CCHCR1 - coiled-coil alpha-helical rod protein 1 Gene

Homo sapiens

Also known as HCR; SBP; pg8; C6orf18

Gene ID: 54535 | Gene type: protein coding

About CCHCR1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,142,439-31,158,197 (from NCBI)

This gene has 32 transcripts (splice variants), 1 gene allele, 152 orthologues and 2 paralogues. Broad expression in testis (RPKM 37.2), prostate (RPKM 4.5) and 18 other tissues.

Summary

This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]

CCHCR1 Products(11)

mRNA	Protein	Name
NM_001105563.3	NP_001099033.1	coiled-coil alpha-helical rod protein 1 isoform 2
NM_001105564.2	NP_001099034.1	coiled-coil alpha-helical rod protein 1 isoform 1
NM_001394641.1	NP_001381570.1	coiled-coil alpha-helical rod protein 1 isoform 4
NM_001394642.1	NP_001381571.1	coiled-coil alpha-helical rod protein 1 isoform 3
NM_001394643.1	NP_001381572.1	coiled-coil alpha-helical rod protein 1 isoform 3
NM_001394644.1	NP_001381573.1	coiled-coil alpha-helical rod protein 1 isoform 3
NM_001394646.1	NP_001381575.1	coiled-coil alpha-helical rod protein 1 isoform 5
NM_001394647.1	NP_001381576.1	coiled-coil alpha-helical rod protein 1 isoform 6
NM_001394648.1	NP_001381577.1	coiled-coil alpha-helical rod protein 1 isoform 7
NM_001394649.1	NP_001381578.1	coiled-coil alpha-helical rod protein 1 isoform 8
NM_019052.4	NP_061925.2	coiled-coil alpha-helical rod protein 1 isoform 3

CCHCR1 Protein Structure

HCR

0
200
400
600
782 a.a.

Protein Preferred Names

Protein Names

coiled-coil alpha-helical rod protein 1

HCR (a-helix coiled-coil rod homologue)

Related Diseases

Diseases

Alias

Psoriasis

Psoriasis 7

PSORS7	Psoriasis 7, Susceptibility To
Psoriasis Susceptibility 7	Psoriasis
Psoriasis Vulgaris	Pv

Psoriasis 4

PSORS4	Psoriasis Susceptibility 4
Psoriasis 4, Susceptibility To

Psoriasis 9

PSORS9	Psoriasis 9, Susceptibility To
Psoriasis Susceptibility 9

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Keratosis, Seborrheic

Seborrheic Keratosis	Keratosis, Seborrheic, Somatic
Basal Cell Papilloma	Keratosis Seborrheica
KERSEB

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02071	CCHCR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCHCR1	MGD	MGI:2385321
Macaca mulatta	CCHCR1	VGNC	VGNC:81052
Rattus norvegicus	CCHCR1	RGD	RGD:1302992
Bos taurus	CCHCR1	VGNC	VGNC:26938
Felis catus	CCHCR1	VGNC	VGNC:60533
Canis familiaris	CCHCR1	VGNC	VGNC:38877

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