PRR16 - proline rich 16 Gene

Also Known as DSC54; LARGEN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51334

About PRR16

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:120,464,278-120,794,594 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 1.3), urinary bladder (RPKM 0.9) and 21 other tissues.

Summary

Involved in positive regulation of cell size and positive regulation of translation. [provided by Alliance of Genome Resources, Apr 2022]

PRR16 Products (4)

mRNA Protein Name
NM_001300783.2 NP_001287712.1 protein Largen isoform 1
NM_001308087.1 NP_001295016.1 protein Largen isoform 3
NM_001308088.1 NP_001295017.1 protein Largen isoform 3
NM_016644.2 NP_057728.1 protein Largen isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell size IDA
IDA: Inferred from direct assay
24656129 GOA
involved in positive regulation of translation IDA
IDA: Inferred from direct assay
24656129 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR16 Protein Structure

DUF4589

DUF4589: Domain of unknown function (DUF4589) (53 - 304)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

protein Largen

  • mesenchymal stem cell protein DSC54

PRR16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRR16 Q569H4 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
PRR16 Q569H4 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
PRR16 Q569H4 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bestiality

  • Zoophilia
Penile Cancer

  • Penis Carcinoma

  • Carcinoma Of Penis

  • Penile Neoplasm

  • Penile Carcinoma

  • Penile Neoplasms

  • Malignant Neoplasm Of Penis

  • Ca Penis

  • Malignant Neoplasm Of Body Of Penis

  • Malignant Penile Tumor

  • Penile Ca
Balanoposthitis

  • Balanitis Due To Infection
Methemoglobinemia And Ambiguous Genitalia

  • METAG

  • Methemoglobinemia Type Iv

  • Isolated 17,20-Lyase Deficiency, Pure

  • Methemoglobinemia Due To Deficiency Of Cytochrome B5

  • Methemoglobinemia Type 4

  • Methemoglobinemia Type Iv, Formerly

  • Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

  • Pure Isolated 17,20-Lyase Deficiency

  • Methemoglobinemia, Type Iv
Phimosis

  • Tight Foreskin

  • Tight Frenulum

  • Congenital Phimosis
Cardiomyopathy, Dilated, 1a

  • Dilated Cardiomyopathy 1a

  • Cdcd1

  • CMD1A

  • Cardiomyopathy, Familial Idiopathic

  • Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation

  • Cardiomyopathy, Dilated, With Conduction Defect 1

  • Cardiomyopathy, Idiopathic Dilated

  • Cardiomyopathy, Congestive

  • Dilated Cardiomyopathy With Conduction Defect 1

  • Cardiomyopathy Dilated With Conduction Defect Type 1

  • Cardiomyopathy, Dilated 1a

  • Cardiomyopathy Dilated With Conduction Defect 1

  • Cardiomyopathy, Dilated, Type 1a
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11226 PRR16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PRR16 VGNC VGNC:84482
Bos taurus PRR16 VGNC VGNC:106877
Mus musculus PRR16 MGD MGI:1918623
Felis catus PRR16 VGNC VGNC:102295
Rattus norvegicus PRR16 RGD RGD:1564528
Canis familiaris PRR16 VGNC VGNC:45041
Others PRR16 NCBI