapiens	Q569H4	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	PRR16	Homo sapiens	Q569H4	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	PRR16	Homo sapiens	Q569H4	Y2H Array	25416956
Intra	ABI2	Q9NYB9	WASHC3	Homo sapiens	Q9Y3C0	Y2H Pooling	16189514
Intra	ABI2	Q9NYB9	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	31515488
Intra	ABI2	Q9NYB9	MRPL44	Homo sapiens	Q9H9J2	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	ABI2	Q9NYB9	EFS	Homo sapiens	O43281	Y2H Array	31515488
Intra	ABI2	Q9NYB9	EFS	Homo sapiens	O43281	Y2H Array	25416956
Intra	ABI2	Q9NYB9	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	ABI2	Q9NYB9	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	ABI2	Q9NYB9	HGS	Homo sapiens	O14964	Y2H Array	25416956
Intra	ABI2	Q9NYB9	DTNB	Homo sapiens	O60941	Y2H Array	31515488
Intra	ABI2	Q9NYB9	KRT20	Homo sapiens	P35900	Y2H Pooling	16189514
Intra	ABI2	Q9NYB9	TRIM32	Homo sapiens	Q13049	Y2H Array	31515488
Intra	ABI2	Q9NYB9	TRIM32	Homo sapiens	Q13049	Anti Tag CoIP	33961781
Intra	ABI2	Q9NYB9	TRIM32	Homo sapiens	Q13049	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	TRIM32	Homo sapiens	Q13049	Y2H Array	25416956
Intra	ABI2	Q9NYB9	ARMC7	Homo sapiens	Q9H6L4	Y2H Array	25416956
Intra	ABI2	Q9NYB9	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	X-Ray Diffraction	21107423
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	Anti Tag CoIP	33961781
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	GMS	24439376
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	GMS	19363480
Intra	ABI2	Q9NYB9	NCKAP1	Homo sapiens	Q9Y2A7	GMS	19363480
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	GMS	21107423
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	ITC	24439376
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	Solution Sedimentation	19363480
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	X-Ray Diffraction	24439376
Intra	ABI2	Q9NYB9	NCKAP1	Homo sapiens	Q9Y2A7	Solution Sedimentation	19363480
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	Ion Exchange Chrom	21107423
Intra	ABI2	Q9NYB9	NCKAP1	Homo sapiens	Q9Y2A7	Ion Exchange Chrom	21107423
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	TEM	21107423
Intra	ABI2	Q9NYB9	WASF1	Homo sapiens	Q92558	FPS	24439376
Intra	ABI2	Q9NYB9	IFT20	Homo sapiens	Q8IY31	Y2H Pooling	16189514
Intra	ABI2	Q9NYB9	GCC1	Homo sapiens	Q96CN9	Y2H Array	25416956
Intra	ABI2	Q9NYB9	CRX	Homo sapiens	O43186	Y2H Array	25416956
Intra	ABI2	Q9NYB9	VASP	Homo sapiens	P50552	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	VASP	Homo sapiens	P50552	Y2H Array	25416956
Intra	ABI2	Q9NYB9	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	ABI2	Q9NYB9	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	25416956
Intra	ABI2	Q9NYB9	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25416956
Intra	ABI2	Q9NYB9	IHO1	Homo sapiens	Q8IYA8	Y2H Array	25416956
Intra	ABI2	Q9NYB9	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	ABI2	Q9NYB9	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	ABI2	Q9NYB9	CCHCR1	Homo sapiens	Q8TD31	Y2H Array	29892012

Cross: Cross-species interaction Intra: Intraspecies interaction

ABI2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83095	ABI2 Antibody (YA2840)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h	Lgmd2h Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency Muscular Dystrophy Hutterite Type Sarcotubular Myopathy Limb-Girdle Muscular Dystrophy Type 2h
Cataract 3, Multiple Types	Cataract 3 Multiple Types CTRCT3 Cca2 Cataract, Congenital, Cerulean Type, 2 Cataract 3, Multiple Types, With Or Without Microcornea Cataract 3 Multiple Types With Or Without Microcornea Congenital Cerulean Type Cataract 2 Congenital Cataract Blue Dot Type 2 Congenital Cataract Cerulean Type 2 Cspc Sutural Cataract With Punctate And Cerulean Opacities
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00099	ABI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ABI2	VGNC	VGNC:59487
Macaca mulatta	ABI2	VGNC	VGNC:69518
Canis familiaris	ABI2	VGNC	VGNC:37475
Bos taurus	ABI2	VGNC	VGNC:25506
Rattus norvegicus	ABI2	RGD	RGD:628771
Mus musculus	ABI2	MGD	MGI:106913
Others	ABI2	NCBI