CCHCR1 - coiled-coil alpha-helical rod protein 1 Gene

Also Known as HCR; SBP; pg8; C6orf18

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 54535

About CCHCR1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,142,439-31,158,197 (from NCBI)

This gene has 32 transcripts (splice variants), 1 gene allele, 152 orthologues and 2 paralogues. Broad expression in testis (RPKM 37.2), prostate (RPKM 4.5) and 18 other tissues.

Summary

This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]

CCHCR1 Products (11)

mRNA	Protein	Name
NM_001105563.3	NP_001099033.1	coiled-coil alpha-helical rod protein 1 isoform 2
NM_001105564.2	NP_001099034.1	coiled-coil alpha-helical rod protein 1 isoform 1
NM_001394641.1	NP_001381570.1	coiled-coil alpha-helical rod protein 1 isoform 4
NM_001394642.1	NP_001381571.1	coiled-coil alpha-helical rod protein 1 isoform 3
NM_001394643.1	NP_001381572.1	coiled-coil alpha-helical rod protein 1 isoform 3
NM_001394644.1	NP_001381573.1	coiled-coil alpha-helical rod protein 1 isoform 3
NM_001394646.1	NP_001381575.1	coiled-coil alpha-helical rod protein 1 isoform 5
NM_001394647.1	NP_001381576.1	coiled-coil alpha-helical rod protein 1 isoform 6
NM_001394648.1	NP_001381577.1	coiled-coil alpha-helical rod protein 1 isoform 7
NM_001394649.1	NP_001381578.1	coiled-coil alpha-helical rod protein 1 isoform 8
NM_019052.4	NP_061925.2	coiled-coil alpha-helical rod protein 1 isoform 3

CCHCR1 Protein Structure

HCR

0
200
400
600
782 a.a.

Protein Preferred Names	Protein Names
coiled-coil alpha-helical rod protein 1	HCR (a-helix coiled-coil rod homologue)

CCHCR1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CCHCR1	Q8TD31	IQCC	Homo sapiens	Q4KMZ1	Anti Tag CoIP	33961781
Intra	CCHCR1	Q8TD31	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Psoriasis
Psoriasis 7	PSORS7 Psoriasis 7, Susceptibility To Psoriasis Susceptibility 7 Psoriasis Psoriasis Vulgaris Pv
Psoriasis 4	PSORS4 Psoriasis Susceptibility 4 Psoriasis 4, Susceptibility To
Psoriasis 9	PSORS9 Psoriasis 9, Susceptibility To Psoriasis Susceptibility 9
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Keratosis, Seborrheic	Seborrheic Keratosis Keratosis, Seborrheic, Somatic Basal Cell Papilloma Keratosis Seborrheica KERSEB

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS02071	CCHCR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	CCHCR1	MGD	MGI:2385321
Macaca mulatta	CCHCR1	VGNC	VGNC:81052
Rattus norvegicus	CCHCR1	RGD	RGD:1302992
Bos taurus	CCHCR1	VGNC	VGNC:26938
Felis catus	CCHCR1	VGNC	VGNC:60533
Canis familiaris	CCHCR1	VGNC	VGNC:38877
Others	CCHCR1	NCBI